Repurposing of Antifungal Drug Flucytosine/Flucytosine Cocrystals for Anticancer Activity against Prostate Cancer Targeting Apoptosis and Inflammatory Signaling Pathways
Manimurugan Kanagavel,
Rajan Marystella Sparjan Samuvel,
Vaikundamoorthy Ramalingam
et al.
Abstract:This study aimed to repurpose the antifungal drug flucytosine (FCN) for anticancer activity together with cocrystals of nutraceutical coformers sinapic acid (SNP) and syringic acid (SYA). The cocrystal screening experiments with SNP resulted in three cocrystal hydrate forms in which two are polymorphs, namely, FCN-SNP F−I and FCN-SNP F−II, and the third one with different stoichiometry in the asymmetric unit (1:2:1 ratio of FCN:SNP:H 2 O, FCN-SNP F−III). Cocrystallization with SYA resulted in two hydrated cocr… Show more
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