Reprogramming Metabolic Flux in Escherichia Coli to Enhance Chondroitin Production
Chunlei Zhao,
Xiaomin Li,
Liang Guo
et al.
Abstract:Reprogramming metabolic flux is a promising approach for constructing efficient microbial cell factories (MCFs) to produce chemicals. However, how to boost the transmission efficiency of metabolic flux is still challenging in complex metabolic pathways. In this study, metabolic flux is systematically reprogrammed by regulating flux size, flux direction, and flux rate to build an efficient MCF for chondroitin production. The ammoniation pool for UDP‐GalNAc synthesis and the carbonization pool for UDP‐GlcA synth… Show more
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