“…Total omission of Tav resulted in a total block of CaMV replication (Fig. 2C and D, lanes 13), supporting our previous finding that Tav is essential for one or more steps of the CaMV replication cycle (19). TavD1, -D2, -D3, -D4, -D11, and -D12 supported CaMV DNA replication, although to dif- ferent levels: TavD4, nearly 100% of wild type; TavD2 and -D3, 50 to 70%; TavD12, 20%; TavD11, 5%; TavD1, 1% (Fig.…”