Reproductive factors and hormone use and risk of adult gliomas

Felini, Martha; Olshan, Andrew F.; Schroeder, Jane C.; Carozza, Susan E.; Miike, Rei; Rice, Terri; Wrensch, Margaret

doi:10.1007/s10552-008-9220-z

Cited by 45 publications

(88 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Details of subject ascertainment through the San Francisco regional populationbased registry's rapid case ascertainment program or the UCSF Neuro-oncology Clinic have been previously described. [50][51][52][53] Pertinent data for this analysis included age at histological diagnosis, gender, vital status, and survival time between diagnosis date and date of death for those deceased or between diagnosis date and date of last contact for those alive as well as cigarette smoking history and exposure to steroids, chemotherapy and/ or radiation therapy.…”

Section: Methodsmentioning

confidence: 99%

Epigenetic biomarkers of T-cells in human glioma

et al. 2012

Self Cite

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Epigenetic biomarkers of T-cells in human glioma

et al. 2012

Self Cite

View full text Add to dashboard Cite

“…Overall, these studies have yielded weak and inconsistent results. The most consistent finding to date has been a positive association between a relatively late age at menarche and increased risk of glioma observed in two cohort studies (18,24) and four case-control studies (11,16,17,22). Findings concerning other reproductive factors, including age at first birth, parity, and menopausal status, have not been consistent.…”

Section: Analytic Epidemiologymentioning

confidence: 97%

“…A number of epidemiologic studies (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24), most of which have used a case-control design (10-12, 14-17, 19, 21, 22), have examined menstrual and reproductive factors and the use of exogenous hormones in relation to risk of glioma in women (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Overall, these studies have yielded weak and inconsistent results.…”

Section: Analytic Epidemiologymentioning

confidence: 99%

“…Three studies (17,22,24) found that women who had ever used oral contraceptives were at decreased risk, but there were no clear trends with duration of use, and the remaining studies provided no evidence of an association (16,(18)(19)(20). Several studies (16,17,22) reported that ever users of menopausal hormone therapy had reduced risk of glioma, but there was no trend with duration of use, and other studies (18,19,23,24) showed no association of ever use of hormone therapy or duration of use with glioma risk. In a recent report, we found no association with ever use of hormone therapy, duration of use, or with ever use or duration of use of estrogen or progestin (24).…”

Section: Analytic Epidemiologymentioning

confidence: 99%

See 1 more Smart Citation

Do Steroid Hormones Play a Role in the Etiology of Glioma?

Kabat

Etgen

Rohan

2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Gliomas are the most common type of primary malignant brain tumor and have a very poor prognosis. Little is known, however, about the etiology of these tumors. Evidence from a number of sources suggests that endogenous steroid hormones may play a role in the development of gliomas. First, the descriptive epidemiology of glioma suggests a relative protection of females compared with males, particularly during the premenopausal years. Second, some gliomas and glioblastomas express estrogen receptors (ER), especially ERβ, as well as aromatase, the enzyme responsible for the conversion of testosterone to estradiol, and possibly other steroid hormone receptors. Third, experimental studies indicate that glioblastomas transplanted into animals grow at a slower rate in females compared with males. Finally, experimental studies show that estradiol, 2-methoxyestradiol, and a number of selective estrogen receptor modulators inhibit proliferation of gliomas and induce cell death. These hormonal agonists and antagonists may act either through classical steroid hormone receptors or independently of such receptors. In view of these findings, further clinical, experimental, and epidemiologic studies are needed to elucidate the role of steroid hormone agonists and antagonists in the development and proliferation of glioma. If hormonal pathways are involved in gliomagenesis, this could eventually lead to the design of preventive strategies. Cancer Epidemiol Biomarkers Prev; 19(10); 2421-7. ©2010 AACR.Little is known about the etiology of brain neoplasms, which in general are highly fatal (1). Gliomas, which include astrocytomas, oligodendrogliomas, and ependymomas, are the most common type of primary malignant brain tumor, accounting for approximately 80% of cases (2). Gliomas originate from glial cells (astrocytes or oligodendrocytes). Gliobastoma multiforme, the highest grade of glioma, is the most common and most aggressive type of malignant glioma. Most cases of glioblastoma multiforme (∼90%), referred to as "primary glioblastoma multiforme," develop rapidly without detectable evidence of a less malignant precursor tumor, whereas about 10% of glioblastomas, referred to as "secondary glioblastoma multiforme," develop slowly from low-grade astrocytomas (3). The only established risk factors for gliomas are high-dose ionizing radiation and certain rare genetic conditions, which together account for only a small proportion of cases (1, 4, 5). However, evidence from a number of sources suggests a possible role of endogenous ovarian steroid hormones in the development of glioma. Given that this topic has received little attention in major reviews on brain tumor epidemiology to date (1, 4-6), we review here findings from descriptive and analytic epidemiology, clinical studies, and experimental animal and cell culture studies pertinent to the potential role of steroid hormones in the development of glioma. Descriptive EpidemiologyThe incidence rate of glioma in adulthood is 50% greater in men than in women (5, 7). For example...

show abstract

“…This step excluded articles about children, other types of brain tumors, trophoblastic tumors, and articles on treatment options. Eighteen of the 47 articles reported epidemiological studies about the role of hormones in the occurrence of gliomas and meningiomas [38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55], while the others did not deal with the hormonal hypothesis or were experimental. Three additional articles [56][57][58] were identified from the references of the 18 above-mentioned articles.…”

Section: Article Selectionmentioning

confidence: 99%