Reproductive Effects of Hydromethanolic Leaf Extracts of Cnidoscolus aconitifolius (Euphorbiacea) in Streptozotocin Induced-diabetic Rats

Abstract

Introduction:The potency of plants is largely due to the presence of phytochemicals contain in them. Plant-derived chemicals influence endocrine activities in animals and humans have received affluent attention due to their possible adverse effects or benefits, especially on sex hormones. Aim: This study is aimed at evaluating the effect of hydromethanolic leaf extract of Cnidoscolus aconitifolius on sex hormones in streptozotocin induced-diabetic wistar rats. Materials and Methods: Thirty (30) wistar rats with an average weight of 230 grams, were randomly assigned into five groups of 6 (six) animals each. Group 1: served as negative control (non-diabetic) and received normal animal chow and water ad libitum, group 2: served as positive control group and received 10 mg/kg bw of glibenclamide, groups 3, 4 and 5 served as Original Research Article

Effect of Hydromethanolic Seed Extract of Garcinia Kola on Male Reproductive Hormones

“…According to Iyke et al (2018), FSH play vital roles in gonadal development, steroidogenesis and maturation at puberty as well as gamete production (spermatogenesis) during fertile life, while the LH is known to stimulate the secretion of sex steroids (Testosterone) from the gonads. As seen in this present study, the administration of the hydromethanol seed extract of G. kola caused a reduction in the level of the FSH and LH but increased the level of Testosterone, with a significant increase recorded in the 200 mg/kg group.…”