Repurposing artemisinin as an anti-mycobacterial agent in synergy with rifampicin

Patel, Yesha; Mistry, Nishita; Mehra, Sarika

doi:10.1016/j.tube.2019.03.004

Cited by 23 publications

(16 citation statements)

References 37 publications

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“…One interesting case was with artemisinin, one class of drug found in the screening, that was shown to target the heme of DevS and DosT [108]. Other laboratories had shown the potential anti-tuberculosis activity of this old compound also in combination with isoniazid (and other anti-TB drugs) [110,111], but there was no clue about its potential target. These exciting studies may continue and eventually provide a leading compound targeting dormant bacteria, a major issue during tuberculosis treatment.…”

Section: Pharmacological Usementioning

confidence: 99%

Heme-Based Gas Sensors in Nature and Their Chemical and Biotechnological Applications

Gondim

Guimarães

Sousa

2022

BioChem

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Sensing is an essential feature of life, where many systems have been developed. Diatomic molecules such as O2, NO and CO exhibit an important role in life, which requires specialized sensors. Among the sensors discovered, heme-based gas sensors compose the largest group with at least eight different families. This large variety of proteins also exhibits many distinct ways of sensing diatomic molecules and promote a response for biological adaptation. Here, we briefly describe a story of two impressive systems of heme-based oxygen sensors, FixL from Rhizobium and DevS(DosS)/DosT from Mycobacterium tuberculosis. Beyond this, we also examined many applications that have emerged. These heme-based gas sensors have been manipulated to function as chemical and biochemical analytical systems to detect small molecules (O2, CO, NO, CN−), fluorophores for imaging and bioanalysis, regulation of processes in synthetic biology and preparation of biocatalysts among others. These exciting features show the robustness of this field and multiple opportunities ahead besides the advances in the fundamental understanding of their molecular functioning.

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Section: Pharmacological Usementioning

confidence: 99%

Heme-Based Gas Sensors in Nature and Their Chemical and Biotechnological Applications

Gondim

Guimarães

Sousa

2022

BioChem

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“…It contains artemisinin as a biologically active compound, which, along with its semi-synthetic derivative, artesunate, was recently described as having potential anti-TB activity [103]. Further, artemisinin showed synergistic activity with rifampicin against M. bovis BCG and M. tuberculosis H37Ra, and peroxide production increased in cells treated with both drugs [104]. Persea americana seeds are usually used in traditional Mexican medicine to treat several chronic, infectious diseases, and dysentery caused by helminths and amoebas.…”

Section: Plants As a Source Of Natural Products Used In Traditional Medicinementioning

confidence: 99%

Overcoming the Prokaryote/Eukaryote Barrier in Tuberculosis Treatment: A Prospect for the Repurposing and Use of Antiparasitic Drugs

2021

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Antimicrobial resistance, the so-called silent pandemic, is pushing industry and academia to find novel antimicrobial agents with new mechanisms of action in order to be active against susceptible and drug-resistant microorganisms. In the case of tuberculosis, the need of novel anti-tuberculosis drugs is specially challenging because of the intricate biology of its causative agent, Mycobacterium tuberculosis. The repurposing of medicines has arisen in recent years as a fast, low-cost, and efficient strategy to identify novel biomedical applications for already approved drugs. This review is focused on anti-parasitic drugs that have additionally demonstrated certain levels of anti-tuberculosis activity; along with this, natural products with a dual activity against parasites and against M. tuberculosis are discussed. A few clinical trials have tested antiparasitic drugs in tuberculosis patients, and have revealed effective dose and toxicity issues, which is consistent with the natural differences between tuberculosis and parasitic infections. However, through medicinal chemistry approaches, derivatives of drugs with anti-parasitic activity have become successful drugs for use in tuberculosis therapy. In summary, even when the repurposing of anti-parasitic drugs for tuberculosis treatment does not seem to be an easy job, it deserves attention as a potential contributor to fuel the anti-tuberculosis drug pipeline.

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“…ART has been reported to exhibit antileishmanial activity in particular against visceral leishmaniasis [14]. New reports indicate that this drug can be used as an anti-mycobacterial [15]. Despite ART's potential uses and decades of research, knowledge gaps concerning its mechanism and its specific targets remain glaring.…”

Section: Introductionmentioning

confidence: 99%

Artemisinin DNA Base Interaction Studies in Presence of Fe(II): LC/TOF MS Separation of Reaction Products

Oke

2021

Separations

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Artemisinin (ART) is a sesquiterpene lactone and a popular malaria drug with potential anticancer properties. In this work, LC/TOF/MS, was used to investigate the reaction of ART with DNA bases. ART-deoxyadenosine and ART-deoxycytidine interactions, were studied in the presence of iron II ions. ART-deoxyadenosine and ART-deoxycytidine reaction mixtures gave chromatographic signatures that remained fairly unchanged at room temperature but grew after incubation at 37 °C. The change in temperature from room temperature to 37 °C was the main driver of adduct formation in these reactions. ART was found to react with Fe(II) ions as observed from several new chromatographic peaks. ART-deoxyadenosine as well as ART-deoxycytidine in the presence of Fe(II) ions resulted in formation of new chromatographic signatures of adducts consisting of DNA bases and ART. It was clear that addition of iron (II) to DNA base-ART mixtures gave rise to new reaction products mediated by a different reaction mechanism. Studies of ART reactions with DNA in vitro is key in elucidating elusive mechanism of this drug.

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Repurposing artemisinin as an anti-mycobacterial agent in synergy with rifampicin

Cited by 23 publications

References 37 publications

Heme-Based Gas Sensors in Nature and Their Chemical and Biotechnological Applications

Heme-Based Gas Sensors in Nature and Their Chemical and Biotechnological Applications

Overcoming the Prokaryote/Eukaryote Barrier in Tuberculosis Treatment: A Prospect for the Repurposing and Use of Antiparasitic Drugs

Artemisinin DNA Base Interaction Studies in Presence of Fe(II): LC/TOF MS Separation of Reaction Products

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