Reproductive History and Oral Contraceptive Use in Relation to Risk of Triple-Negative Breast Cancer

Phipps, Amanda I.; Chlebowski, Rowan T.; Prentice, Ross L.; McTiernan, Anne; Wactawski‐Wende, Jean; Kuller, Lewis H.; Adams‐Campbell, Lucile L.; Lane, Dorothy S.; Stefanick, Marcia L.; Vitolins, Mara Z.; Kabat, Geoffrey C.; Rohan, Thomas E.; Li, Christopher I.

doi:10.1093/jnci/djr030

Cited by 194 publications

(207 citation statements)

References 33 publications

(41 reference statements)

Supporting

Mentioning

184

Contrasting

Unclassified

Order By: Relevance

“…12,13,20,46 The HR1 HER22 subtype, which represented an estrogen-derived gene-expression profile, was thought to be more sensitive to hormone exposure. 47 Furthermore, because of endocrinological and environmental changes of the breast before and after pregnancy, the endogenous estrogen exposure before FFTP could be more important than the lifetime endogenous estrogen exposure.…”

Section: Discussionmentioning

confidence: 99%

“…Although it has been known that nonbreastfeeding increases breast cancer risk, 48 the heterogeneity of associations between breastfeeding and tumor subtypes have been unclear in previous case-case and casecontrol studies. 18,20,46 Because the tumor subtypes of the study population were obtained from two recruiting centers, one limitation of our study is that there might be misclassification bias. However, it was confirmed that the same value of IHC or FISH was used to define the ER, PR and HER2 statuses and that the analyses were adjusted taking into account the recruiting centers in our study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Heterogeneity of epidemiological factors by breast tumor subtypes in Korean women: A case-case study

et al. 2014

View full text Add to dashboard Cite

Breast cancer is heterogeneous in clinical behavior by subtypes; however, it is unclear how this heterogeneity is related to epidemiological factors. To evaluate the differences in epidemiological factors by breast tumor subtypes, we investigated the associations of epidemiological factors between tumor subtypes in Korean women. From the Seoul Breast Cancer Study, a total of 3,058 patients with breast cancer were included in the analyses. Tumor subtypes were classified based on hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) statuses. The epidemiological factors of each subtype were compared through case-case analyses using multivariate a polytomous logistic regression model adjusted for age and recruiting centers. The distribution of the subtypes was as follows: 1,714 HR1 HER22 (56.0%), 414 HR1 HER21 (13.5%), 423 HR2 HER21 (13.9%) and 507 HR2 HER22 (16.6%) patients with breast cancer. There were significant differences in age, menopausal status, age at menarche, number of children, age at first full-term pregnancy (FFTP), duration of breastfeeding and duration of endogenous estrogen exposure between tumor subtypes (p < 0.05). Compared to HR1 HER22 patients, the other subtype patients showed more frequency in having more numbers of children and less frequency in having earlier menarche, later FFTP and longer endogenous estrogen exposure. Although HR2 HER21 patients were less obese, HR2 HER22 patients were younger and more obese. In conclusion, age, body mass index and reproductive factors were differentially associated with breast tumor subtypes suggesting a possible distinct etiology for tumor progression.Breast cancer is a heterogeneous disease in terms of clinical behavior. Breast tumors have been classified into intrinsic subtypes using gene expression patterns measured by microarrays.1-3 The intrinsic subtypes were explained as the clinicopathological definition based on the expression of estrogen and progesterone receptors (ER and PR), human epidermal growth factor receptor 2 (HER2) and For the basallike subtype of breast cancer, epidermal growth factor receptor (EGFR) and cytokeratin 5/6 (CK 5/6) were also used as surrogates.5 These tumor subtypes have shown significant differences in their clinical features. 2,3,6 Notwithstanding the clinical heterogeneity of the tumor subtype, the etiological heterogeneity has not been established.7 Through previous epidemiological studies, several reproductive factors, such as early menarche, late menopause and late age at first full-term pregnancy (FFTP), and family history have been established as risk factors of breast cancer, and obesity has been probable as protective or a risk factor of breast cancer depending on the menopausal status. [8][9][10] Furthermore, well-known risk factors of breast cancer have been associated with the ER-positive subtype rather than the ER-negative subtype.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Heterogeneity of epidemiological factors by breast tumor subtypes in Korean women: A case-case study

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Neste sentido, os exames frequentemente propostos visam a analisar os locais mais acometidos por metástase a distância no câncer primário da mama, sendo em 51% dos casos o osso, seguido de 17% para o pulmão, 16% para o cérebro e 6% para o fígado 7 . O câncer de mama é uma doença heterogênea, que pode ser dividida em subtipos distintos com base nos padrões de expressão de genes ou marcadores tumorais 8 . Para essa caracterização, realiza-se na avaliação por imuno-histoquímica a pesquisa de receptor de estrógeno (RE), receptor de progesterona (RP) e receptor de fator de crescimento epidermal humano (HER2) 2,8 .…”

Section: Introductionunclassified

Padrão de metástase no câncer de mama triplo negativo

Martins¹,

Rezende²,

Cordeiro³

et al. 2017

Rev. Bras. Mastol. (Impr.)

View full text Add to dashboard Cite

“…We know that age at diagnosis and ethnicity are associated with a specific tumor type and tumor behavior, which in turn are influenced by a woman's age at the first pregnancy [10,11]. This indicates that the global incidence of breast cancer changes over time in relation to geography, race and lifestyle changes, suggesting that breast cancer risk is influenced by a multiplicity of still undefined factors.…”

Section: Introductionmentioning

confidence: 99%

Prevention of Breast Cancer Could Be a Consequence of Pregnancy: A Review

Russo

2014

J Gen Pract

View full text Add to dashboard Cite

The genomic profile of parous women has shown that genes which are activated only within the first five years after pregnancy, may contribute to the increased risk of breast cancer in certain women. At the same time, pregnancy's protective effect is induced by a long-lasting genomic signature. This signature reveals that the differentiation process is centered around chromatin remodeling and represents a safeguard mechanism at genomic and post-transcriptional levels that maintains the fidelity of the transcription process, which could be the ultimate step mediating the protection of the breast conferred by full term pregnancy.

show abstract

Reproductive History and Oral Contraceptive Use in Relation to Risk of Triple-Negative Breast Cancer

Abstract: The association between parity and breast cancer risk differs appreciably for ER+ and triple-negative breast cancers. These findings require further confirmation because the biological mechanisms underlying these differences are uncertain.

Cited by 194 publications

References 33 publications

Heterogeneity of epidemiological factors by breast tumor subtypes in Korean women: A case-case study

Heterogeneity of epidemiological factors by breast tumor subtypes in Korean women: A case-case study

Padrão de metástase no câncer de mama triplo negativo

Prevention of Breast Cancer Could Be a Consequence of Pregnancy: A Review

Contact Info

Product

Resources

About