Reproductive Outcomes in Patients With Intrauterine Adhesions Following Hysteroscopic Adhesiolysis: Experience From the Largest Women's Hospital in China

Chen, Limei; Zhang, Hongwei; Wang, Qing; Xie, Feng; Gao, Shujun; Song, Yu; Dong, J.; Feng, Hua; Xie, Keqin; Sui, Long

doi:10.1016/j.jmig.2016.10.018

Cited by 112 publications

(88 citation statements)

References 19 publications

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“…One study reported that the live birth rate after hysteroscopic treatment was 63.7% (79/124) with 14-year follow-up [35], whereas the live birth rate in our series was 53.1% (68 /128), which may be in part due to the shorter duration of follow-up. Another study from one hospital in China, with the similar inclusion criteria and management of IUA to our study, reported a similar live birth rate of 42.2% (140/332) as in our study after following up for 27±9 months [36]. A pooled live birth rate, 46.3% (696/1504), was reported from a systematic review containing 36 studies, which was also similar to our study [37].…”

Section: Discussionsupporting

confidence: 89%

Predictive Value of Live Birth Rate Based on Different Intrauterine Adhesion Evaluation Systems Following

Cao

Pan

Zhang

et al. 2020

Preprint

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Objective: The aim of this study was to assess the predictive value of five different intrauterine adhesion (IUA) evaluation systems for live birth rate following transcervical resection of adhesion (TCRA).Method: This retrospective study included 128 women with IUA who desired for spontaneous conception after TCRA. All the patients were retrospectively scored by the American Fertility Society (AFS) classification, European Society of Gynecological Endoscopy (ESGE) classification, March’s classification (March), Nasr’s classification (Nasr) and Chinese IUA diagnosis classification criteria (Chinese). The predictive value of these evaluation systems was determined by receiver operating characteristic (ROC) curves and area under a ROC curve (AUC).Results: The correlation coefficients of AFS, ESGE, March, Nasr and Chinese classification and the live birth rate were 0.282, 0.324, 0.260, 0.418, 0.364, respectively. All five scoring systems were efficient to predict live birth rate. Among them, Nasr’s classification showed the highest AUC (0.748) with the best predictive value.Conclusion: AFS, ESGE, March, Nasr and Chinese classification were demonstrated to be capable of predicting live birth following TCRA, and Nasr’s classification showed the highest predictive value of live birth.

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Section: Discussionsupporting

confidence: 89%

Predictive Value of Live Birth Rate Based on Different Intrauterine Adhesion Evaluation Systems Following

Cao

Pan

Zhang

et al. 2020

Preprint

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“…Additionally, hormone therapy is needed to regain the uterine lining. However, there is a chance that the adhesions will be recurrent, even after adhesiolysis, depending on the severity of the disease . What's more, there are complications that can still affect a patient even after a successful pregnancy, such as abnormal placentation, preterm delivery, intrauterine growth restrictions, and higher rates of caesarean sections .…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell‐Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

Liu

Yang

et al. 2019

Adv Healthcare Materials

117

108

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Stem cell therapies have made strides toward the efficacious treatment of injured endometrium and the prevention of intrauterine adhesions, or Asherman's syndrome (AS). Despite this progress, they are limited by their risk of tumor formation, low engraftment rates, as well as storage and transportation logistics. While attempts have been made to curb these issues, there remains a need for simple and effective solutions. A growing body of evidence supports the theory that delivering media, conditioned with mesenchymal stem cells, might be a promising alternative to live cell therapy. Mesenchymal stem cell‐secretome (MSC‐Sec) has a superior safety profile and can be stored without losing its regenerative properties. It is versatile enough to be added to a number of delivery vehicles that improve engraftment and control the release of the therapeutic. Thus, it holds great potential for the treatment of AS. Here, a new strategy for loading crosslinked hyaluronic acid gel (HA gel) with MSC‐Sec is reported. The HA gel/MSC‐Sec treatment paradigm creates a sustained release system that repairs endometrial injury in rats and promotes viable pregnancy.

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“…Recurrence following surgery is a major challenge with adhesiolysis and is seen most often in severe cases and with adhesions located close to the uterine cornua . To reduce the risk of recurrence, estrogen therapy and an intrauterine balloon catheter have been used successfully .…”

Section: Discussionmentioning

confidence: 99%

Audit of operative hysteroscopies among infertile women in a resource‐poor setting

Ugboaja

Oguejiofor

Ogelle³

2018

Intl J Gynecology & Obste

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Reproductive Outcomes in Patients With Intrauterine Adhesions Following Hysteroscopic Adhesiolysis: Experience From the Largest Women's Hospital in China

Cited by 112 publications

References 19 publications

Predictive Value of Live Birth Rate Based on Different Intrauterine Adhesion Evaluation Systems Following

Predictive Value of Live Birth Rate Based on Different Intrauterine Adhesion Evaluation Systems Following

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell‐Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

Audit of operative hysteroscopies among infertile women in a resource‐poor setting

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