Abstract:In this retrospective cohort study (n = 479), the proportion of women with premature ovarian insufficiency (POI) who conceived was assessed, the reproductive characteristics of women with POI who had previously been pregnant or had never been pregnant compared, and the interval between last conception and the menopause in women with POI who had become pregnant assessed. Time to pregnancy and maternal age at first childbirth were compared between women with POI and population-based controls (n = 2304). Women wi… Show more
“…Asymptomatic women of 45 years or older (maximum age 73 years) with a previous POI diagnosis were eligible for inclusion in the current study. POI was diagnosed before the age of 40 and a median period of 10.0 years (IQR (interquartile range): 8‐10 years) prior to the current study by a standardized endocrinological assessment along with a physical examination and a transvaginal ultrasound scan . POI was defined as the presence of amenorrhoea for at least 4 months and an increased FSH serum concentration measured on two occasions: one of which >40 IU/L, before the age of 40 years.…”
Section: Methodssupporting
confidence: 77%
“…POI was diagnosed before the age of 40 and a median period of 10.0 years (IQR (interquartile range): 8-10 years) prior to the current study by a standardized endocrinological assessment along with a physical examination and a transvaginal ultrasound scan. 21,22 POI was defined as the presence of amenorrhoea for at least 4 months and an increased FSH serum concentration measured on two occasions: one of which >40 IU/L, before the age of 40 years. A second cardiovascular screening at the time of the CAC measurement was offered to all eligible women.…”
Objective
Women with premature ovarian insufficiency (POI) enter menopause before age 40. Early menopause was associated with increased risk for coronary artery disease (CAD), death from cardiovascular disease and all‐cause mortality. We compared the prevalence of CAD between middle‐aged women on average 10 years following the initial POI diagnosis, with a population‐based cohort.
Design
Cross‐sectional case‐control study.
Participants
Women from two Dutch University Medical Centers above 45 years of age previously diagnosed with POI (n = 98) were selected and compared with age‐ and race‐matched controls from the Multi‐Ethnic Study of Atherosclerosis (MESA).
Measurements
The primary outcome was detectable coronary artery calcium (CAC) determined by coronary computed tomography (CCT).
Results
Women with POI had significantly higher blood pressure, cholesterol and glucose, despite lower BMI compared to controls. Similar proportions of detectable CAC (CAC score >0 Agatston Units) were observed in women with POI and controls (POI n = 16 (16%), controls n = 52 (18%), P = 0.40 and Padj = 0.93). In women with POI separately, we were not able to identify associations between CVD risk factors and CAC. The following CVD risk factors in controls were positively associated with CAC: age, diabetes mellitus, hypertension and LDL cholesterol. HRT use was negatively associated with CAC in controls.
Conclusions
The presence of CAC did not differ significantly in women with POI around 50 years of age, compared to an age‐ and race‐matched control group. We observe no increased calcified coronary disease in POI patients, despite the presence of unfavourable cardiovascular risk factors in these women.
“…Asymptomatic women of 45 years or older (maximum age 73 years) with a previous POI diagnosis were eligible for inclusion in the current study. POI was diagnosed before the age of 40 and a median period of 10.0 years (IQR (interquartile range): 8‐10 years) prior to the current study by a standardized endocrinological assessment along with a physical examination and a transvaginal ultrasound scan . POI was defined as the presence of amenorrhoea for at least 4 months and an increased FSH serum concentration measured on two occasions: one of which >40 IU/L, before the age of 40 years.…”
Section: Methodssupporting
confidence: 77%
“…POI was diagnosed before the age of 40 and a median period of 10.0 years (IQR (interquartile range): 8-10 years) prior to the current study by a standardized endocrinological assessment along with a physical examination and a transvaginal ultrasound scan. 21,22 POI was defined as the presence of amenorrhoea for at least 4 months and an increased FSH serum concentration measured on two occasions: one of which >40 IU/L, before the age of 40 years. A second cardiovascular screening at the time of the CAC measurement was offered to all eligible women.…”
Objective
Women with premature ovarian insufficiency (POI) enter menopause before age 40. Early menopause was associated with increased risk for coronary artery disease (CAD), death from cardiovascular disease and all‐cause mortality. We compared the prevalence of CAD between middle‐aged women on average 10 years following the initial POI diagnosis, with a population‐based cohort.
