Reproductive effects of oestrogenic endocrine disrupting chemicals in Astyanax rivularis inhabiting headwaters of the Velhas River, Brazil

Weber, André Alberto; Moreira, Davidson Peruci; Melo, Rafael Magno Costa; Vieira, Augusto Bicalho Cruz; Prado, Paula Suzanna; Silva, Mirra Angelina Neres da; Bazzoli, Nilo; Rizzo, Elizete

doi:10.1016/j.scitotenv.2017.02.181

Cited by 30 publications

(5 citation statements)

References 48 publications

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“…Inam, Nwoke, Udosen and Offiong (2019) detected <0.20 to 2.15 μg/L of 4‐NP in surface water in the New Calabar river, Nigeria. Weber et al (2017) detected 0.067‐0.64 μg/L of 4‐NP in the headwaters of Velhas River in Brazil. Song, Nagae, Takao and Soyano (2020) detected 0.037 and 1.10 μg/L of 4‐NP in the Taria river and Yokojyukken river, respectively, in Japan.…”

Section: Discussionmentioning

confidence: 99%

Exposure to 4‐nonylphenol induces a shift in the gene expression of gsdf and testis‐ova formation and sex reversal in Japanese medaka (Oryzias latipes)

Horie

Kanazawa

Takahashi

et al. 2020

J of Applied Toxicology

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The branched isomer mixture 4‐nonylphenol (4‐NP) has been used worldwide as a surfactant, and can have endocrine‐disrupting effects on aquatic organisms. For instance, 4‐NP induces the formation of testis‐ova (i.e., testicular and ovarian tissue in the same gonad) or male to female sex reversal of various teleost fishes. Recently, our group revealed that altered gsdf gene expression is associated with disruption of gonadal differentiation in Japanese medaka (Oryzias latipes) embryos exposed to methyltestosterone or bisphenol A, suggesting that gsdf might be useful as a biomarker for predicting the impact of endocrine‐disrupting chemicals (EDCs) on gonadal differentiation. Here, we used 4‐NP to examine further whether gsdf expression at the embryo stage is useful for predicting EDC impact on gonadal sex differentiation. When fertilized medaka eggs were exposed to 32 or 100 μg/L 4‐NP, testis‐ova in genetic males and sex reversal from genetic male to phenotypic female were observed. At stage 38 (just before hatching), 4‐NP exposure at 1‐100 μg/L did not affect gsdf expression in XX embryos compared with the nontreated control; however, in XY embryos, the gsdf expression in the 100 μg/L‐exposed group was significantly lower than that in the controls. The 4‐NP concentration at which gsdf expression was suppressed was equal to that at which testis‐ova and sex reversal were induced. These results indicate that expression of the gsdf gene at the embryonic stage in medaka is a useful biomarker for predicting the impact of EDCs on sexual differentiation.

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Section: Discussionmentioning

confidence: 99%

Exposure to 4‐nonylphenol induces a shift in the gene expression of gsdf and testis‐ova formation and sex reversal in Japanese medaka (Oryzias latipes)

Horie

Kanazawa

Takahashi

et al. 2020

J of Applied Toxicology

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“…Although they are small fish, the lambaris have ecological and commercial importance, since they are forage species for several predators 27 and are caught in professional and artisanal fishing, possibly constituting protein source for riverine populations 24 . In addition, Astyanax species have been indicated as sentinels for environmental investigations of pollutants 28,29 .…”

Section: Introductionmentioning

confidence: 99%

Integrative approach detects natural hybridization of sympatric lambaris species and emergence of infertile hybrids

Pinheiro

Melo

Teixeira

et al. 2019

Sci Rep

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Despite its relevance for ecology, evolution and conservation of species, natural hybridization and hybrids biology are still poorly studied in freshwater fish. Here, we tested the hypothesis that sympatric species Astyanax paranae and A. fasciatus are able to interbreed in the natural environment and presented evidence for the first record of hybridization between these species. We analyzed anatomical traits, gametogenesis, reproductive biology, and genetic variations of the COI and S7 genes of both species and putative hybrids. Intermediate morphometric and meristic features were observed in hybrids when compared to A. paranae and A. fasciatus. Overlap in reproductive season was showed for these species, with greater reproductive activity from August to January, but hybrids did not present any sign of gonadal maturation. Oogonia and perinucleolar follicles as well as spermatogonia and primary spermatocytes were found in hybrids, but previtellogenic and vitellogenic follicles, spermatids, and spermatozoa were absent. Moreover, several alterations in gametogenesis were detected, such as interrupted meiosis in both males and females, vacuolated and degenerated germ cells, increased interstitial tissue, and presence of immune cells. Molecular analyses supported the hypothesis of hybridization between A. paranae and A. fasciatus. Overall, our multidisciplinary approach also provides strong evidence that hybrids are infertile.

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“…The highest part of the basin is a region of springs, located southeast of the so-called Iron Quadrangle (IQ), where the intense mining activity generates effluents with high contents of suspended solids and various metal species. 1,2 The IQ region has been mined since the mid-seventeenth century, with historical release of metals into the watercourses that drain the region. 3 In the River Basin, arsenic (As) has been found in surface waters at concentrations exceeding the established limits for water destined for human consumption.…”

Section: Introductionmentioning

confidence: 99%

Arsenic and Trace Metals in Water and Sediment of the Velhas River, Southeastern Iron Quadrangle Region, Minas Gerais, Brazil

Silva¹,

Bellato²,

Neto³

et al. 2018

Quim. Nova

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River provides the public water supply for much of this region. The gold and iron mining activities in the Velhas River yield considerable amounts of suspended solids as well as metals to the hydrological system of the region. Thus, the present study sought to evaluate the concentrations of arsenic and trace metals in the waters and their distribution and mobility in sediment by BCR sequential extraction. Arsenic concentrations in the water samples were between 78.1 and 85.3 μg L-1 , which exceeded 10 μg L-1 (maximum limit permitted by Brazilian environmental regulations for water destined to human consumption, CONAMA Resolution 357/2005). The sequential extraction of the sediment showed considerable amounts of As (20%), Cd (55%), Co (56%), Cr (16%), Cu (23%), Ni (29%), Pb (47%) and Zn (71%) associated with the geochemical fractions considered potentially available for the remobilization to the aquatic environment. The presence of the elements in these fractions indicated high ecotoxicological risk and potential harm to the health of the local population.

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Reproductive effects of oestrogenic endocrine disrupting chemicals in Astyanax rivularis inhabiting headwaters of the Velhas River, Brazil

Cited by 30 publications

References 48 publications

Exposure to 4‐nonylphenol induces a shift in the gene expression of gsdf and testis‐ova formation and sex reversal in Japanese medaka (Oryzias latipes)

Exposure to 4‐nonylphenol induces a shift in the gene expression of gsdf and testis‐ova formation and sex reversal in Japanese medaka (Oryzias latipes)

Integrative approach detects natural hybridization of sympatric lambaris species and emergence of infertile hybrids

Arsenic and Trace Metals in Water and Sediment of the Velhas River, Southeastern Iron Quadrangle Region, Minas Gerais, Brazil

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