2007
DOI: 10.1126/science.1139253
|View full text |Cite
|
Sign up to set email alerts
|

Requirement of bic/microRNA-155 for Normal Immune Function

Abstract: MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

52
1,756
8
25

Year Published

2007
2007
2020
2020

Publication Types

Select...
4
4

Relationship

0
8

Authors

Journals

citations
Cited by 1,734 publications
(1,852 citation statements)
references
References 27 publications
52
1,756
8
25
Order By: Relevance
“…We observed perinuclear miR‐155 staining in pericardial inflammatory patches and infiltrating cells, whereas we did not detect any signal in adjacent cardiomyocytes (Figure 2H). These findings are in line with previous studies showing miR‐155 upregulation in leukocytes following activation 16, 18, 23.…”
Section: Resultssupporting
confidence: 93%
See 2 more Smart Citations
“…We observed perinuclear miR‐155 staining in pericardial inflammatory patches and infiltrating cells, whereas we did not detect any signal in adjacent cardiomyocytes (Figure 2H). These findings are in line with previous studies showing miR‐155 upregulation in leukocytes following activation 16, 18, 23.…”
Section: Resultssupporting
confidence: 93%
“…Macrophage activation and dendritic cell maturation require its upregulation 16, 25, 28. Furthermore, miR‐155 functions at the interface of innate and adaptive immunity as miR‐155 deficient dendritic cells are unable to mount appropriate B and T cell responses 14, 16, 23.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Although the investigation of hypoxic MIRs has been restricted to screenings in cell cultures and in silico comparison with tumor data sets [4], the list of MIRs present in the hypoxic lung has not been compiled thus far. Nevertheless, the first evidence that MIRs may participate in lung diseases was provided by the report that MIR-155 might regulate inflammatory cell responses, such as in asthma [7].…”
Section: Hypoxia Signaling In the Lungmentioning
confidence: 99%
“…Initially, miR-155 was characterized as an oncogenic miRNA and was shown to be dysregulated in a large number of human neoplastic diseases (16). Subsequently, miR-155 was shown to be involved in the modulation of hematopoiesis, and very recently, its importance in the normal function of the immune system has been demonstrated (17)(18)(19).…”
mentioning
confidence: 99%