Reproductive performance after hysteroscopic metroplasty in the hypoplastic uterus: a study of 29 cases

Abstract

Objective To evaluate the reproductive performance after hysteroscopic metroplasty performed for hypoplastic uterus. Design Crossover study (15 patients) and descriptive analysis (14 patients).Setting Tertiary care university hospital.Population Twenty-nine women (mean age: 31.4 years; range: 27 -38.5 years) with a hypoplastic malformed uterus and a history of primary infertility and/or recurrent abortion and/or preterm delivery were included in this study. Fourteen women suffered from primary infertility and 15 women had previous pregnancies. Twenty-three women had been exposed to diethylstilboestrol in utero. Methods Women underwent hysteroscopic metroplasty between January 1996 and May 1999. Main outcome measures Rate of pregnancies and live births, anatomical results.Results The mean follow up was 40 months (range: 13 -67 months). Twenty-one women (72.4%) experienced 30 pregnancies. Thirteen women gave birth to 16 live infants. At the time of the follow up, four women were pregnant in the second trimester. Compared with previous pregnancies, the rate of deliveries increased from 3.8% to 63.2%. No complications occurred during metroplasty. The hysteroscopic anatomical results were good in all cases. Conclusions Our results suggest that hysteroscopic metroplasty, with its simplicity and minimal postoperative sequelae, seems to be an operation of choice in women with a hypoplastic malformed uterus and a history of severe infertility and/or recurrent pregnancy loss.

The Expression of Apolipoprotein A1 on Pregnancy Outcome in Women with Polycystic Ovary Syndrome Compared to Fertile Women: A Cross-Sectional Study

“…Despite many recent advances in assisted reproduction techniques even with the selection of good quality embryos, the rate of success is mainly limited because of implantation failures [7,8,16] Endometrial factors at the molecular level have been suggested to explain implantation failure and poor reproductive potential of patients with polycystic ovary syndrome [1,7].…”

“…Prevalence of this condition in women of the reproductive age is approximately between 5% and 10% [1,4,5]. Polycystic ovary syndrome as a complex disorder is associated with several health complications including obesity, hyperandrogenism, metabolic syndrome, hirsutism, acne, ovarian dysfunction, and infertility [4,6,7]. Although anovulation is an obvious cause of infertility in polycystic ovary syndrome, growing evidence suggests that endometrial receptivity also contributes to infertility of these patients [1,7,8].…”

Apo-lipoprotein A1 in the Endometria of Patients with Polycystic Ovary Syndrome

“…Hence, the ApoB/ApoA1 ratio reflects the status of pro-and antiatherogenic lipoproteins, and is a marker of MS and CVD [4][5][6][7][8][9][10].…”

Validity of Hysteroscopy in Detection of Uterine Cavity Abnormalities in Women with Recurrent Pregnancy Loss

“…Most of the defects are treatable [6]. Rates of conception after hysteroscopic metroplasty in septate uterus, or hysteroscopic cutting of intra-uterine adhesion are stated to be high with 87% conception rate postoperatively [7].…”