Reprogrammable Soft Swimmers for Minimally Invasive Thrombus Extraction

Pozhitkova, Anna V.; Kladko, Daniil V.; Винник, Д.А.; Taskaev, S.V.; Vinogradov, Vladimir V.

doi:10.1021/acsami.2c04745

Cited by 14 publications

(6 citation statements)

References 72 publications

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“…As guided by the roadmap, both responsive particles and polymer matrices play a vital role. ,, The former is special because the magnetization states of particles, including the direction and switching fields, can be encoded in their structure, composition, and spatial distributions. The encoded magnetic properties can be translated into forces and torques in the soft matrix materials, which is similar to programming the ensemble structures, to allow their use in the development of intelligent microrobots.…”

Section: Technological Trend Of Designing and Manufacturing Responsiv...mentioning

confidence: 99%

Responsive Magnetic Nanocomposites for Intelligent Shape-Morphing Microrobots

et al. 2023

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With the development of advanced biomedical theragnosis and bioengineering tools, smart and soft responsive microstructures and nanostructures have emerged. These structures can transform their body shape on demand and convert external power into mechanical actions. Here, we survey the key advances in the design of responsive polymer− particle nanocomposites that led to the development of smart shapemorphing microscale robotic devices. We overview the technological roadmap of the field and highlight the emerging opportunities in programming magnetically responsive nanomaterials in polymeric matrixes, as magnetic materials offer a rich spectrum of properties that can be encoded with various magnetization information. The use of magnetic fields as a tether-free control can easily penetrate biological tissues. With the advances in nanotechnology and manufacturing techniques, microrobotic devices can be realized with the desired magnetic reconfigurability. We emphasize that future fabrication techniques will be the key to bridging the gaps between integrating sophisticated functionalities of nanoscale materials and reducing the complexity and footprints of microscale intelligent robots.

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Section: Technological Trend Of Designing and Manufacturing Responsiv...mentioning

confidence: 99%

Responsive Magnetic Nanocomposites for Intelligent Shape-Morphing Microrobots

et al. 2023

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“…At Daegu Gyeongbuk Institute of Science and Technology, Hwang et al [43] reported that an electromagnetically controllable micro-robot intervention system could help doctors remotely manipulate micro-diameter guidewires in real time and complete cardiovascular interventions in vascular phantoms. At ITMO University, Pozhitkova et al [44] proposed an attractive solution for thrombosis treatment via reprogrammable magnetic soft robots. At the Massachusetts Institute of Technology, Kim et al [45] proposed a teleoperated robotic neuro-interventional platform based on magnetic manipulation.…”

Section: Laboratory Robotsmentioning

confidence: 99%

Performance Evaluation of a Vascular Interventional Surgery Robotic System with Visual-Based Force Feedback

Shi

Ishihara

2023

Machines

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Robot-assisted systems for vascular interventional surgery (VIS) have the advantages of high precision and an improved operating environment for the surgeon. However, the current robot-assisted systems cannot completely replace human beings in controlling interventional devices—for example, rapid guidewire/catheter replacement and force feedback. In the face of these challenges, the robot-assisted system presented in this article can better solve the above problems. The experiments for the guidewire and catheter were designed and performed separately based on the developed robot-assisted system. The experimental results show that the participants can use the system to manipulate the guidewire and catheter to reach the designated blood vessel position. Based on the experiments for the catheter, for the first time, the reciprocating manipulation method with visual-based force feedback (VFF) was used for experimental evaluation. The experimental results show that this method can effectively avoid the buckling phenomenon of the catheter; the VFF plays a vital role in improving the safety of the operation and provides an operational assessment of VIS safety. In addition, this article puts forward the evaluation index for maximum pull force (MPLF) and force fluctuation, which provides an essential reference for enriching the evaluation of VIS technical skills.

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“…44 These materials consist of soft matrices with embedded hard magnetic particles, and the interaction between the magnetic torque and internal mechanical force allows for the remote control of such systems. The mechanical force from such magnetic soft robots has already shown their effectiveness for model thrombosis treatment, 45,46 drug or object delivery, 47,48 and catheter guiding for surgical applications. 35,49 Herein, we demonstrate the use of magnetic soft robots for biofilm eradication in vitro.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Soft Robot for Minimally Invasive Urethral Catheter Biofilm Eradication

Baburova,

Kladko,

Lokteva

et al. 2023

ACS Nano

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Catheter-related biofilm infection remains the main problem for millions of people annually, affecting morbidity, mortality, and quality of life. Despite the recent advances in the prevention of biofilm formation, alternative methods for biofilm prevention or eradication still should be found to avoid traumatic and expensive removal or catheter replacement. Soft magnetic robots have drawn significant interest in favor of remote control, fast response, and wide space for design. In this work, we demonstrated magnetic soft robots as a minimally invasive, safe, and effective approach to eliminate biofilm from urethral catheters (20 Fr or 5.1 mm in diameter). Seven designs of the robot were fabricated (size 4.5 × 15 mm), characterized, and tested in the presence of a rotating magnetic field. As a proof-of-concept, we demonstrated the superior efficiency of biofilm removal on the model of a urethral catheter using a magnetic robot, reaching full eradication for the octagram-shaped robot (velocity 2.88 ± 0.6 mm/s) at a 15 Hz frequency and a 10 mT amplitude. These findings are helpful for the treatment of biofilm-associated catheter contamination, which allows an increase in the catheter wearing time without frequent replacement and treatment of catheter-associated infections.

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Reprogrammable Soft Swimmers for Minimally Invasive Thrombus Extraction

Cited by 14 publications

References 72 publications

Responsive Magnetic Nanocomposites for Intelligent Shape-Morphing Microrobots

Responsive Magnetic Nanocomposites for Intelligent Shape-Morphing Microrobots

Performance Evaluation of a Vascular Interventional Surgery Robotic System with Visual-Based Force Feedback

Magnetic Soft Robot for Minimally Invasive Urethral Catheter Biofilm Eradication

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