Reprogramming inflammatory macrophages with mesenchymal stromal cells

Min, Hyun Jin; Xu, Li; Parrott, Roberta E.; Rabjohns, Emily M.; Rampersad, Rishi R.; Tarrant, Teresa K.; Overall, Christopher C.; Lillich, M.; Meadows, N.; Kurtzberg, J.; Filiano, Anthony J.

doi:10.1016/j.jcyt.2020.03.138

Cited by 2 publications

(1 citation statement)

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“…Min et al proposed a mechanism whereby macrophages express LRP markers and internalize cytoplasmic components of apoptotic MSCs. Subsequently, these macrophages downregulate genes related to antigen presentation, resulting in the suppression of T-cell activation and reducing inflammation (119). Similarly, Piraghaj et al demonstrated that macrophages tended to polarize towards the M2 phenotype, leading to decreased production of TNF-a and NO, increased production of IL-10, and enhanced phagocytic activity in response to coincubation with apoptotic MSCs (120).…”

Section: Phagocytosis and Internalizationmentioning

confidence: 99%

Plasticity and crosstalk of mesenchymal stem cells and macrophages in immunomodulation in sepsis

Tao,

Wang,

Liu

et al. 2024

Front. Immunol.

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Sepsis is a multisystem disease characterized by dysregulation of the host immune response to infection. Immune response kinetics play a crucial role in the pathogenesis and progression of sepsis. Macrophages, which are known for their heterogeneity and plasticity, actively participate in the immune response during sepsis. These cells are influenced by the ever-changing immune microenvironment and exhibit two-sided immune regulation. Recently, the immunomodulatory function of mesenchymal stem cells (MSCs) in sepsis has garnered significant attention. The immune microenvironment can profoundly impact MSCs, prompting them to exhibit dual immunomodulatory functions akin to a double-edged sword. This discovery holds great importance for understanding sepsis progression and devising effective treatment strategies. Importantly, there is a close interrelationship between macrophages and MSCs, characterized by the fact that during sepsis, these two cell types interact and cooperate to regulate inflammatory processes. This review summarizes the plasticity of macrophages and MSCs within the immune microenvironment during sepsis, as well as the intricate crosstalk between them. This remains an important concern for the future use of these cells for immunomodulatory treatments in the clinic.

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Section: Phagocytosis and Internalizationmentioning

confidence: 99%

Plasticity and crosstalk of mesenchymal stem cells and macrophages in immunomodulation in sepsis

Tao,

Wang,

Liu

et al. 2024

Front. Immunol.

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Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases

et al. 2021

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Mesenchymal stromal cells (MSCs) are a mesodermal stem cell population, with known self-renewal and multilineage differentiation properties. In the last century, MSCs have been widely used in regenerative medicine and tissue engineering approaches. MSCs initially were isolated from bone marrow aspirates, but currently have been identified in a great number of tissues of the human body. Besides their utilization in regenerative medicine, MSCs possess significant immunoregulatory/immunosuppressive properties, through interaction with the cells of innate and adaptive immunity. MSCs can exert their immunomodulatory properties with either cell-cell contact or via paracrine secretion of molecules, such as cytokines, growth factors and chemokines. Of particular importance, the MSCs’ immunomodulatory properties are explored as promising therapeutic strategies in immune-related disorders, such as autoimmune diseases, graft versus host disease, cancer. MSCs may also have an additional impact on coronavirus disease-19 (COVID-19), by attenuating the severe symptoms of this disorder. Nowadays, a great number of clinical trials, of MSC-mediated therapies are evaluated for their therapeutic potential. In this review, the current knowledge on cellular and molecular mechanisms involved in MSC-mediated immunomodulation were highlighted. Also, the most important aspects, regarding their potential application in immune-related diseases, will be highlighted. The broad application of MSCs has emerged their role as key immunomodulatory players, therefore their utilization in many disease situations is full of possibilities for future clinical treatment.

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Reprogramming inflammatory macrophages with mesenchymal stromal cells

Cited by 2 publications

References 0 publications

Plasticity and crosstalk of mesenchymal stem cells and macrophages in immunomodulation in sepsis

Plasticity and crosstalk of mesenchymal stem cells and macrophages in immunomodulation in sepsis

Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases

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