Reproductive issues in anorexia nervosa

Hoffman, Elizabeth R.; Zerwas, Stephanie; Bulik, Cynthia M.

doi:10.1586/eog.11.31

Cited by 35 publications

(22 citation statements)

References 129 publications

(180 reference statements)

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“…The lifetime prevalence of AN has been estimated between 0.3 and 1.2% . Patients suffering from AN have a disturbed conscious and unconscious mental representation of their body, leading to a strong tendency for severe food restriction and purging behavior …”

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confidence: 99%

“…2,3 Patients suffering from AN have a disturbed conscious and unconscious mental representation of their body, 4 leading to a strong tendency for severe food restriction and purging behavior. 5 An adverse consequence of starvation is severe malnutrition. Converging evidence suggests that prolonged food restriction and extreme weight loss occurring in AN are associated with global cerebral atrophy and concomitant cognitive deficits.…”

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confidence: 99%

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Preventing Wernicke's encephalopathy in anorexia nervosa: A systematic review

Oudman

Wijnia

Oey

et al. 2018

Psychiatry Clin Neurosci

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Anorexia nervosa (AN) is a common eating disorder that affects 2.9 million people worldwide. Not eating a balanced diet or fasting can cause neurological complications after severe vitamin B1 malnourishment, although the precise signs and symptoms of Wernicke's encephalopathy (WE) are not clear. Our aim was to review the signs and symptoms of WE in patients with AN. We searched MEDLINE, EMBASE, Scopus, and PiCarta on all case descriptions of WE following AN. All case descriptions of WE in AN, irrespective of language, were included. Twelve WE cases were reviewed, suggesting that WE following AN is still a relatively rare neuropsychiatric disorder. WE is characterized by a triad of: mental status change, ocular signs, and ataxia. In alcoholism, this triad is present in 16% of cases, but eight out of 12 AN cases presented themselves with a full triad of symptomatology. Importantly, patients often had a more complex triad than has been previously described, involving vertigo, diplopia, and the consequences of refeeding syndrome. The development of a full triad and additional symptomatology suggests a late recognition of signs and symptoms of WE in AN. A complicating factor is the overlap between symptoms of thiamine deficiency and the symptoms of WE. Specifically, patients who show rapid weight loss are vulnerable for the development of WE. Eating disorders, such as AN, can lead to WE. Prophylactic thiamine checks and treatment in patients with AN are relevant, and in case of suspicion of WE, adequate parenteral thiamine supplementation is necessary.

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confidence: 99%

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confidence: 99%

Preventing Wernicke's encephalopathy in anorexia nervosa: A systematic review

Oudman

Wijnia

Oey

et al. 2018

Psychiatry Clin Neurosci

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“…The number of participants in this analysis was however small so further conclusions from this finding should be drawn with caution. We had no data on maternal EDs that could predispose to preterm birth and eating disorder symptoms in the offspring; adjustment for maternal BMI as a proxy did not, however, change the results. Puberty hormones present one growing line of interest in the study of the etiology of EDs.…”

Section: Discussionmentioning

confidence: 97%

Body image and eating behavior in young adults born preterm

Matinolli

Männistö

Sipola-Leppänen

et al. 2016

Intl J Eating Disorders

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Objective Previous studies have suggested that people born preterm have increased rates of eating disorders (ED). However, a recent study suggested lower levels of ED‐related symptoms in the extreme group of adults born preterm with very low birth weight (<1,500 g). We examined symptoms related to EDs in adults born early (<34 weeks of gestational age) or late (34 to <37 weeks of gestational age) preterm. Methods We studied young adults (mean age 24.1 years) from two birth cohorts: ESTER (Northern Finland 1985–1989) and AYLS (Uusimaa, Finland, 1985–1986). Of the participants, 185 were born early preterm, 348 late preterm, and 637 were term‐born controls (N = 1,170). They completed three subscales of the Eating Disorder Inventory (EDI)−2, including Drive for Thinness (DT), Body Dissatisfaction (BD), and Bulimia (B). Group differences were examined by linear regression. Results Young women born early preterm scored 4.1 points (95% CI −8.0, −0.2, P =.04) lower in summed EDI subscale scores than women born at term, when adjusted for age and cohort. This difference was observed also in DT and BD but not for B subscales. The differences persisted after adjustments for current, pre‐ and neonatal characteristics. We did not observe differences in EDI scores among men or women born late preterm when compared to controls. Discussion Women born early preterm have significantly fewer symptoms related to EDs in early adulthood when compared to their peers born at term, which may protect from developing an ED. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:572–580)

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“…The offspring of females with EDs have an impaired stress tolerance and suffer higher risks to develop EDs, diabetes mellitus, hypertension, and heart disease later in life themselves (Easter et al, ; Easter et al, ; Hoffman, Zerwas, & Bulik, ). The occurrence of AN later in life has been shown to be independently predicted by multiple births and lower gestational weight of the offspring per extra week of gestation following a clear dose–response pattern, whereas higher birth weight for gestational age has been shown to display a strong, positive dose–response association with later‐in‐life BN (Goodman, Heshmati, Malki, & Koupil, ).…”

Section: The Clinical Problemmentioning

confidence: 99%

Clinical management of females seeking fertility treatment and of pregnant females with eating disorders

Paslakis

Zwaan

2019

Euro Eating Disorders Rev

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The presence of eating disorders (EDs) might have a significant impact upon pregnancy, birth, and the offspring's well‐being. Thus, several specific aspects are to be considered by medical professionals when females with EDs either become pregnant or intend to undergo fertility treatment. Clinical management algorithms for gynaecologists and fertility specialists are missing. Here, based on currently available evidence on the topic, specific clinical recommendations are presented. Treatment by a mental health professional may be necessary for pregnant females suffering from acute EDs or prior to fertility treatment. Because the regulation of the menstrual cycle is known to be induced in the course of ED‐specific treatment due to weight gain and eating behaviour stabilization, the necessity and drawbacks of fertility treatments in females with EDs are discussed.

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Reproductive issues in anorexia nervosa

Cited by 35 publications

References 129 publications

Preventing Wernicke's encephalopathy in anorexia nervosa: A systematic review

Preventing Wernicke's encephalopathy in anorexia nervosa: A systematic review

Body image and eating behavior in young adults born preterm

Clinical management of females seeking fertility treatment and of pregnant females with eating disorders

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