Reproductive Tract infections and Premalignant Lesions of Cervix: Evidence from Women Presenting at the Cancer Detection Centre of the Indian Cancer Society, Delhi, 2000–2012

Dey, Subhojit; Pahwa, Parika; Mishra, Arti; Govil, J. N.; Dhillon, Preet K.

doi:10.1007/s13224-015-0819-1

Cited by 11 publications

(18 citation statements)

References 26 publications

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“…While HPV persistence is a strong predictor of HSIL and the development of cervical cancer, LSIL may instead be associated with other clinical conditions. LSIL has been associated with current chlamydia infection , trichomoniasis and bacterial vaginosis . As the number of cases of individual STIs and RTIs was low, we did not attempt to stratify individual RTIs and STIs in the binary logistic regression analysis.…”

Section: Discussionmentioning

confidence: 99%

Persistence rate of cervical human papillomavirus infections and abnormal cytology in Rwanda

et al. 2019

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Objectives In this study, we determined the incidence and persistence of human papillomavirus (HPV) strains and of squamous intraepithelial lesions (SIL) or worse cytology in 237 HIV‐positive and HIV‐negative Rwandan women and whether the interleukin (IL)‐28B single nucleotide polymorphism (SNP) at rs12979860 correlated with susceptibility to and persistence of HPV infection. Methods Cervical samples were collected at baseline and after 9, 18 and 24 months for a 40‐HPV DNA screening test and a ThinPrep Pap test. Genotyping of the IL‐28B SNP rs12979860 was performed using real‐time polymerase chain reaction (PCR). Results Chronic high‐risk (HR) HPV infections occurred in 56% of HIV‐positive women, while no HIV‐negative women developed HPV chronicity. High‐grade SIL (HSIL) or cancer was diagnosed in 38% of HIV‐positive women with persistent HR‐HPV infections. HIV and HR‐HPV positivity at baseline were factors associated with an increased risk of HPV persistence. Additionally, HR‐HPV positivity at baseline was associated with an increased risk of developing HSIL or worse cytology. The unfavourable T/x genotype at rs12979860 is common among Africans, and women with this genotype were found to be more commonly infected with HPV. Conclusions HPV screening in Rwanda may help to identify women at risk of developing cervical cancer and polymorphism in IL‐28B may be associated with risk of contracting HPV infection.

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Section: Discussionmentioning

confidence: 99%

Persistence rate of cervical human papillomavirus infections and abnormal cytology in Rwanda

et al. 2019

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“…A study from India, which included 11,427 women over a period of 2000-2012, reported that 7.9% of women with reproductive tract infection had AS-CUS. In addition, Trichomonas vaginalis infection was significantly associated with abnormal Pap, such as ASCUS and LSIL (P < 0.001) [23].…”

Section: Discussionmentioning

confidence: 96%

The prevalence of abnormal pap smear in women with pelvic inflammatory disease and determine the risk factors of cervical intra-epithelial neoplasia 2/3

2021

European Journal of Gynaecological Oncology

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To investigate the prevalence of abnormal Pap (ASCUS or worse) and HPV infection in women with pelvic in lammatory disease (PID) and assess the risk factors for CIN2/3. Methods: Retrospective chart review of 249 women who were admitted to the hospital for the treatment of PID between 2013 and 2019 was performed. Patients' characteristics including age, parity, sexually transmitted disease (STD) infection, Pap results, human papilloma virus (HPV) infection, Nugent score, C-reactive protein (CRP), and neutrophil to lymphocyte ratio (NLR) were retrieved. Clinical characteristics were compared between group 1 (women with normal pap; N = 159) and group 2 (women with abnormal Pap; N = 90). Results: Of 249 women, abnormal Pap rate was 36.1% and HPV positivity was 41.0%. Of those with HPV infection, 78.4% had high-risk HPV subtypes. Group 2 was significantly associated with high-risk HPV infection (P < 0.0001) and low NLR (P = 0.047). 74 women underwent colposcopy-directed punch biopsy, and 14 showed CIN2/3. Multivariate analysis showed that high-risk HPV infection (P = 0.040; 95% CI 1.081-32.389) and low Nugent score (≤ 3) (P = 0.003; 95% CI 2.130-39.807) were independent risk factors of CIN2/3 in women with abnormal Pap and PID. Conclusions: Women with PID showed high prevalence of abnormal Pap. Nonetheless, high-risk HPV infection and low Nugent score are the most reliable factors in determining colposcopy for the diagnosis of CIN2/3.

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“…Awareness of tribal respondents belonging to older age group outside the purview of this study need to be studied that researcher due to the limitations of this study the researcher couldn't cover. This study can act for advocating the rights of tribal women's health especially when gynecological cancers have been to factors like lack of awareness and hygiene, and limited access to gynaecologists [11]. The sources of awareness covered an important part of the problem that can be used to design intervention to address the issue .…”

Section: Discussionmentioning

confidence: 99%

Awareness about Gynecological Cancers amongst Tribal Females

Jha¹,

Panot

Singh³

2020

Asian Pac J Cancer Care

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Background: Gender differences are engrained in our culture and are evident when perceiving women’s health and ill health. Health issues of women are of great importance in a society as it directly impacts the fabric of family and society. With limited access to education or employment, high illiteracy rates and increasing poverty levels health improvements for women are quite difficult in developing countries including India. There is a significant lack of official data on gynecological cancers further for women from tribal population which is important for advocacy and public health care planning. Aim: Study aimed at assessing awareness of gynecological cancers amongst tribal females in Borivali Taluka of Mumbai, Maharashtra. Methodology: The research is a descriptive study with a cross-sectional research design. 100 tribal female comprised the total sample. Result: Significant lack of awareness about the Gynecological cancers was seen in the tribal respondents of Aarey circle of Borivalli Taluka, Mumbai regarding the symptoms, treatment, and preventive measures of gynecological cancers. Conclusion: It is evident from previous as well as current study several factors are responsible for poor awareness about gynecological cancers among marginalized tribal respondents.

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Reproductive Tract infections and Premalignant Lesions of Cervix: Evidence from Women Presenting at the Cancer Detection Centre of the Indian Cancer Society, Delhi, 2000–2012

Cited by 11 publications

References 26 publications

Persistence rate of cervical human papillomavirus infections and abnormal cytology in Rwanda

Persistence rate of cervical human papillomavirus infections and abnormal cytology in Rwanda

The prevalence of abnormal pap smear in women with pelvic inflammatory disease and determine the risk factors of cervical intra-epithelial neoplasia 2/3

Awareness about Gynecological Cancers amongst Tribal Females

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