Reproductive experience modulates dopamine-related behavioral responses

Modulation of post-coital dopaminergic tone by prior parity

“…1 B and D, respectively). These data confirmed and expanded the notion that the reproductive experience modulated the dopaminergic tone (Bridges et al, 1993;Felicio et al, 1996;Bridges et al, 1997;Hucke et al, 1998Hucke et al, , 2001Byrnes et al, 2001;Sider et al, 2003;. A similar effect was observed in DA response to haloperidol, although the drug was not supposed to produce an increase in DA levels (P<0.05; Fig.…”

“…Dopamine-related behavioral responses are also affected by the reproductive experience, and these phenomena vary according to brain region. Apomorphine-induced stereotypy is significantly higher in primiparous compared to nulliparous rats (Byrnes et al, 2001;Hucke et al, 2001), while apomorphine-induced hypothermia does not differ between the groups, suggesting that the sensitivity of dopaminergic terminals in striatum are affected, while the sensitivity of hypothalamic terminals may not be modulated by the reproductive experience (Hucke et al, 2001). Studies with prepulse inhibition also demonstrate that forebrain dopamine receptors are more sensitive in the females that have experienced pregnancy and lactation as compared to virgin females (Byrnes et al 2001;.…”

“…Studies with prepulse inhibition also demonstrate that forebrain dopamine receptors are more sensitive in the females that have experienced pregnancy and lactation as compared to virgin females (Byrnes et al 2001;. Pre-synaptic mechanisms seem not to be altered as a function of reproductive experience, as suggested by the failure to demonstrate any reproductive experience-induced differences in the stereotypic behavior responses induced by the indirect dopamine agonist amphetamine (Hucke et al, 2001). In addition to the previously mentioned drugs, dopamine is also involved in the mechanisms of action of toxic plants (Schwarz et al, 2005 and.…”

Reproductive experience influences grooming behavior during pregnancy in rats

“…Dopaminemediated behaviors are also modulated by reproductive experience (17,18). Since dopaminergic systems play a role in grooming behavior (19,20) and dopaminergic function is modulated by this same experience (9,18), the reproductive experience-induced increase in pregnant rat self-licking described here may be related to changes in dopaminergic function. The present results may reflect reproductive experience-induced changes in processes involving neurotransmission and/ or neuromodulation.…”

Desenvolvimento de um método de microlavagem para estudo do microambiente uterino em bovinos: efeitos na função luteínica, crescimento folicular e manutenção da prenhez inicial

“…A técnica de microdiálise foi inicialmente desenvolvida por Ungerstedt (1971) e amplamente utilizada para estudos no sistema nervoso central (HUCKE et al, 2001;HUCKE et al, 1998;KENDRICK et al, 1988). A microdiálise foi utilizada para estudos das secreções de estruturas ovarianas de vacas (SHAW, 1995) e uterinas de mulheres (LICHT et al, 2001).…”