Repurposing EGFR Inhibitors for Oral Cancer Pain and Opioid Tolerance
Maria Daniela Santi,
Morgan Zhang,
Naijiang Liu
et al.
Abstract:Oral cancer pain remains a significant public health concern. Despite the development of improved treatments, pain continues to be a debilitating clinical feature of the disease, leading to reduced oral mobility and diminished quality of life. Opioids are the gold standard treatment for moderate-to-severe oral cancer pain; however, chronic opioid administration leads to hyperalgesia, tolerance, and dependence. The aim of this review is to present accumulating evidence that epidermal growth factor receptor (EGF… Show more
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