Reproductive factors and oesophageal cancer in Chinese women: a case-control study

Chen, Zu-Hui; Shao, Jian Yong; Lin, Jinrong; Zhang, Xia; Chen, Qing

doi:10.1186/1471-230x-11-49

Cited by 7 publications

(10 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By pooling all available data, we reported that decreased risk of EC and EAC, but not ESCC, was associated with the breast‐feeding status. Additionally, other reproductive factors, including parity and age at first birth, did not seem to confer modifying effects on the susceptibility to EC, unlike findings in independent studies . Moreover, other reproductive factors, such as number of children, history of pregnancy, and years between first and last birth, seemed to exert diverse effects on the development of EC in different populations .…”

Section: Discussioncontrasting

confidence: 63%

“…After a comprehensive search in databases of PubMed and Embase from their inception up to October 10, 2014, a total of 11 publications were retrieved . Characteristics of all included studies were summarized in Table .…”

Section: Resultsmentioning

confidence: 99%

“…Characteristics of all included studies were summarized in Table . Among the 11 articles, five were respectively divided into two independent studies according to histological types of EC . Accordingly, there were 16 independent studies included into the present meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Hormonal and reproductive factors and risk of esophageal cancer in women: a meta-analysis

Wang¹,

Zhang²,

Yan³

et al. 2015

Dis Esophagus

View full text Add to dashboard Cite

Currently published studies on the relationship between hormonal and reproductive factors and esophageal cancer (EC) risk in women have yielded contradictory findings. For a better understanding of this relationship, we first performed this meta-analysis by pooling all available publications. Sixteen independent studies were retrieved after a comprehensive search in PubMed and Embase databases. The pooled relative risks (RRs) with 95% confidence intervals (95% CIs) were calculated. The pooled RRs implicated that hormone replacement therapy was negatively associated with the risk of EC (RR = 0.72, 95% CI 0.60-0.86, P < 0.001) and esophageal squamous cell carcinoma (RR = 0.68, 95% CI 0.48-0.97, P = 0.031). Menopausal women were at an increased risk of EC (RR = 1.47, 95% CI 1.07-2.03, P = 0.018), particularly esophageal squamous cell carcinoma (RR = 1.66, 95% CI 1.12-2.48, P = 0.012). Additionally, decreased risk of EC (RR = 0.79, 95% CI 0.68-0.92, P = 0.003) and esophageal adenocarcinoma (RR = 0.66, 95% CI 0.53-0.82, P < 0.001) was demonstrated among women with breast-feeding history. Moreover, such associations were more significant among Caucasians, but not Asians. Our study suggests that menopause is an independent risk factor for EC, while hormone replacement therapy and breast-feeding history play a protective role against EC, particularly among Caucasians. All results are consistent with the hypothesis that effects of estrogen may lower the risk of EC in women.

show abstract

Section: Discussioncontrasting

confidence: 63%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Hormonal and reproductive factors and risk of esophageal cancer in women: a meta-analysis

Wang¹,

Zhang²,

Yan³

et al. 2015

Dis Esophagus

View full text Add to dashboard Cite

show abstract

“…However, the evidence for the association is still inconclusive, because the number of these studies is limited, many of the studies had a small number of female ESCC cases, and there are a few studies that did not show such associations [13, 14]. Therefore, further investigations are warranted.…”

Section: Introductionmentioning

confidence: 99%

Reproductive factors and risk of esophageal squamous cell carcinoma in northern Iran

Islami¹,

Cao²,

Kamangar³

et al. 2013

European Journal of Cancer Prevention

View full text Add to dashboard Cite

Background Several epidemiologic studies have suggested an inverse association between female reproductive factors and risk of esophageal squamous cell carcinoma (ESCC), but the evidence is not conclusive. We investigated the association of the number of pregnancies, live-births, and miscarriages/stillbirths in women and the association of the number of children in both sexes with ESCC risk in Golestan Province, a high-risk area in Iran. Methods Data from 297 histopathologically confirmed ESCC cases (149 women) and 568 controls (290 women) individually matched to cases for age, sex, and neighborhood of residence were included in this analysis. Conditional logistic regression was used to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Results The average numbers of live-births and miscarriages/stillbirths among controls were 8.2 and 0.8, respectively. Women with 6 or more live-births were at approximately one-third the risk of ESCC as those with 0–3 live-births; the OR (95% CI) for having 6–7 live-births was 0.33 (0.12–0.92). In contrast, the number of miscarriages/stillbirths was associated with an increase in ESCC risk. The OR (95% CI) for ≥ 3 versus no miscarriages/stillbirths was 4.43 (2.11–9.33). The number of children in women was suggestive an inverse association with ESCC, but this association was not statistically significant; in men, no association was seen. Conclusion The findings of this study support a protective influence of female hormonal factors on ESCC risk. However, further epidemiological and mechanistic studies are needed to prove a protective association.

show abstract

“…After a literature search and screening, a total of 14 studies were included in the final analysis (La Vecchia et al, 1993;Cheng et al, 2000;Gallus et al, 2001;Anderson et al, 2007;Corley et al, 2008;Whiteman et al, 2008;Freedman et al, 2010;Bodelon et al, 2011;Chen et al, 2011;Yu et al, 2011;Islami et al, 2013;Lu and Lagergren, 2012;Green et al, 2012aGreen et al, , 2012b. The selection process for the studies included in the metaanalysis is presented in Fig.…”

Section: Description Of Studiesmentioning

confidence: 99%

Reproductive factors are associated with oesophageal cancer risk: results from a meta-analysis of observational studies

Zhu

Yue

Yuan

et al. 2017

European Journal of Cancer Prevention

View full text Add to dashboard Cite

To further evaluate the association between reproductive events and the development of oesophageal cancer, we searched relevant studies using electronic databases (PubMed, ISI Web of Science). Study-specific relative risks with corresponding 95% confidence intervals (CI) in all analyses were used and multiple summary relative risk (SRR) estimates were calculated. We carried out subgroup analyses and used meta-regression techniques to explore potential sources of heterogeneity. Sensitivity analysis was carried out to identify whether pooled results were influenced by individual studies and publication bias was assessed by Begg's funnel plots and the Egger regression asymmetry test. Fourteen studies were eligible for inclusion in the meta-analysis, summarizing a total of 3816 oesophageal cancer cases. We found that age at menopause (SRR=0.70; 95% CI: 0.51-0.95) and hormone replacement therapy (SRR=0.67; 95% CI: 0.56-0.81) had an association with a decreased risk of oesophageal cancer. A similar result was obtained for parity (SRR=0.79; 95% CI: 0.71-0.89) and ever breastfeeding (SRR=0.65; 95% CI: 0.43-0.97). In contrast, postmenopausal status was associated with increased risk (SRR=1.65; 95% CI: 1.28-2.14). No statistically significant link was found with other exposures. Our meta-analysis supports the substantial influence of reproductive factors, which could be causally linked to oesophageal cancer.

show abstract

Reproductive factors and oesophageal cancer in Chinese women: a case-control study

Cited by 7 publications

References 14 publications

Hormonal and reproductive factors and risk of esophageal cancer in women: a meta-analysis

Hormonal and reproductive factors and risk of esophageal cancer in women: a meta-analysis

Reproductive factors and risk of esophageal squamous cell carcinoma in northern Iran

Reproductive factors are associated with oesophageal cancer risk: results from a meta-analysis of observational studies

Contact Info

Product

Resources

About