Reproductive Biology

Hendrickx, Andrew G.

doi:10.1016/b978-012088661-6/50011-9

Cited by 34 publications

(21 citation statements)

References 300 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cynomolgus macaque has regular monthly menstrual cycles similar to that of humans (B28 days) (Weinbauer et al, 2008a). The duration of spermatogenesis is 40-46 days compared to 64-74 days in humans (Amann et al, 1976;Amann, 2008;Aslam et al, 1999;Hendrickx and Dukelow, 2005). Organogenesis is also similar in humans and macaques (approximately gestation day 20-50) (Makori et al, 1996).…”

Section: Introductionmentioning

confidence: 84%

Developmental and reproductive toxicology studies in nonhuman primates

Chellman¹,

Bussiere

Makori

et al. 2009

Birth Defects Research Pt B

133

View full text Add to dashboard Cite

Developmental and reproductive toxicology testing in nonhuman primates (NHPs) has become more common due to the increasing number of biopharmaceuticals in drug development, since NHPs are frequently the only species to express pharmacologic responses similar to humans. NHPs may also be used to help resolve issues associated with small-molecule reproductive toxicology in traditional species (rodents and rabbits). Adequate designs in NHP are presented for developmental toxicity (embryo-fetal development, pre-postnatal development, enhanced pre-postnatal development), reproductive toxicity (male and female), and juvenile toxicity studies. Optional parameters that may be included in these studies are discussed, as are new study designs that consolidate multiple aspects of the reproductive assessment and thereby conserve the limited supply of sexually mature NHPs available for testing. The details described will assist scientists in pharmaceutical, regulatory, and contract research organizations who are involved in conducting these unique studies to optimize their design based on case-by-case considerations.

show abstract

Section: Introductionmentioning

confidence: 84%

Developmental and reproductive toxicology studies in nonhuman primates

Chellman¹,

Bussiere

Makori

et al. 2009

Birth Defects Research Pt B

133

View full text Add to dashboard Cite

show abstract

“…A second pattern of early weaning was associated with high resource availability and good maternal condition. Comparisons of provisioned and non-provisioned populations have revealed that provisioned females exhibit shorter interbirth intervals and lactational periods, live longer, and exhibit higher infant survival rates than non-provisioned conspecifics (see reviews in Paul and Kuester, 1988;Asquith, 1989;Hendrickx and Dukelow, 1995). Additionally, there are reports that females with access to higher quality (but nonprovisioned) diets (e.g., vervet monkeys: Hauser and Fairbanks, 1988) and those with high dominance rank (e.g., yellow baboons, Papio hamadryas cynocephalus: Altmann and Samuels, 1992) invest less time and energy in offspring than females in relatively moderate condition and/or access to resources of moderate quality.…”

Section: Discussionmentioning

confidence: 99%

Opportunistic mothers: female marmosets (Callithrix kuhlii) reduce their investment in offspring when they have to, and when they can

Fite

Patera

French

et al. 2005

Journal of Human Evolution

View full text Add to dashboard Cite

All female primates incur energetic costs associated with producing and caring for offspring, but females belonging to the New World primate family Callitrichidae, the marmosets and tamarins, appear to face even further demands. In fact, the energetic demands of rearing callitrichid infants are thought to have led to the evolution of cooperative infant care in these species. If this explanation is true, then one might expect that natural selection should also have shaped patterns of maternal behavior to be sensitive to the costs of reproduction and equipped females to reduce their investment in offspring under certain conditions. Therefore, we examined the maternal effort and postpartum endocrine profiles of individual female marmosets (Callithrix kuhlii) across conditions that represented two hallmarks of callitrichid reproduction-conception during the early postpartum period and alloparental assistance. When females conceived during the early postpartum period and faced the upcoming demands of caring for their newly conceived litters (Study 1), they significantly reduced their caregiving effort and had significantly higher postpartum levels of estradiol relative to breeding attempts in which conception occurred later in the postpartum period. Postpartum estradiol was negatively correlated with maternal carrying effort. When experienced alloparents were present (Study 2), females again reduced their caregiving effort relative to breeding attempts in which experienced alloparents were not present. Postpartum cortisol, however, did not vary as a function of experienced alloparental assistance. The results of these studies suggest that female marmosets have been subjected to similar selection pressures as females of other primate taxa-to maximize their reproductive success by reducing their investment in offspring under the worst and best of conditions-and suggest that hormones may mediate within-female variation in maternal care. These studies also provide support for the notion that mothers are "flexible opportunists" when it comes to providing care to their young.

show abstract

“…Osteoarthritis affects an estimated 20.7 million Americans, 10 million people currently have osteoporosis in the United States, and another 18 million have low bone mass [1,2]. Osteoporosis affects 1 Data referenced were compiled from Mills et al [19], Bowden [14], Harvey et al [20], Hendrickx and Dukelow [21], Hakeem et al [22], and * personal communication: Jurke. of every 3 women and 1 of every 8 men and results in 1.5 million fractures a year [1]. Female menopause, the most visible sign of reproductive aging, is associated with increased risk of osteoporosis, cardiovascular disease and diabetes [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

Nonhuman Primate Models of Skeletal and Reproductive Aging

Black

Lane²

2002

Gerontology

View full text Add to dashboard Cite

Background: Bone loss, osteoarthritis (OA) and age-related changes in reproduction are some of the most apparent and troubling results of advancing age in the human population. The significance of these changes underscores the need for developing appropriate animal models to study aging of bone and the reproductive system. Objective: This review surveys the literature regarding the current state of nonhuman primates (NHP) as models for skeletal and reproductive aging in humans. Results: Several species of NHP exhibit age-related bone loss as well as changes in the mineral content and architecture of bone that are similar to those reported in humans. In addition, since aged females of some species of NHP exhibit cessation of menses and serum hormone profiles consistent with those described in peri- and premenopausal women, they provide useful models of postmenopausal bone loss. Sensitivity to surgical estrogen depletion and hormone replacement has also been demonstrated in female NHP. Spontaneous development of degenerative arthritis, analogous to humans in age at onset, joint involvement and histologic changes, suggest that NHP are suitable for the study of human OA. Many similarities exist between female NHPs and women in age-related changes in reproductive function including hormone concentrations, menstrual cycling, fertility and the development of endometriosis. Changes in male sexual behavior and fertility with age are also comparable in men and male NHP. Conclusions: Genetic similarity, long lives and similar reproductive endocrinology suggest that NHPs are likely candidates as models of skeletal and reproductive aging in humans. Current data confirm that several species of NHP exhibit changes in bone and reproduction that are comparable to those known to occur in humans.

show abstract

Reproductive Biology

Cited by 34 publications

References 300 publications

Developmental and reproductive toxicology studies in nonhuman primates

Developmental and reproductive toxicology studies in nonhuman primates

Opportunistic mothers: female marmosets (Callithrix kuhlii) reduce their investment in offspring when they have to, and when they can

Nonhuman Primate Models of Skeletal and Reproductive Aging

Contact Info

Product

Resources

About