In 1990, the first Teratogen Information Service in Brazil (SIAT) was implemented
in the Medical Genetics Service at Hospital de Clinicas de Porto Alegre. SIAT is
a free-to-use information service both to health professionals and the general
population, especially to women who are pregnant or planning pregnancy. The main
objective of this paper is to present the activities of SIAT in its initial
years (1990-2006), compared to those in the last decade (2007-2017). In addition
we review the scientific contribution of SIAT in the field of human
teratogenesis. Since 1990, SIAT received 10,533 calls. Use of medications were
the main reason for concern, accounting for 74% of all questions, followed by
other chemical exposures (occupational, cosmetics, environmental), and maternal
infectious diseases. Among its main contributions to scientific knowledge was
the collaboration for the identification of two new human teratogens:
misoprostol in the 1990s and Zika virus in 2015/16. In conclusion, SIAT is still
evolving, as is the Medical Genetics Service that hosts it. Through its 27 years
of existence more than 300 undergraduate and graduate students have rotated at
SIAT. Presently, SIAT is expanding the research to experimental teratogenesis
and to investigation of molecular mechanisms of teratogens.