Reproductive Performance of Women With Müllerian Anomalies

Rackow, Beth W.; Arıcı, Aydın

doi:10.1097/01.pgo.0000303290.56202.97

Cited by 59 publications

(105 citation statements)

References 64 publications

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“…And in women who have suffered from recurrent spontaneous abortion, the rate of MDA could rise to 15 %. Most MDA cases are sporadic, but family aggregates in MDA, especially in MRKH, exhibit a strong relationship to recurrence in female first-degree relatives [23]. Although the genetic etiologies and inheritance patterns of MDA are still obscure, it has been postulated that MDA is a multifactor/polygenic disorder [6].…”

Section: Discussionmentioning

confidence: 99%

Genetic association between PAX2 and mullerian duct anomalies in Han Chinese females

Xing

et al. 2016

J Assist Reprod Genet

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Purpose The study aims to investigate the genetic association between paired box gene 2 (PAX2) and mullerian duct anomalies (MDA) in Chinese Han females. Methods Matrix-assisted laser desorption/ionization time-offlight mass spectrometry (MALDI-TOF MS) was used to identify the genotypes of three tag single nucleotide polymorphisms (SNPs) in PAX2 in 362 MDA cases and 406 controls. Results We found that one tag SNP (rs12266644) of PAX2 was associated with susceptibility to MDA. The genotype distributions of the SNP rs12266644 have a statistically significant difference in the MDA patients and controls with a p value = 0.008. In the dominant model, we also observed that the GT + TT genotype increased the risk for MDA (p = 0.015, OR = 1.637, 95 % CI = 1.096-2.443). Conclusion The polymorphism rs12266644 of PAX2 might be a risk factor for MDA in Chinese Han females.

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Section: Discussionmentioning

confidence: 99%

Genetic association between PAX2 and mullerian duct anomalies in Han Chinese females

Xing

et al. 2016

J Assist Reprod Genet

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“…Unicornuate uterus with a rudimentary horn is a rare mullerian anomaly that has a high incidence of obstetric complications that include ectopic pregnancy in the rudimentary horn. 1 Pregnancy in non-communicating rudimentary horn is possible by trans-peritoneal migration of sperm or fertilized ovum. It occurs in approximately 1 of every 76,000 pregnancies.…”

Section: Introductionmentioning

confidence: 99%

“…The risk of uterine rupture is 50-90%, with most ruptures (approximately 80%) occurring by the end of the second trimester. [1][2][3] We report our experience in diagnosing and managing a case of fetal death in a rudimentary horn which was missed on routine malformation scan.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy in non-communicating rudimentary horn

Deora

Chawla

Shetty

2017

Int J Reprod Contracept Obstet Gynecol

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A 25-year old G3P2L2 presented to casuality of OBG Dept, Ummaid Hospital, Jodhpur with5 months amenorrhea and bleeding per vaginum for last 5 days associated with abdominal pain. On per abdomen examination, a mass arising from pelvis corresponding to the size of a 16 weeks pregnancy was seen. A repeat ultrasound was performed in our hospital and the findings were - normally visualised uterus with a gestational sac with thin myometrium rim seen on right side with single dead fetus of gestational age 14 weeks 3 days, pregnancy in rudimentary horn, bicornuate uterus with pregnancy in right horn. Patient was counselled and prepared for laparotomy which was performed under general anesthesia. Intra -operative findings were normal sized uterus, right sided rudimentary horn pregnancy was seen. Both tubes and ovaries were normal. Hence, right sided rudimentary horn excision along with ipsilateral salpingo – oophorectomy was planned and done by clamping and cutting. Hemostasis was achieved. There was no communication between the rudimentary horn and the main uterus. The estimated blood loss was 200ml.

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“…uterine activity and cervical dilation result in the cascade of events which are underlying. [3][4][5][6] To evaluate the risk of preterm birth was usually done by measuring the cervical length and detecting cervical funneling. Clinical diagnosis of preterm labor is unreliable because it is very subjective.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of uterine cervix with transvaginal ultrasonography in women with threatened preterm labor and or preterm labor

Shree¹,

Chitra²

2018

Int J Reprod Contracept Obstet Gynecol

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Background: Preterm delivery can be associated with substantial perinatal morbidity and mortality. Nearly in 5 to 13% of pregnancies, happening deliveries are preterm before 37 weeks' gestation. Thus, prediction of preterm labor in parturient can provide a window of opportunity to prevent these complications and to be better prepared to deal with them. Hence the current study has been conducted with an objective to assess the efficiency of cervical length and funneling as assessed by transvaginal ultrasonography in predicting preterm labor.Methods: The current study was a prospective study, conducted in the Department of Obstetrics Emergencies, Dhanalakshmi Srinivasan Medical College and Hospital between November 2015 to April 2017. The study population included 60 women with singleton pregnancy of gestational age between 28 + 0 and 36 + 6 weeks and with painful and regular contractions (>1/10 min for at least 1 hour). Cervical length, funnelling length measured at presentation and after 48 hours were considered as predictor variables. The outcomes of interest were delivery within 1 week, delivery before 37 weeks and delivery before 34 weeks.Results: There was a statistically significant difference in cervical length and funnelling length between term and preterm groups at the time of diagnosis and after 48 hours (P <0.001). The positive predictive value increased from 33.3% to 100% with cervical length ≤ 40 mm to ≤ 20 mm. The negative predictive value decreased from 100% to 79.2% with cervical length ≤40 mm to ≤20 mm. To predict a preterm delivery in threatened preterm delivery patients, the sensitivity of a cervical length of ≤25 mm was 77.7%, specificity was 95.2%, the positive predictive value was 87.5% and negative predictive value is 90.9%.Conclusions: Cervical length and funnelling as assessed by transvaginal ultrasonography are efficient in predicting preterm labor.

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Reproductive Performance of Women With Müllerian Anomalies

Cited by 59 publications

References 64 publications

Genetic association between PAX2 and mullerian duct anomalies in Han Chinese females

Genetic association between PAX2 and mullerian duct anomalies in Han Chinese females

Pregnancy in non-communicating rudimentary horn

Evaluation of uterine cervix with transvaginal ultrasonography in women with threatened preterm labor and or preterm labor

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