Reproductive outcomes in DDT applicators

Cocco, Pierluigi; Fadda, Daniela; Ibba, Antonio; Melis, Maria Teresa; Tocco, Maria Giuseppina; Atzeri, S; Avataneo, Giuseppe; Meloni, Mauro; Monni, Filippo; Flore, C

doi:10.1016/j.envres.2004.09.007

Cited by 37 publications

(22 citation statements)

References 25 publications

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“…Toft et al (2005), INUENDO group, showed that fecundability is inversely related with serum concentration of p,p'DDE. Cocco et al (2005) concluded that the fecundity ratio among spouses of DDT applicators compare to the unexposed was decreased, but the low statistical power of the study did not allow definitive conclusions. Cohn et al (2003) measured serum levels of DDT and DDE in mothers and evaluated TTP in their daughters.…”

Section: Pesticide Exposure and Health Related Issues In Male And Femmentioning

confidence: 99%

Pesticide Exposure and Health Related Issues in Male and Female Reproductive System

Sifakis¹,

Mparmpas²,

Tsatsakis³

2011

Pesticides - Formulations, Effects, Fate

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Section: Pesticide Exposure and Health Related Issues In Male And Femmentioning

confidence: 99%

Pesticide Exposure and Health Related Issues in Male and Female Reproductive System

Sifakis¹,

Mparmpas²,

Tsatsakis³

2011

Pesticides - Formulations, Effects, Fate

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“…Although banned in the 1970s in North America and Europe, they are still used in some countries [1,2]. Occupational exposure has been associated with hormonal and reproductive disruption [3][4][5] as well as immune dysfunctions [6]. Nonoccupational exposure of the general human population has been of increasing concern over the last several decades based on the awareness that many chemicals have been inadequately tested with regard to safety and the increasing sophistication of toxicology.…”

Section: Introductionmentioning

confidence: 98%

Heptachlor and o‐p′DDT effects on protein kinase activities associated with human placenta particulate fractions

Magnarelli

Souza

D’Angelo

2009

J Biochem & Molecular Tox

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Organochlorine pesticides have been detected in placenta. The ability of heptachlor (HC) and 1,1,1-tricholoro-2-(2-chlorophenyl)-2-4-chlorophenyl)ethane (o-p'DDT) to interfere with protein phosphorylation was evaluated. In vitro incubations of cell-free placental villi homogenates with a concentration range 1-100 microM were performed. In particulate fractions, total serine/threonine kinase activity was increased by 10 microM HC and o-p' DDT (59% and 82%, respectively). Maximum eightfold increase was observed with 10 microM o-p' DDT on protein kinase A activity. By contrast, protein kinase C activity was reduced by 10 microM HC and o-p' DDT (40% and 52%, respectively). Endogenous substrate phosphorylation studies demonstrated that slight but significant increase in 24-kDa band labeling was produced in nuclear samples with 1, 10, and 100 microM HC and 100 microM o-p' DDT. Exposition to 100 microM HC increased 85-kDa band labeling. In mitochondrial fractions, 10 microM HC and o-p' DDT increased 24- and 65-kDa bands' labeling. These data indicate that both pesticides affect protein kinase activities in particulate fraction. Nuclear compartmentalization of these compounds, insertion in membranes, and chemical stress production may be associated to the observed effects, thus suggesting deleterious consequences in signaling pathways.

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“…There is some evidence from human studies that exposure to POPs, many of which are known endocrine disruptors, may increase the risk of certain cancers, such as non-Hodgkin lymphoma (Colt et al 2005; Engel et al 2007), pancreatic cancer (Hardell et al 2007; Hoppin et al 2000; Porta et al 1999), and prostate cancer (Ritchie et al 2003). In addition, POP exposures have been associated with autoimmune diseases (Powell et al 1999), diabetes, (Longnecker and Daniels 2001), developmental neurotoxicity (Kakeyama and Tohyama 2003; Seegal 1996; Tilson and Kodavanti 1998; Winneke et al 2002), and adverse reproductive end points, such as spontaneous abortion (Korrick et al 2001; Longnecker et al 2005; Venners et al 2005), birth defects (Salazar-Garcia et al 2004), and impaired male fertility (Cocco et al 2005; Pflieger-Bruss et al 2004). However, the mechanisms by which POPs can lead to these diseases and adverse outcomes are not well characterized.…”

mentioning

confidence: 99%

Global DNA Hypomethylation Is Associated with High Serum-Persistent Organic Pollutants in Greenlandic Inuit

Rusiecki

Baccarelli

Bollati

et al. 2008

Environ Health Perspect

320

228

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BackgroundPersistent organic pollutants (POPs) may influence epigenetic mechanisms; therefore, they could affect chromosomal stability and gene expression. DNA methylation, an epigenetic mechanism, has been associated with cancer initiation and progression. Greenlandic Inuit have some of the highest reported POP levels worldwide.ObjectiveOur aim in this study was to evaluate the relationship between plasma POPs concentrations and global DNA methylation (percent 5-methylcytosine) in DNA extracted from blood samples from 70 Greenlandic Inuit. Blood samples were collected under the Arctic Monitoring and Assessment Program and previously analyzed for a battery of POPs.MethodsWe used pyrosequencing to estimate global DNA methylation via Alu and LINE-1 assays of bisulfite-treated DNA. We investigated correlations between plasma POP concentrations and global DNA methylation via correlation coefficients and linear regression analyses.ResultsWe found inverse correlations between percents methylcytosine and many of the POP concentrations measured. Linear regressions, adjusting for age and cigarette smoking, showed statistically significant inverse linear relationships mainly for the Alu assay for p,p′-DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane; β = −0.26), p,p′-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene; β = −0.38], β-hexachlorocyclohexane (β = −0.48), oxychlordane (β = −0.32), α-chlordane (β = −0.75), mirex (β = −0.27), sum of polychlorinated biphenyls (β = −0.56), and sum of all POPs (β = −0.48). Linear regressions for the LINE-1 assay showed β estimates of similar magnitudes to those using the Alu assay, however, none was statistically significant.ConclusionsThis is the first study to investigate environmental exposure to POPs and DNA methylation levels in a human population. Global methylation levels were inversely associated with blood plasma levels for several POPs and merit further investigation.

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Reproductive outcomes in DDT applicators

Cited by 37 publications

References 25 publications

Pesticide Exposure and Health Related Issues in Male and Female Reproductive System

Pesticide Exposure and Health Related Issues in Male and Female Reproductive System

Heptachlor and o‐p′DDT effects on protein kinase activities associated with human placenta particulate fractions

Global DNA Hypomethylation Is Associated with High Serum-Persistent Organic Pollutants in Greenlandic Inuit

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