The problem of male infertility particularly affects men with HIV infections, as semen volume and sperm motility are reduced by highly active antiretroviral therapy. Purpose of the study: to analyze the metabolic parameters of spermatozoa, spermograms and spermatozoa morphology in HIV-infected men. The material was taken and the ejaculate was examined according to standardized methods proposed by WHO experts. In HIV-infected men, spermatozoa motility was low (the number of progressively motile spermatozoa was 28.53.72%), the spermatozoa concentration was two times lower compared to the control group of men, the morphological characteristics of spermatozoa were significantly worse than in the control group. : most often pathology of the head (21.751.10) and neck of the spermatozoon (22.301.18) was detected, which negatively affects the fertilizing ability. In HIV-infected men, changes in metabolic metabolism were noted: the activity of creatine phosphokinase in both sperm plasma (661.951.08 U/l) and blood plasma (76.901.09 U/l) was lower, than in the control group (844.250.13 U/l and 79.501.37 U/l, respectively), the glucose level (8.071.14 mmol/l) was 2 times higher than in the control group (3.061.09 mol/l), the concentration of calcium 6.530.01 and sodium (119.201.23 mol/l) slightly exceeded those in the group of healthy patients (5.55 0.08 mol/l and 116.850.01 mol/l, respectively). Electron microscopic analysis revealed fragmentation of sperm DNA: the highest percentage of sperm with fragmented DNA was found in men with HIV infection (more than 23%).