Design
Cross‐sectional case‐control study.
Participants
Women from two Dutch University Medical Centers above 45 years of age previously diagnosed with POI (n = 98) were selected and compared with age‐ and race‐matched controls from the Multi‐Ethnic Study of Atherosclerosis (MESA).
Measurements
The primary outcome was detectable coronary artery calcium (CAC) determined by coronary computed tomography (CCT).
Results
Women with POI had significantly higher blood pressure, cholesterol and glucose, despite lower BMI compared to controls. Similar proportions of detectable CAC (CAC score >0 Agatston Units) were observed in women with POI and controls (POI n = 16 (16%), controls n = 52 (18%), P = 0.40 and Padj = 0.93). In women with POI separately, we were not able to identify associations between CVD risk factors and CAC. The following CVD risk factors in controls were positively associated with CAC: age, diabetes mellitus, hypertension and LDL cholesterol. HRT use was negatively associated with CAC in controls.
Conclusions
The presence of CAC did not differ significantly in women with POI around 50 years of age, compared to an age‐ and race‐matched control group. We observe no increased calcified coronary disease in POI patients, despite the presence of unfavourable cardiovascular risk factors in these women.
“…In addition, women suffering a premature menopause have higher risk of problems such as anxiety, depression and other psychological symptoms compared to women with normal ovarian function [12,13,14]. …”
Menopause is a period of women’s life characterized by the cessation of menses in a definitive way. The mean age for menopause is approximately 51 years. Primary ovarian insufficiency (POI) refers to ovarian dysfunction defined as irregular menses and elevated gonadotrophin levels before or at the age of 40 years. The etiology of POI is unknown but several genes have been reported as being of significance. The fragile X mental retardation 1 gene (FMR1) is one of the most important genes associated with POI. The FMR1 gene contains a highly polymorphic CGG repeat in the 5′ untranslated region of exon 1. Four allelic forms have been defined with respect to CGG repeat length and instability during transmission. Normal (5–44 CGG) alleles are usually transmitted from parent to offspring in a stable manner. The full mutation form consists of over 200 repeats, which induces hypermethylation of the FMR1 gene promoter and the subsequent silencing of the gene, associated with Fragile X Syndrome (FXS). Finally, FMR1 intermediate (45–54 CGG) and premutation (55–200 CGG) alleles have been principally associated with two phenotypes, fragile X tremor ataxia syndrome (FXTAS) and fragile X primary ovarian insufficiency (FXPOI).
“…This observation suggests a high rate of ovarian follicle atresia prior to early menopause. Rapid ovarian follicle atresia prior to early menopause is also supported by a recent Dutch study of 111 women diagnosed with premature ovarian insufficiency (Daan et al, 2016).…”
This study showed that more than 50% of the women who reached menopause before the age of 45 years had had a successful pregnancy within 10 years prior to natural menopause. Among women with menopause in their mid-fifties, less than 1% had had a successful pregnancy within the 10 years before natural menopause.
ABSTRACTResearch question: Does a successful spontaneous pregnancy in the years close to natural menopause depend on age at menopause?Design: This was a retrospective population-based study of 4157 parous postmenopausal women in Norway, born during the years 1925-1940. Data were obtained by two self-administered questionnaires in the HUNT2 Survey (1995)(1996)(1997). We calculated the proportions of women who gave birth within 5 years and within 10 years prior to menopause both among all women, and according to categories of age at menopause.
Results:Overall, 2.7% (114/4157) of all women gave birth within 5 years, and 11.7% (487/4157) gave birth within 10 years, prior to menopause. Among women with menopause before the age of 45 years, 23.5% (81/344) gave birth within 5 years, and 55.5% (191/344) gave birth within 10 years, before menopause. Among the women with menopause at the age of 55 years or older, no women (0/474) gave birth within 5 years, and 0.2% (1/474) gave birth within 10 years, prior to menopause.
Conclusions:More than half of the women with menopause before the age of 45 years gave birth within the 10 years before natural menopause, whereas virtually no women with menopause at the age of 55 years or older did. Thus, the length of the sterile interval before natural menopause may vary by age at menopause.
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