Reproductive state controls transcription in the murine liver, with implications for breast cancer liver metastasis
Michelle K. Ozaki,
Yi Zhang,
Alexandra Q. Bartlett
et al.
Abstract:Liver biology is functionally linked to lactation, as liver size and metabolic output increase during lactation to support synthesis of breast milk. Upon weaning, the rodent liver returns to baseline homeostasis via hepatocyte cell death, in a process considered liver involution. To explore liver biology changes across a lactation-wean cycle, we employed transcriptomic profiling. We identified elevated hepatocyte proliferation and anabolic metabolism gene signatures during lactation, consistent with the liver … Show more
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