Reproductive factors, nutritional status and serum 25(OH)D levels in women with breast cancer: A case control study

Sofi, Nighat Yaseen; Jain, Monika; Kapil, Umesh; Seenu, Vuthaluru; Yadav, Chander Prakash; Pandey, Ravindra Mohan; Sareen, Neha

doi:10.1016/j.jsbmb.2017.11.003

Cited by 20 publications

(25 citation statements)

References 22 publications

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“…Another case control study in Asian women also suggests potential preventive effect of vitamin D on breast cancer for Korean women [57]. Similar findings of protective role of vitamin D against breast cancer are reported from studies in Indian populations [52,58]. Two studies done in Pakistan have only descriptive analysis in one [59] and small sample size in the other study [60].…”

Section: Introductionsupporting

confidence: 57%

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A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan

et al. 2020

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Background The prevalence of vitamin D inadequacy and breast cancer are both high among women living in Karachi, Pakistan. Methods A matched case control study was conducted in two hospitals of Karachi, Pakistan to evaluate the association of vitamin D (serum 25-hydroxyvitamin D) concentrations, vitamin D supplementation and sun exposure with breast cancer among Pakistani women. A total of 411 newly diagnosed histologically confirmed primary breast cancer cases were enrolled and 784 controls, free of breast and any other cancers, were matched by age (year of birth ± 5 years), residence in the same geographic area and study site. Information was collected on sociodemographic history, history of vitamin D supplementation, past medical and obstetrical history, family history of breast cancer, sun exposure history, histopathology reports and anthropometric measurement and venous blood was collected to measure serum 25-hydroxyvitamin D (25(OH)D) concentration. Results Compared to patients with sufficient serum vitamin D (>30 ng/ml), women with serum vitamin D deficiency (<20ng/ml), had a higher risk of breast cancer (OR = 1.65, 95%CI: 1.10, 2.50). Women with history of vitamin D supplementation one year prior to enrollment, had significant protective effect against breast cancer (OR = 0.32, 95% CI: 0.24, 0.43). Conclusions and recommendation Serum vitamin D deficiency was associated with increased risk of breast cancer, while vitamin D supplementation was associated with decreased risk of breast cancer.

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Section: Introductionsupporting

confidence: 57%

“…Studies in Asian population of breast cancer and the possible relationship with 25(OH)D concentrations, are limited [52][53][54]. A study from Jordon, although with limited number of women, did show an association of breast cancer with VDD [55].…”

Section: Introductionmentioning

confidence: 99%

A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan

et al. 2020

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“…Twenty-nine case control studies were analyzed to study the relationship between 25 (OH) D and breast cancer 10 , 19 – 22 , 25 , 27 , 29 – 35 , 38 , 42 , 44 – 46 , 48 , 49 , 51 , 55 , 56 , 58 – 63 obtaining a pooled OR of 0.65 (95%CI: 0.56–0.76) (Fig. 2a , Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

“…In both analyses, Egger test rejected the possibility of small study bias (p = 0.536 in case-control studies and p = 0.68 in cohort studies). On the other hand, five case-control studies 17 , 38 , 40 , 53 , 63 and three cohort studies 66 , 73 , 77 targeted premenopausal women; the pooled OR was 0.65 (95%CI: 0.52–0.82) for case-control studies and the RR for cohort studies was 1.01 (95% CI: 0.86–1.18) (Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

Vitamin D exposure and Risk of Breast Cancer: a meta-analysis

Estébanez

Gómez‐Acebo

Palazuelos

et al. 2018

Sci Rep

114

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The relationship between vitamin D and breast cancer is still controversial. The present meta-analysis examines the effects of the 25(OH)D, 1,25(OH)2D and vitamin D intake on breast cancer risk. For this purpose, a PubMed, Scopus and Web of Science-databases search was conducted including all papers published with the keywords “breast cancer” and “vitamin D” with at least one reported relative risk (RR) or odds ratio (OR). In total sixty eight studies published between 1998 and 2018 were analyzed. Information about type of study, hormonal receptors and menopausal status was retrieved. Pooled OR or RR were estimated by weighting individual OR/RR by the inverse of their variance Our study showed a protective effect between 25 (OH) D and breast cancer in both cohort studies (RR = 0.85, 95%CI:0.74–0.98) and case-control studies (OR = 0.65, 95%CI: 0.56–0.76). However, analyzing by menopausal status, the protective vitamin D – breast cancer association persisted only in the premenopausal group (OR = 0.67, 95%CI: 0.49–0.92) when restricting the analysis to nested case-control studies. No significant association was found for vitamin D intake or 1,25(OH)2D. Conclusion: This systematic review suggests a protective relationship between circulating vitamin D (measured as 25(OH) D) and breast cancer development in premenopausal women.

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“…25(OH)D düzeyi ile ilişki gösteren ve gösteremeyen; D vitamini alımına olumlu yanıt alan ve alamayan çalışmalar mevcuttur. Yakın zamanda yapılan bir çalışmada serum 25 (OH)D düzeyleri 20ng/mL'den düşük ve kalsiyum düzeyleri 10.5 mg/dl'den düşük olanlarda meme kanseri olma ihtimalinin yüksek olduğu gösterilmiştir 46. İki farklı kohort çalışmasında ise premenapozal dönemdeki kadınlarda yüksek doz D vitamini alımı ile meme kanseri gelişim riskinde istatistiksel olarak anlamlı azalma izlendiği gösterilmiş, ancak benzer koruyucu etki postmenapozal dönemdeki kadınlarda izlenmemiştir.…”

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Sekosteroit hormon olarak D vitamini ve kanser ilişkisi

Duman

Ün

2019

Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi

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Klasik olarak kalsiyum ve fosfat mekanizması üzerine olan etkilerinin yanı sıra antiproliferatif ve immünomodülatör gibi özellikleri de olan D vitamini aslında bir sekosteroit hormondur. Yakın dönemde yapılan çalışmalar, D vitamini eksikliğinin otoimmün ve kardiyovasküler hastalıkların yanı sıra kanser riskini de artırabildiğini göstermiştir. D vitamini eksikliği dünyada küresel bir salgın olarak bildirilmiştir. Buna ek olarak osteoporoz ve düşme kırıkları için de bir risk faktörü olarak tanımlanmıştır. Diyetle alınan ve deride güneş aracılığı ile sentezlenen D vitamininin, kandaki normal seviyelerinin sağlanması için doğru bilgi sahibi olmak çeşitli hastalıklardan ve kanserden korunmak açısından önemlidir. Bu nedenle öncelikle D vitaminin sentezi, kandaki düzeyleri, günlük ihtiyaç, metabolizması ve reseptörlerinin durumu derlendi. Buna ek olarak D vitamininin iyi bilinen kemik mineralizasyonu dışındaki etkilerinden olan özellikle kanser gelişimi ile olan ilişkisine dair güncel bilgiler derlendi.

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Reproductive factors, nutritional status and serum 25(OH)D levels in women with breast cancer: A case control study

Cited by 20 publications

References 22 publications

A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan

A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan

Vitamin D exposure and Risk of Breast Cancer: a meta-analysis

Sekosteroit hormon olarak D vitamini ve kanser ilişkisi

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