Reprotoxic activities of vildagliptin administration in male Wistar rats

Stephen, Akinsomisoye Olumide; Rotimi, O; Adegoke, Azeez Taoreed; Samson, Osuntokun Opeyemi

doi:10.1590/s2175-97902020000119144

Cited by 1 publication

(2 citation statements)

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“…Isdadiyanto and Tana (2020) revealed that the number of normal Leydig cells in male Wistar rats at 8-12 weeks of age was reported to be 14.70±2.65 cells. [16] The average testosterone level in a study conducted by Stephen et al (2021) in male Wistar rats at three months of age was 10.03±1.28 ng/ml, while in this study, the serum testosterone level in control rats with excessive exercise was 4.94±0.21 ng/ml. [17] This shows that excessive exercise for 40 days reduces Leydig cell number and serum testosterone in male Wistar rats.…”

Section: Discussioncontrasting

confidence: 49%

“…[16] The average testosterone level in a study conducted by Stephen et al (2021) in male Wistar rats at three months of age was 10.03±1.28 ng/ml, while in this study, the serum testosterone level in control rats with excessive exercise was 4.94±0.21 ng/ml. [17] This shows that excessive exercise for 40 days reduces Leydig cell number and serum testosterone in male Wistar rats. Physical exercise increases carbon dioxide production, causing lactic acid to accumulate, and decreases hemoglobin oxygen saturation, increasing oxygen demand.…”

Section: Discussioncontrasting

confidence: 49%

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Vitamin E Increases Leydig Cells and Testosterone in Rats with Excessive Exercise

2023

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Background. Excessive exercise increases oxidative stress, which affects cell damage, including Leydig cells. Damage to Leydig cells leads to a drop in testosterone levels. Vitamin E is known to protect spermatogenesis by inhibiting Leydig cell apoptosis and lipid peroxidation. This study investigates vitamin E efficacy in increasing Leydig cells count and testosterone levels in male Wistar rats exposed to excessive physical exercise. Methods. Thirty-six male Wistar rats were divided into the control and treatment groups in this posttest-only control group experimental study. The control group was a group that received excessive exercise and 1 ml/day of distilled water once daily. The treatment group was a group that received excessive exercise and vitamin E (20 mg/day) dissolved in distilled water up to 1 ml once daily. Excessive exercise in this study was swimming ≥ 60 minutes a day in an 80 cm x 50 cm pool with 60 cm deep. After 40 days; Leydig cells number and testosterone levels were examined and compared between groups. Results. Leydig cells' mean value in the treatment group was 2.6 times higher than the control (10.23±0.73 vs. 3.83±0.67; p<0.001). For testosterone levels, the mean value was 2.3 times higher in the treatment group compared to control (11.42±0.27 ng/mL vs. 4.94±0.21 ng/mL; p<0.001). Conclusions. Oral administration of vitamin E (20 mg/day) for 40 days increased Leydig cell number and testosterone levels in Wistar rats with excessive physical exercise compared to controls. Vitamin E might be considered a treatment for male Keywords: antioxidant; exercise; testosterone; vitamin E

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Section: Discussioncontrasting

confidence: 49%