Reproductive Hormones Modulate Oxidative Stress in Alzheimer's Disease

Barron, Anna M.; Fuller, Stephanie J.; Verdile, Giuseppe; Martins, Ralph N.

doi:10.1089/ars.2006.8.2047

Cited by 46 publications

(20 citation statements)

References 146 publications

(188 reference statements)

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“…In humans, oxidative stress is thought to be involved in many diseases, such as atherosclerosis, liver disease, Parkinson's disease, Alzheimer's disease and ageing [57,58] . However, reactive oxygen species can also be beneficial, as they are used by the immune system as a way to attack and kill pathogens and by the cell as signaling molecules.…”

Section: Oxidative Stress and Hccmentioning

confidence: 99%

Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets

Severi¹,

Malenstein²,

Verslype³

et al. 2010

Acta Pharmacol Sin

157

125

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Section: Oxidative Stress and Hccmentioning

confidence: 99%

Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets

Severi¹,

Malenstein²,

Verslype³

et al. 2010

Acta Pharmacol Sin

157

125

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“…Testosterone was able to protect from OS and cell damage in the striatum, induced by ovariectomy (via caspase-3) and further increased by administration of 3-nitropropionic acid [30]. These studies are of fundamental importance for the investigation of neurodegenerative disorders, since OS has been implicated in the development of Alzheimer's disease, Parkinson disease and amyotrophic lateral sclerosis [31].…”

Section: Discussionmentioning

confidence: 91%

Effects of Intramuscular or Bioadhesive Buccal Testosterone Treatment on Antioxidant Systems in Secondary Hypogonadism

Raimondo¹

2013

J Steroids Horm Sci

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“…Studies have demonstrated that Alzheimer's disease (AD) patients have elevated serum and neuronal levels of LH as compared to controls (Barron et al 2006). Brain regions affected by AD show elevated expression of LH receptors (Casadesus et al 2005).…”

Section: Discussionmentioning

confidence: 99%

“…In cell cultures, LH stimulates amyloid beta production, a key element in oxidative stress leading to AD pathology. LH receptors are also found on immune cells where they are associated with neuroprotection and a role in the proinflammatory signaling process in the brain (Barron et al 2006). Thus, the association between I-Hg deposition and LH provides a mechanistic link between chronic mercury exposure and associated disease.…”

Section: Discussionmentioning

confidence: 99%

Assessment of chronic mercury exposure within the U.S. population, National Health and Nutrition Examination Survey, 1999–2006

Laks

2009

Biometals

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The purpose of this study was to assess chronic mercury exposure within the US population. Time trends were analyzed for blood inorganic mercury (I-Hg) levels in 6,174 women, ages 18-49, in the NHANES, 1999-2006 data sets. Multivariate logistic regression distinguished a significant, direct correlation within the US population between I-Hg detection and years since the start of the survey (OR = 1.49, P < 0.001). Within this population, I-Hg detection rose sharply from 2% in 1999-2000 to 30% in 2005-2006. In addition, the population averaged mean I-Hg concentration rose significantly over that same period from 0.33 to 0.39 μ/L (Anova, P < 0.001). In a separate analysis, multivariate logistic regression indicated that I-Hg detection was significantly associated with age (OR = 1.02, P < 0.001). Furthermore, multivariate logistic regression revealed significant associations of both I-Hg detection and mean concentration with biomarkers for the main targets of mercury deposition and effect: the liver, immune system, and pituitary. This study provides compelling evidence that I-Hg deposition within the human body is a cumulative process, increasing with age and in the population over time, since 1999, as a result of chronic mercury exposure. Furthermore, our results indicate that I-Hg deposition is associated with the significant biological markers for main targets of exposure, deposition, and effect. Accumulation of focal I-Hg deposits within the human body due to chronic mercury exposure provides a mechanism which suggests a time dependent rise in the population risks for associated disease.

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Reproductive Hormones Modulate Oxidative Stress in Alzheimer's Disease

Cited by 46 publications

References 146 publications

Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets

Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets

Effects of Intramuscular or Bioadhesive Buccal Testosterone Treatment on Antioxidant Systems in Secondary Hypogonadism

Assessment of chronic mercury exposure within the U.S. population, National Health and Nutrition Examination Survey, 1999–2006

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