Repurposing Sitafloxacin, Prulifloxacin, Tosufloxacin, and Sisomicin as Antimicrobials Against Biofilm and Persister Cells of Pseudomonas aeruginosa

She, Pengfei; Li, Shijia; Liu, Yaqian; Xu, Lei; Zhou, Linying; Zeng, Xianghai; Li, Yimin; Li, Shasha; Li, Zehao; Hussain, Zubiar; Wu, Yong

doi:10.1007/s00284-021-02729-w

Cited by 1 publication

(1 citation statement)

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“…Infectious diseases caused by pathogenic microorganisms have now become one of the main causes of morbidity globally. One major reason is that pathogenic microorganisms can easily spread through daily behaviors and social interactions, including having dinner, unpacking mail, shaking hands, and hugging, as they can adhere to or colonize the surface of household items’ materials like glass, wood, plastic, and metal, as well as our body, such as skin and oral mucosa, and transmit by surface contact, posing serious challenges to personal hygiene and healthcare [ 1 , 2 ]. The use of disinfectants has been considered an efficient approach to control the transmission of pathogenic microorganisms through the surface contact pathway [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Combination of Cetylpyridinium Chloride and Chlorhexidine Acetate: A Promising Candidate for Rapid Killing of Gram-Positive/Gram-Negative Bacteria and Fungi

Zhu

Zhang

et al. 2023

Curr Microbiol

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Combined use of the present antimicrobial drugs has been proved to be an alternative approach for antimicrobial agents’ development since the co-existed of the drugs working in different mechanism have been demonstrated potentially enhance their antimicrobial activity. In this work, antibacterial and antifungal activity of the cetylpyridinium chloride (CPC)/chlorhexidine acetate (CHA) combination was evaluated for the first time, while a universal concentration for the rapid killing of gram-positive/gram-negative bacteria and fungi was also proposed. The minimum inhibitory concentrations (MIC) of CPC and CHA used alone or in combination were first measured, showing that the combined treatment decreased the MIC against tested gram-positive/gram-negative bacteria and fungi to 1/8–1/2. Growth curve assays demonstrated CPC and CHA had dynamic combined effects against the tested microorganisms at the concentration equal to MIC. Besides, combined use of these two drugs could also enhance their biocidal activity, which was illustrated by fluorescence microscopy and SEM images, as well as soluble protein measurement. More importantly, in vitro acute eye and skin irritation tests showed short-term contact with CPC/CHA combination would not cause any damage to mammalian mucosa and skin. In a word, CPC/CHA combination exhibited broad-spectrum antibacterial and antifungal activity against tested gram-positive/gram-negative bacteria and fungi while without any acute irritation to mammalian mucosa and skin, providing a new perspective on the selection of personal disinfectants. Supplementary Information The online version contains supplementary material available at 10.1007/s00284-023-03198-z.

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Section: Introductionmentioning

confidence: 99%