Reproductive Risk Factors of Inflammatory Breast Cancer according to Luminal, HER2-Overexpressing, and Triple-Negative Subtypes: A Case Comparison Study

Mejri, Nesrine; Benna, Houda El; Rachdi, Haifa; Labidi, Soumaya; Benna, M.; Daoud, Nouha; Hamdi, Yosr; Abdelhak, Sonia; Boussen, Hamouda

doi:10.1159/000506691

Cited by 7 publications

(4 citation statements)

References 25 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most importantly, IBC is a NIH-designated cancer health disparity ( Institute, 2016 ) with increased global incidence and mortality in minoritized and marginalized populations ( Relation et al, 2021 , Schinkel et al, 2014 , Gudina et al, 2019 ). This is consistent with reports of distinct reproductive risk factors like younger age at first pregnancy, multiparity, and breastfeeding in IBC ( Fouad TM, 2018 ) ( Linhares et al, 2020 , Mejri et al, 2020 ). These studies highlight the significance of primary care providers (PCP), including physicians, physician assistants, and nurse practitioners, who are often the first point of contact when patients begin to notice symptoms ( Nekhlyudov et al, 2017 ).…”

Section: Introductionsupporting

confidence: 92%

Identification of barriers at the primary care provider level to improve inflammatory breast cancer diagnosis and management

Devi,

Fish,

Bennion

et al. 2023

Preventive Medicine Reports

View full text Add to dashboard Cite

Section: Introductionsupporting

confidence: 92%

Identification of barriers at the primary care provider level to improve inflammatory breast cancer diagnosis and management

Devi,

Fish,

Bennion

et al. 2023

Preventive Medicine Reports

View full text Add to dashboard Cite

“…Black women are disproportionately impacted by IBC and are more likely to be diagnosed with triple negative-IBC and a worse outcome than any other racial group. 33,[38][39][40][41][42][43] Underrepresentation of black women in our cohort precludes analysis of classic presentation by race; no significant associations were observed in our analysis, however, this limitation makes it inconclusive.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory breast cancer appearance at presentation is associated with overall survival

et al. 2021

View full text Add to dashboard Cite

Background Inflammatory breast cancer (IBC) is a clinical diagnosis. Here, we examined the association of a “classic” triad of clinical signs, swollen involved breast, nipple change, and diffuse skin change, with overall survival (OS). Method Breast medical photographs from patients enrolled on a prospective IBC registry were scored by two independent reviewers as classic (triad above), not classic, and difficult to assign. Chi‐squared test, Fisher's exact test, and Wilcoxon rank‐sum test were used to assess differences between patient groups. Kaplan–Meier estimates and the log‐rank test and Cox proportional hazard regression were used to assess the OS. Results We analyzed 245 IBC patients with median age 54 (range 26–81), M0 versus M1 status (157 and 88 patients, respectively). The classic triad was significantly associated with smoking, post‐menopausal status, and metastatic disease at presentation ( p = 0.002, 0.013, and 0.035, respectively). Ten‐year actuarial OS for not classic and difficult to assign were not significantly different and were grouped for further analyses. Ten‐year OS was 29.7% among patients with the classic sign triad versus 57.2% for non‐classic ( p < 0.0001). The multivariate Cox regression model adjusting for clinical staging ( p < 0.0001) and TNBC status (<0.0001) demonstrated classic presentation score significantly associated with poorer OS time (HR 2.6, 95% CI 1.7–3.9, p < 0.0001). Conclusions A triad of classic IBC signs independently predicted OS in patients diagnosed with IBC. Further work is warranted to understand the biology related to clinical signs and further extend the understanding of physical examination findings in IBC.

show abstract

“…Multiple animal models of mammary tumorigenesis and pregnancy have confirmed the protective effects of pregnancy in BC (Feigman et al, 2020;Hanasoge Somasundara et al, 2021). Interestingly, prolonged lactation and nursing have also been identified as key risk factors for inflammatory breast cancer (IBC), a rare and highly aggressive BC subtype (Mejri et al, 2020). On the other hand, studies have shown that short-term breast feeding and premature involution may also contribute to a "primed" stroma that is permissive to IBC (Bambhroliya et al, 2018).…”

Section: Loss Of Irf5 Expression Alters Normal Mammary Gland Developm...mentioning

confidence: 99%

Loss ofIRF5increases ribosome biogenesis leading to alterations in mammary gland architecture and metastasis

Brune

et al. 2023

Preprint

View full text Add to dashboard Cite

Despite the progress made in identifying cellular factors and mechanisms that predict progression and metastasis, breast cancer remains the second leading cause of death for women in the US. Using The Cancer Genome Atlas and mouse models of spontaneous and invasive mammary tumorigenesis, we identified that loss of function of interferon regulatory factor 5 (IRF5) is a predictor of metastasis and survival. Histologic analysis of Irf5-/- mammary glands revealed expansion of luminal and myoepithelial cells, loss of organized glandular structure, and altered terminal end budding and migration. RNA-seq and ChIP-seq analyses of primary mammary epithelial cells from Irf5+/+ and Irf5-/- littermate mice revealed IRF5-mediated transcriptional regulation of proteins involved in ribosomal biogenesis. Using an invasive model of breast cancer lacking Irf5, we demonstrate that IRF5 re-expression inhibits tumor growth and metastasis via increased trafficking of tumor infiltrating lymphocytes and altered tumor cell protein synthesis. These findings uncover a new function for IRF5 in the regulation of mammary tumorigenesis and metastasis.

show abstract

Reproductive Risk Factors of Inflammatory Breast Cancer according to Luminal, HER2-Overexpressing, and Triple-Negative Subtypes: A Case Comparison Study

Cited by 7 publications

References 25 publications

Identification of barriers at the primary care provider level to improve inflammatory breast cancer diagnosis and management

Identification of barriers at the primary care provider level to improve inflammatory breast cancer diagnosis and management

Inflammatory breast cancer appearance at presentation is associated with overall survival

Loss ofIRF5increases ribosome biogenesis leading to alterations in mammary gland architecture and metastasis

Contact Info

Product

Resources

About