Reproductive effects in fathead minnows (Pimphales promelas) following a 21 d exposure to 17α-ethinylestradiol

Armstrong, Brandon M.; Lazorchak, James M.; Jensen, Kathleen; Haring, Herman J.; Smith, Mark E.; Flick, Robert W.; Bencic, David C.

doi:10.1016/j.chemosphere.2015.08.078

Cited by 44 publications

(28 citation statements)

References 35 publications

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“…, and differ few from the latter, it is possible to draw the conclusion that the model is appropriate enough to describe the adsorption process. This fi nding suggests that the ratelimiting step in the adsorption process may be chemisorptions involving valent forces through the sharing or exchanging of electrons between sorbent and sorbate [15].In conclusion, the second-order rate expression fi ts the data better than the fi rstorder-rate model. The intraparticle model is commonly used for identifying the adsorption mechanism.…”

Section: Preliminary Resultsmentioning

confidence: 90%

“…Concerning the wildlife, EE2 has been shown to cause adverse reproductive effects, such as increased synthesis and secretion of vitellogenin in male subjects or changes in gonad somatic index in female Pimephalespromelas [11,12]. More interesting are also the recent papers concerning the reproductive systems in zebra fi sh [13,14] and in Pimephalespromelas [15]. However the effects of synthetic steroids on fi sh reproduction are not limited to laboratory exposures.…”

Section: Introductionmentioning

confidence: 99%

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Removal of 17-α Ethinylestradiol from Water Systems by Adsorption on Polyacrylonitrile Beads: Isotherm and Kinetics Studies

Mita¹,

Forte²,

Rossi³

et al. 2018

Ann Environ Sci Toxicol

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An investigation on the removal of 17-a-Ethinyl Estradiol (EE2) from aqueous solutions using Polyacrylonitrile (PAN) beads has been carried out under closed conditions. The kinetic and equilibrium results obtained for EE sorption with different initial concentrations have been analyzed. Experimental data at equilibrium have been correlated with the Langmuir, Freundlich, Tempkin, and Dubinin-Radushkevich (D-R) isotherm models. The applicability of the isotherm equations to the adsorption system has been compared by means of the correlation coeffi cients. The adsorption data resulted fi tted well by the Freundlich isotherm model. Kinetic analysis was performed with three different types of kinetic adsorption models using the pseudo-fi rst-order, pseudo-second-order, and simple Elovich models. Analysis of the kinetic data indicated that the EE2 adsorption was a second-order process. Diffusion mechanisms have been analyzed by means of the diffusion rate equations inside particulate of Dumwald-Wagner and intraparticle models. The actual rate-controlling step involved in the EE sorption process was determined by further analysis of the sorption data by the kinetic expression given by Boyd. All together these results allowed to understand the adsorption mechanism of the process and have shown the usefulness in using PAN beads in removing EE2 from synthetic aqueous solutions, also at concentrations higher than those measured in the environment.

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Section: Preliminary Resultsmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Removal of 17-α Ethinylestradiol from Water Systems by Adsorption on Polyacrylonitrile Beads: Isotherm and Kinetics Studies

Mita¹,

Forte²,

Rossi³

et al. 2018

Ann Environ Sci Toxicol

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show abstract

“…Both doses of EE 2 had a disruptive effect on gilthead seabream reproduction as revealed by increased hepatic vtg gene expression and plasma Vtg and increased plasma E 2 and decreased plasma T, 11-KT and P compared to the control. Modifications in plasma E 2 , T and 11-KT in response to EE 2 exposure in fish 12,43,44 including the gilthead seabream, depends on the reproductive stage at which it occurs 7,8 . The effect of EE 2 on the testis histology depended on the dose and higher doses had a more pronounced effect in common with previous reports in the gilthead seabream 8,35 and other teleost fish 13,45 .…”

Section: Discussionmentioning

confidence: 99%

17α-ethynylestradiol prevents the natural male-to-female sex change in gilthead seabream (Sparus aurata L.)

