Reprogramming Exosomes to Escape from Immune Surveillance for Mitochondrial Protection in Hepatic Ischemia-Reperfusion Injury
Shanshan Liu,
Xinyu Xiao,
La Zhang
et al.
Abstract:Background:
Therapeutic interventions such as synthetic drugs and microRNA (miR) modulators have created opportunities for mitigating hepatic ischemia/reperfusion injury (HIRI) by alleviating mitochondrial dysfunction. However, delivering multi-therapeutic ingredients with low toxicity to hepatocytes still lags behind its development.
Methods:
In this study, we endowed exosomes with delivery function to concentrate on hepatocytes for multidimensionally halting mitochondria dy… Show more
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