2020
DOI: 10.37871/jbres1153
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Repurposing Potential of Diminazene Aceturate as an Inhibitor of the E. coli DNA Gyrase B

Abstract: Drug-resistant Escherichia coli (E. coli) has overburdened the healthcare facilities in recent years and is getting hard to combat, mandating search for novel therapeutics with a broad antibacterial spectrum and high chemotherapeutic index. The 24 kDa domain of DNA gyrase B that is involved in the ATPase activity has been reported to be a promising target for inhibitors. A PDB structure (1KZN) of the 24kD domain of gyrase B with the co-crystallized ligand clorobiocin was used for the docking studies to explore… Show more

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“…Numerous studies have found that flavonoids exert their antibacterial activities through a variety of different mechanism of action [31], one of which is through the inhibition of ATPase DNA gyrase B [30]. The 24 kDa ATPase domain of DNA gyrase B has been reported to be a potential target protein for antibiotic development [32]. Therefore, in this research, we try to screen flavonoids from genus Erythrina for their potency as inhibitors of ATPase DNA gyrase B through an in silico study.…”
Section: Discussionmentioning
confidence: 99%
“…Numerous studies have found that flavonoids exert their antibacterial activities through a variety of different mechanism of action [31], one of which is through the inhibition of ATPase DNA gyrase B [30]. The 24 kDa ATPase domain of DNA gyrase B has been reported to be a potential target protein for antibiotic development [32]. Therefore, in this research, we try to screen flavonoids from genus Erythrina for their potency as inhibitors of ATPase DNA gyrase B through an in silico study.…”
Section: Discussionmentioning
confidence: 99%