2020
DOI: 10.21203/rs.3.rs-34401/v1
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Required concentration index quantifies effective drug combinations against hepatitis C virus infection

Abstract: Successful clinical drug development requires rational design of combination treatments based on preclinical data. Anti-HCV drugs exhibit significant diversity in antiviral effect. Dose-response assessments can be used to determine parameters profiling the diverse antiviral effect during combination treatment. In the current study, a combined experimental and mathematical approaches were used to compare and score different combinations of anti-hepatitis C virus (HCV) treatments. A “required concentration index… Show more

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