Repurposing of existing antibiotics for the treatment of diabetes mellitus

Alam, Muhammad Shaiful; Uddin, Md. Sohorab; Shamsuddin, Tahmida; Rubayed, Maruf; Sharmin, Tania; Akter, Rasheda

doi:10.1007/s40203-021-00118-6

Cited by 1 publication

(2 citation statements)

References 53 publications

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“…By raising insulin secretion and lowering glucagon secretion, GLP-1 reduces blood glucose levels. Recent in silico study demonstrated that CLIN has competitive inhibitory action on DPP-4 thus conferring antidiabetic activity …”

Section: Resultsmentioning

confidence: 98%

“…Recent in silico study demonstrated that CLIN has competitive inhibitory action on DPP-4 thus conferring antidiabetic activity. 70 Further observation revealed that the diabetic mice's blood glucose levels dropped further after being treated with CLIN@ CNP loaded nanofibers (S3) compared to that consisting of just CLIN (S2). This could be as a result of the synergized antidiabetic impact of CNPs and AVE. Few research studies claim that blood insulin levels are significantly raised by nanoceria, which play a unique and efficient role in decreasing glucose levels.…”

Section: 3mentioning

confidence: 99%

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Electrospun Cerium Oxide Nanoparticle/Aloe Vera Extract-Loaded Nanofibrous Poly(Ethylene Oxide)/Polyurethane Mats As Diabetic Wound Dressings

Ghosh,

Saha,

Bhattacharya

et al. 2024

ACS Appl. Bio Mater.

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Currently the prevalence of diabetic wounds brings a huge encumbrance onto patients, causing high disability and mortality rates and a major medical challenge for society. Therefore, in this study, we are targeting to fabricate aloe vera extract infused biocompatible nanofibrous patches to facilitate the process of diabetic wound healing. Additionally, clindamycin has been adsorbed onto the surface of in-house synthesized ceria nanoparticles and again used separately to design a nanofibrous web, as nanoceria can act as a good drug delivery vehicle and exhibit both antimicrobial and antidiabetic properties. Various physicochemical characteristics such as morphology, porosity, and chemical composition of the produced nanofibrous webs were investigated. Bacterial growth inhibition and antibiofilm studies of the nanofibrous materials confirm its antibacterial and antibiofilm efficacy against Gram-positive and Gram-negative bacteria. An in vitro drug release study confirmed that the nanofibrous mat show a sustained drug release pattern (90% of drug in 96 h). The nanofibrous web containing drug loaded nanoceria not only showed superior in vitro performance but also promoted greater wound contraction (95 ± 2%) in diabetes-induced mice in just 7 days. Consequently, it efficaciously lowers the serum glucose level, inflammatory cytokines, oxidative stress, and hepatotoxicity markers as endorsed by various ex vivo tests. Conclusively, this in-house-fabricated biocompatible nanofibrous patch can act as a potential medicated suppository that can be used for treating diabetic wounds in the proximate future.

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Section: Resultsmentioning

confidence: 98%

Section: 3mentioning

confidence: 99%