Reproductive toxicity of polystyrene nanoplastics in Drosophila melanogaster under multi-generational exposure

Tu, Qinghui; Deng, Jianhao; Di, Miaomiao; Lin, Xiaorong; Chen, Zhongzheng; Li, Bin; Tian, Ling; Zhang, Yuanyuan

doi:10.1016/j.chemosphere.2023.138724

Cited by 15 publications

(2 citation statements)

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“…Currently, most investigations involving multiple generations exposed to various NPs (such as gold, silver, cobalt, polystyrene, silicon dioxide, and quantum dots) have primarily focused on reproductive disorders [ 23 , 24 , 25 , 45 , 46 , 47 , 48 ]. For instance, in a study with D. melanogaster , the insects were exposed to different concentrations (1, 10, 50, and 100 mg∙L −1 ) of polystyrene nanoplastics over five generations.…”

Section: Discussionmentioning

confidence: 99%

“…In the fifth generation, oocytes revealed a significant level of apoptosis and necrosis, which correlated with dose. The study proposed a potential mechanism for reproductive toxicity [ 45 ]. On the other hand, Heinlaan et al [ 46 ] demonstrated that consecutive 21-day exposure to polystyrene NPs at concentrations of 0.1 and 1 mg∙L −1 had no impact on the three investigated generations.…”

Section: Discussionmentioning

confidence: 99%

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Multigenerational Effects of Graphene Oxide Nanoparticles on Acheta domesticus DNA Stability

Flasz

Ajay

Tarnawska

et al. 2023

IJMS

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The use of nanoparticles like graphene oxide (GO) in nanocomposite industries is growing very fast. There is a strong concern that GO can enter the environment and become nanopollutatnt. Environmental pollutants’ exposure usually relates to low concentrations but may last for a long time and impact following generations. Attention should be paid to the effects of nanoparticles, especially on the DNA stability passed on to the offspring. We investigated the multigenerational effects on two strains (wild and long-lived) of house cricket intoxicated with low GO concentrations over five generations, followed by one recovery generation. Our investigation focused on oxidative stress parameters, specifically AP sites (apurinic/apyrimidinic sites) and 8-OHdG (8-hydroxy-2′-deoxyguanosine), and examined the global DNA methylation pattern. Five intoxicated generations were able to overcome the oxidative stress, showing that relatively low doses of GO have a moderate effect on the house cricket (8-OHdG and AP sites). The last recovery generation that experienced a transition from contaminated to uncontaminated food presented greater DNA damage. The pattern of DNA methylation was comparable in every generation, suggesting that other epigenetic mechanisms might be involved.

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