Reproductive toxic effects of sublethal cadmium on the marine polychaete Perinereis nuntia

Zheng, Shu-Fa; Chen, Bin; Wang, Zhen; Qiu, Xiaoyan; Yu, Xi; Freestone, David; Liu, Zhenghua; Huang, Hao; Yu, Weiwei; Xu, Xianzhong

doi:10.1016/j.ecoenv.2010.05.022

Cited by 19 publications

(5 citation statements)

References 22 publications

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“…MT mRNA expression is often used as a biomarker for metal pollution, but it is known that EDCs such as 17ß estradiol can alter MT expression in different ways (Olsson et al, 1995). High concentrations of 17ß estradiol and of Cd significantly altered the MT expression levels (Martin et al, 2003;Zheng et al, 2010;Huang et al, 2014). Elevated MT expression has also been reported for fathead minnow exposed to Cu, or to a mixture of Cu and either Cd or Ni (Driessnack et al, 2016;Driessnack et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…By stealthy seeping into ground water, such compounds enter the freshwater streams and affect cellular metabolism (Pelgrom et al, 1995). Heavy metals have been shown to alter VTG expression in different ways (Zheng et al, 2010;Huang et al, 2014). Therefore, metallothioneins (MTs) may also be valuable biomarkers not only for metal contamination but also for the presence of EDCs (Rhee et al, 2009;Huang et al, 2014;Moncaleano-Niño et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Expression of biomarkers connected to endocrine disruption in Cottus gobio and Salmo trutta fario in relation to sewage treatment plant-efflux and pesticides

Niederwanger

Josef²,

Thaler³

et al. 2022

Front. Environ. Sci.

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The increasing efflux on a large scale of organic contaminants holding endocrine disrupting activity from sewage treatment plants produces detrimental biological effects to various fish species. However, the impact of small-scale sewage treatment plant-efflux in small river streams and narrow creeks is largely unknown. Extensive pesticide output especially in vineyards and orchards also causes adverse effects on the endocrine system of wildlife fish species inhabiting nearby rivers. To elaborate whether fish species and populations in the areas of interest were at risk of experiencing endocrine disruption, we identified different biomarkers related to endocrine disruption in Cottus gobio and Salmo trutta fario and applied this approach to selected Austrian freshwater streams pre and post sewage treatment plants and permanent cultures with extensive pesticide output in South Tyrol. Overall, mRNA expression levels of vitellogenin, estrogen receptor α and zona pellucida genes in wildlife fish, compared to a control population reared under constant conditions in the laboratory were significantly increased. Sewage-treatment plant efflux did not significantly affect the mRNA expression levels while extensive use of pesticides altered mRNA expression significantly in C. gobio. C. gobio and S. trutta fario display different levels of mRNA expression. Cadmium and copper concentrations in liver tissues varied but did not indicate significant levels of contamination. Our results demonstrate the presence of endocrine disrupting chemicals in the tested freshwater streams. We anticipate our study to be a starting point for further studies focusing on the effects of endocrine disrupting chemicals on individuals and populations. Especially the fact that the two selected species reveal highly different levels of mRNA expression levels is of interest when applying biomarker approaches which can be a useful tool for monitoring projects and risk-assessment associated studies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Expression of biomarkers connected to endocrine disruption in Cottus gobio and Salmo trutta fario in relation to sewage treatment plant-efflux and pesticides

Niederwanger

Josef²,

Thaler³

et al. 2022

Front. Environ. Sci.

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“…Its half-life in human blood is of 2–3 months, however, following absorption it can reside in body tissues for years 16 . Cd and Chromium are carcinogenic in nature and are known to act as an endocrine disruptor 17 , 18 . Chronic exposure of Cr to human body imparts hazardous effects on liver, kidney and lungs and is highly toxic to biota 17 .…”

Section: Introductionmentioning

confidence: 99%

Biochemical and reproductive biomarker analysis to study the consequences of heavy metal burden on health profile of male brick kiln workers

David

Jahan

Hussain

et al. 2022

Sci Rep

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The present study aims to assess the effect of a heavy metal burden on general health, biochemical parameters, an antioxidant enzyme, and reproductive hormone parameters in adult male brick kiln workers from Pakistan. The study participants (n = 546) provided demographic data including general health as well as body mass index. Blood was collected to quantitatively assess hematological, biochemical, and reproductive hormone parameters as well as heavy metal concentrations using both atomic absorption spectroscopy (AAS) and particle-induced X-ray emission (PIXE). The data showed that 10% of the brick kiln workers were underweight and 10% obese (P = 0.059), with workers also reporting multiple health issues. Heavy metal concentrations utilizing AAS revealed significantly (p = 0.000) higher levels of cadmium, chromium, and nickel, while PIXE detected more than permissible levels of Si, P, S, Cl, K, Ca, Zn, Ti (p = 0.052), Mn (p = 0.017), Fe (p = 0.055), Co (p = 0.011), Ni (p = 0.045), and Cu (p = 0.003), in the blood of kiln workers. Moreover, a significant increase in platelet count (P = 0.010), a decrease in sodium dismutase levels (p = 0.006), a major increase in reactive oxygen species (p = 0.001), and a reduction in protein content (p = 0.013) were evident. A significant increase in cortisol levels (p = 0.000) among the workers group was also observed. The concentration of LH and FSH increased significantly (p = 0.000), while that of testosterone decreased (p = 0.000) in the worker group compared with controls. A significant inverse relationship was found between cortisol, LH (r = − 0.380), and FSH (r = − 0.946), while a positive correlation between cortisol and testosterone was also evident (r = 0.164). The study concludes that increased heavy metal burden in the blood of brick kiln workers exposes them to the development of general and reproductive health problems due to compromised antioxidant enzyme levels, increased oxidative stress conditions, and a disturbing reproductive axis.

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“…Many studies have shown that heavy metals could influence the estrogen pathway in various tissues, but some responses observed in various studies were different (Chang et al, 2011;Martin et al 2003;Søfteland et al, 2010;Vetillard and Bailhache, 2005;Zheng et al, 2010). For example, a previous study showed that Cd caused dose-dependent reproductive toxicity on Perinereis nuntia by inhibiting sexual maturation, fertilization and zygote hatching, and the increased expression of Vtg mRNA (Zheng et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…For example, a previous study showed that Cd caused dose-dependent reproductive toxicity on Perinereis nuntia by inhibiting sexual maturation, fertilization and zygote hatching, and the increased expression of Vtg mRNA (Zheng et al, 2010). But Chang et al (2011) reported that Cd did not induce Vtg protein expression in male Carassius auratus hepatocytes.…”

Section: Introductionmentioning

confidence: 99%

Expression patterns of metallothionein, cytochrome P450 1A and vitellogenin genes in western mosquitofish (Gambusia affinis) in response to heavy metals

Huang

Ying

Liang

et al. 2014

Ecotoxicology and Environmental Safety

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Reproductive toxic effects of sublethal cadmium on the marine polychaete Perinereis nuntia

Cited by 19 publications

References 22 publications

Expression of biomarkers connected to endocrine disruption in Cottus gobio and Salmo trutta fario in relation to sewage treatment plant-efflux and pesticides

Expression of biomarkers connected to endocrine disruption in Cottus gobio and Salmo trutta fario in relation to sewage treatment plant-efflux and pesticides

Biochemical and reproductive biomarker analysis to study the consequences of heavy metal burden on health profile of male brick kiln workers

Expression patterns of metallothionein, cytochrome P450 1A and vitellogenin genes in western mosquitofish (Gambusia affinis) in response to heavy metals

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