“…It can include the ubiquitous TFs (such as CCAAT/enhancer binding protein (C/EBP) [51] and cyclic AMP response element-binding protein (CREB) [52]), the hepatic enriched master TFs (such as the hepatic nuclear factor 3 (HNF3)/FoxA [53] and HNF4 [54]), and some orphan receptors or coactivator (such as farnesoid X receptor (FXR) [55], retinoid X receptor (RXR) [56], peroxisome proliferator-activated receptor (PPAR) a [56,57], and peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) [58]). Most of the above TFs, such as the HNF4a, FXR, RXR, and PPARa, play key roles in maintaining the homeostasis in hepatic metabolism of glucose, lipids, bile acid, and xenobiotics.…”