Reproductive experiences of women who cryopreserved oocytes for non-medical reasons

Hammarberg, Karin; Kirkman, Maggie; Pritchard, Natasha; Hickey, Martha; Peate, Michelle; McBain, John; Agresta, Franca; Bayly, Christine; Fisher, Jane

doi:10.1093/humrep/dew342

Cited by 63 publications

(87 citation statements)

References 32 publications

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“…Despite recommendations, the mean age of women who choose to bank their eggs is high, both internationally and in our report. In a Spanish setting, the mean age at vitrification was 37.7 years, and corresponding data for Australia were 37.1 years . These results are similar to those of the present study with a mean age at vitrification of 36.9 years.…”

Section: Discussionsupporting

confidence: 90%

“…In our material, 15% of the women returned for autologous IVF. In a recent Spanish study, the usage was around 9% during a similar time span, and in a follow up in Australia by Hammarberg et al, only 6 women (6%) had used their stored oocytes, of whom 3 had given birth . Given that the majority of oocytes will never be used, it can be questioned whether elective egg freezing is cost‐effective.…”

Section: Discussionmentioning

confidence: 97%

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Elective oocyte freezing for nonmedical reasons: a 6‐year report on utilization and in vitro fertilization results from a Swedish center

Wennberg

Schildauer

Brännström

2019

Acta Obstet Gynecol Scand

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Introduction Elective oocyte freezing started in Sweden in 2011, a few years after oocyte vitrification was introduced internationally as an effective method for cryopreservation of oocytes. The objective of this study is to describe the age of the women who choose to undergo this procedure, the subsequent utilization of cryopreserved oocytes and the results of autologous in vitro fertilization (IVF). Material and methods We conducted a descriptive follow‐up study of a subset of women at a private IVF center. All women (n = 254) who electively vitrified oocytes at Nordic IVF Göteborg between 1 August 2011 and 31 August 2017 were included. Ages at oocyte vitrification and warming, number of vitrified oocytes and results of IVF are presented. Results A total of 254 women underwent elective oocyte freezing and 38 (15%) of these returned to use their cryopreserved oocytes for autologous IVF before November 2018. In the total cohort, the mean number of vitrified oocytes per woman, undergoing one or more oocyte retrievals, was 7.6 (range 1‐37). Their mean age at first vitrification was 36.9 years (range 23‐43 years). The mean ages for the subset of women that subsequently used their oocytes for IVF were 38.7 and 42.7 years at vitrification and oocyte warming, respectively. Forty‐nine oocyte warming cycles resulting in 42 fresh and 16 frozen embryo transfers, have been performed. Cumulative live birth rate/ongoing pregnancy rates are 63%, 26% and 0% in women of ages 36‐37, 38‐39 and ≥40 years of age at vitrification, respectively. Five babies have been born and there are 5 ongoing pregnancies. Conclusions Elective oocyte freezing has been offered in Sweden for >7 years. The utilization rate has so far been low. Pregnancy results after oocyte warming and IVF are encouraging when oocytes are cryopreserved at an age below 40 years.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Elective oocyte freezing for nonmedical reasons: a 6‐year report on utilization and in vitro fertilization results from a Swedish center

Wennberg

Schildauer

Brännström

2019

Acta Obstet Gynecol Scand

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“…For women who face an immediate loss of fertility, the choice to undertake this procedure is understandable. However, there is now rising interest in using OC as a way to delay childbirth in healthy women [16].…”

Section: Preservation Of Fertilitymentioning

confidence: 99%

“…Despite this, many recently surveyed women are in support of using oocyte cryopreservation as a means for extending fertility, but this openness towards the procedure has yet to translate into data [19]. A recent survey of 96 healthy Australian women who had opted for OC indicated that only 6 returned for the oocytes; of those, only half succeeded in giving birth [16]. The mean age for this cohort, however, was 37 years for oocyte freezing, which is past the point of peak fertility, and the small sample size makes this study only minimally effective at demonstrating the potential of OC for young, healthy women hoping to extend their fertility.…”

Section: Preservation Of Fertilitymentioning

confidence: 99%

“…The mean age for this cohort, however, was 37 years for oocyte freezing, which is past the point of peak fertility, and the small sample size makes this study only minimally effective at demonstrating the potential of OC for young, healthy women hoping to extend their fertility. Despite this, the study is one of the few that assess the efficacy of non-medical OC [16].…”

Section: Preservation Of Fertilitymentioning

confidence: 99%

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Freezing eggs to get ahead: a look at oocyte cryopreservation for non-medical reasons

Zhang

2017

UOJM

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RÉSUMÉ L'âge des premières grossesses chez les femmes a augmenté, en partie à cause de la hiérarchisation du développement de carrière. Le vieillissement maternel est un facteur important affectant la fertilité, et est corrélé avec l'infertilité et plusieurs résultats défavo-rables de la grossesse. La cryoconservation des ovocytes (CO), recommandée aux patients cancéreux en attendant les traitements affectant la fertilité, est actuellement explorée comme une option pour augmenter la fertilité féminine en raison de son efficacité dans la fécondation in vitro (FIV). Cependant, il y a un manque de données confirmant la supériorité de la procédure sur la grossesse naturelle chez les femmes en bonne santé, étant donné les complications potentielles. La prudence dans la recommandation de la procédure devrait donc être prise.

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Reproductive outcomes from ten years of elective oocyte cryopreservation

Kasaven

Jones

Heath

et al. 2022

Arch Gynecol Obstet

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Research question To assess the relationship between the number of oocytes retrieved during elective oocyte cryopreservation (EOC) cycles with various clinical, biochemical, and radiological markers, including age, body mass index (BMI), baseline anti-Müllerian hormone (AMH), antral follicle count (AFC), Oestradiol level (E2) and total number of follicles ≥ 12 mm on the day of trigger. To also report the reproductive outcomes from women who underwent EOC. Methods A retrospective cohort of 373 women embarking on EOC and autologous oocyte thaw cycles between 2008 and 2018 from a single London clinic in the United Kingdom. Results 483 stimulation cycles were undertaken amongst 373 women. The median (range) age at cryopreservation was 38 (26–47) years old. The median numbers of oocytes retrieved per cycle was 8 (0–37) and the median total oocytes cryopreserved per woman was 8 (0–45). BMI, E2 level and number of follicles ≥ 12 mm at trigger were all significant predictors of oocyte yield. Multivariate analysis confirmed there was no significant relationship between AFC or AMH, whilst on univariate analysis statistical significance was proven. Thirty six women returned to use their cryopreserved oocytes, of which there were 41 autologous oocyte thaw cycles undertaken. There were 12 successful livebirths achieved by 11 women. The overall livebirth rate was 26.8% per cycle. No livebirths were achieved in women who underwent EOC ≥ 40 years old, and 82% of all livebirths were achieved in women who had done so between 36 and 39 years old. Conclusion Clinical, biochemical and radiological markers can predict oocyte yield in EOC cycles. Reproductive outcomes are more favourable when cryopreservation is performed before the age of 36, with lower success rates of livebirth observed in women aged 40 years and above.

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Reproductive experiences of women who cryopreserved oocytes for non-medical reasons

Abstract: Not applicable.

Cited by 63 publications

References 32 publications

Elective oocyte freezing for nonmedical reasons: a 6‐year report on utilization and in vitro fertilization results from a Swedish center

Elective oocyte freezing for nonmedical reasons: a 6‐year report on utilization and in vitro fertilization results from a Swedish center

Freezing eggs to get ahead: a look at oocyte cryopreservation for non-medical reasons

Reproductive outcomes from ten years of elective oocyte cryopreservation

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