Hernández

Cabas

Rodenas

et al. 2020

Sci Rep

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Exposure to 17α-ethynylestradiol (EE2, 5 μg/g food) impairs some reproductive events in the protandrous gilthead seabream and a short recovery period does not allow full recovery. In this study, spermiating seabream males in the second reproductive cycle (RC) were fed a diet containing 5 or 2.5 μg EE2/g food for 28 days and then a commercial diet without EE2 for the remaining RC. Individuals were sampled at the end of the EE2 treatment and then at the end of the RC and at the beginning of the third RC, 146 and 333 days after the cessation of treatment, respectively. Increased hepatic transcript levels of the gene coding for vitellogenin (vtg) and plasma levels of Vtg indicated both concentrations of EE2 caused endocrine disruption. Modifications in the histological organization of the testis, germ cell proliferation, plasma levels of the sex steroids and pituitary expression levels of the genes coding for the gonadotropin β-subunits, fshβ and lhβ were detected. The plasma levels of Vtg and most of the reproductive parameters were restored 146 days after treatments. However, although 50% of the control fish underwent sex reversal as expected at the third RC, male-to female sex change was prevented by both EE2 concentrations.

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“…[1][2][3][4][5] Some of these substances are referred to as endocrine disruptors since they have the capacity to alter the function of the endocrine system, interfering with the metabolism and causing reproductive disorders and increased breast cancer potential in different organisms. 6,7 The natural estrogens estrone (E1) and 17 -estradiol (E2) and the synthetic estrogen 17 -ethynylestradiol (EE2) are contaminants that may trigger a number of effects when in the environment, such as the feminization of fish, 8,9 early menopause in women 2 and increase in the incidence of cancer, 10 imposing a great risk to humans, soils, plants and water resources. 2 They have been included since 2015 in the monitoring list of substances of Directive 2008/105/EC of the European Parliament.…”

Section: Introductionmentioning

confidence: 99%

Application of a stable Ag/TiO₂ film in the simultaneous photodegradation of hormones

Lima

Emídio

Nogueira

et al. 2019

J of Chemical Tech & Biotech

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BACKGROUND The natural hormones estrone (E1) and 17β‐estradiol (E2) and the synthetic hormone 17α‐ethynylestradiol (EE2) are excreted daily by humans and may reach water and wastewater treatment plants, which do not efficiently remove these estrogens. The aim of the present study was to evaluate the efficiency and reusability of Ag/TiO2 films as catalysts for simultaneous degradation of the hormones E1, E2 and EE2 in aqueous medium by heterogeneous photocatalysis and the contribution of reactive oxygenated species. The influence of aeration on the system and the effects of estrogen concentration and Ag/TiO2 film area were also evaluated in the photodegradation process. RESULTS The photocatalytic degradation assays showed efficiency higher than 97% for E2 and EE2 (10 μg L−1) after approximately 3.5 h and above 95% for E1 (100 μg L−1) after 4.5 h. It was observed that hydroxyl radical is the main reactive oxidant species in the photodegradation process, responsible for 87, 86 and 79% degradation of E1, E2 and EE2 respectively. CONCLUSION The treatment process applied using the Ag/TiO2 films proved to be very stable and efficient for the simultaneous degradation of the studied hormones up to 305 h of reaction period, obtaining a percentage of degradation above 90%. © 2019 Society of Chemical Industry

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Reproductive effects in fathead minnows (Pimphales promelas) following a 21 d exposure to 17α-ethinylestradiol

Cited by 44 publications

References 35 publications

Removal of 17-α Ethinylestradiol from Water Systems by Adsorption on Polyacrylonitrile Beads: Isotherm and Kinetics Studies

Removal of 17-α Ethinylestradiol from Water Systems by Adsorption on Polyacrylonitrile Beads: Isotherm and Kinetics Studies

17α-ethynylestradiol prevents the natural male-to-female sex change in gilthead seabream (Sparus aurata L.)

Application of a stable Ag/TiO₂ film in the simultaneous photodegradation of hormones

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Reproductive effects in fathead minnows (Pimphales promelas) following a 21 d exposure to 17α-ethinylestradiol

Cited by 44 publications

References 35 publications

Removal of 17-α Ethinylestradiol from Water Systems by Adsorption on Polyacrylonitrile Beads: Isotherm and Kinetics Studies

Removal of 17-α Ethinylestradiol from Water Systems by Adsorption on Polyacrylonitrile Beads: Isotherm and Kinetics Studies

17α-ethynylestradiol prevents the natural male-to-female sex change in gilthead seabream (Sparus aurata L.)

Application of a stable Ag/TiO2 film in the simultaneous photodegradation of hormones

Contact Info

Product

Resources

About

Application of a stable Ag/TiO₂ film in the simultaneous photodegradation of hormones