Reproductive effects of occupational DDT exposure among male malaria control workers.

Salazar-García, F.; Gallardo-Díaz, Esperanza; Cerón-Mireles, Prudencia; Loomis, Dana; Borja-Aburto, Víctor Hugo

doi:10.1289/ehp.112-1241918

Cited by 21 publications

(13 citation statements)

References 36 publications

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“…Maternal and paternal environmental exposure (Crisostomo and Molina, 2002; Garry et al., 1996; Kristensen et al, 1997) as well as maternal (Kristensen et al, 1997) and paternal occupational exposure (Dimich-Ward et al, 1996; El-Helaly et al., 2011; Salazar-Garcia et al, 2004), residence in areas with high pesticide use (Garry et al, 1996; Garry et al, 2002; Shaw et al, 1999), and spring conception (Garry et al, 1996) emerged as risk factors. Nevertheless, other studies challenge these results.…”

Section: Pesticides and Development Of Congenital Abnormalitiesmentioning

confidence: 99%

Association of pesticide exposure with human congenital abnormalities

Kalliora

Mamoulakis

Vasilopoulos

et al. 2018

Toxicology and Applied Pharmacology

102

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Human pesticide exposure can occur both occupationally and environmentally during manufacture and after the application of indoor and outdoor pesticides, as well as through consumption via residues in food and water. There is evidence from experimental studies that numerous pesticides, either in isolation or in combination, act as endocrine disruptors, neurodevelopmental toxicants, immunotoxicants, and carcinogens. We reviewed the international literature on this subject for the years between 1990 and 2017. The studies were considered in this review through MEDLINE and WHO resources. Out of the n = 1817 studies identified, n = 94 were reviewed because they fulfilled criteria of validity and addressed associations of interest. Epidemiological studies have provided limited evidence linking pre- and post-natal exposure to pesticides with cancers in childhood, neurological deficits, fetal death, intrauterine growth restriction, preterm birth, and congenital abnormalities (CAs). In this review, the potential association between pesticide exposure and the appearance of some human CAs (including among others musculoskeletal abnormalities; neural tube defects; urogenital and cardiovascular abnormalities) was investigated. A trend towards a positive association between environmental or occupational exposure to some pesticides and some CAs was detected, but this association remains to be substantiated. Main limitations of the review include inadequate exposure assessment and limited sample size. Adequately powered studies with precise exposure assessments such as biomonitoring, are warranted to clarify with certainty the potential association between pesticide exposure and human CAs.

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Section: Pesticides and Development Of Congenital Abnormalitiesmentioning

confidence: 99%

Association of pesticide exposure with human congenital abnormalities

Kalliora

Mamoulakis

Vasilopoulos

et al. 2018

Toxicology and Applied Pharmacology

102

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“…Animal studies with p,p ′-DDE show a number of reproductive abnormalities in male offspring (Gray et al 2001); whether similar effects are seen in humans at usual exposure levels is uncertain (Flores-Luévano et al 2003; Hosie et al 2000; Longnecker et al 2002). Paternal occupational DDT exposure has also been associated with birth defects (Salazar-García et al 2004). …”

mentioning

confidence: 99%

Prenatal DDT Exposure in Relation to Anthropometric and Pubertal Measures in Adolescent Males

Gladen

Klebanoff

Hediger

et al. 2004

Environ Health Perspect

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DDT (dichlorodiphenyltrichloroethane), a pesticide once used widely in agriculture and now limited to public health use, remains a controversial chemical because of a combination of benefits and risks. DDT or its breakdown products are ubiquitous in the environment and in humans. Compounds in the DDT family have endocrine actions and have been associated with reproductive toxicity. A previous study reported associations between prenatal exposure to p,p′-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene] and increased height and weight in adolescent boys. We examined a group with higher exposures to see whether similar associations would occur. Our study group was 304 males born in Philadelphia in the early 1960s who had participated in a previous study. Anthropometric and pubertal measures from one to six visits during their adolescent years were available, as were stored maternal serum samples from pregnancy. We measured p,p′-DDE, p,p′-DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane], and o,p′-DDT [1,1,1-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-ethane] in the maternal serum. Outcomes examined in the boys were height, ratio of sitting height to height, body mass index, triceps skinfold thickness, ratio of subscapular to the sum of triceps and subscapular skinfold thicknesses, skeletal age, serum testosterone, and serum dehydroepiandrosterone sulfate. No associations between prenatal exposure to any of the DDT compounds and any outcome measure were seen.

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“…DDT may act as a carcinogen (Eskenazi et al , 2009), and has, in high levels, been linked to low semen volume and impaired sperm motion (Eskenazi et al , 2009). Further, paternal exposure has been linked to birth defects (Salazar-Garcia et al , 2004). However, exposure to DDT also occurred outside of the camps and was extremely high (Westin, 1993).…”

Section: Discussionmentioning

confidence: 99%

Live birth sex ratios and father's geographic origins in Jerusalem, 1964–1976

Groeger

Opler

Kleinhaus

et al. 2016

American J Hum Biol

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Objective To examine whether ancestry influenced sex ratios of offspring in a birth cohort before parental antenatal sex selection influenced offspring sex. Methods We measured the sex ratio as the percent of males according to countries of birth of paternal and maternal grandfathers in 91,459 live births from 1964 to 1976 in the Jerusalem Perinatal Study. Confidence limits (CI) were computed based on an expected sex ratio of 1.05, which is 51.4% male. Results Of all live births recorded, 51.4% were male. Relative to Jewish ancestry (51.4% males), significantly more males (1,761) were born to Muslim ancestry (54.5, 95% CI=52.1–56.8, p=.01). Among the former, sex ratios were not significantly associated with paternal or maternal age, education, or offspring’s birth order. Consistent with a preference for male offspring, the sex ratio decreased despite increasing numbers of births over the 13-year period. Sex ratios were not affected by maternal or paternal origins in North Africa or Europe. However, the offspring whose paternal grandfathers were born in Western Asia included fewer males than expected (50.7, 50.1–51.3, p=.02), whether the father was born abroad (50.7) or in Israel (50.8). This was observed for descendents of paternal grandfathers born in Lebanon (47.6), Turkey (49.9), Yemen & Aden (50.2), Iraq (50.5), Afghanistan (50.5), Syria (50.6), and Cyprus (50.7); but not for those from India (51.5) or Iran (51.9). The West Asian group showed the strongest decline in sex ratios with increasing paternal family size. Conclusions A decreased sex ratio associated with ancestry in Western Asia is consistent with reduced ability to bear sons by a subset of Jewish men in the Jerusalem cohort. Lower sex ratios may be due to pregnancy stress, which may be higher in this subgroup. Alternatively, a degrading Y chromosome haplogroup or other genetic or epigenetic differences on male germ lines could affect birth ratios, such as differential exposure to an environmental agent, dietary differences, or stress. Differential stopping behaviors that favor additional pregnancies following the birth of a daughter might exacerbate these lower sex ratios.

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Reproductive effects of occupational DDT exposure among male malaria control workers.

Cited by 21 publications

References 36 publications

Association of pesticide exposure with human congenital abnormalities

Association of pesticide exposure with human congenital abnormalities

Prenatal DDT Exposure in Relation to Anthropometric and Pubertal Measures in Adolescent Males

Live birth sex ratios and father's geographic origins in Jerusalem, 1964–1976

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