Reproductive behaviors and risk of developing breast cancer according to tumor subtype: A systematic review and meta-analysis of epidemiological studies

Lambertini, Matteo; Santoro, Luigi; Mastro, Lucia Del; Nguyen, Bastien; Livraghi, Luca; Ugolini, Donatella; Peccatori, Fedro Alessandro; Azim, Hatem Hamdy Abdel

doi:10.1016/j.ctrv.2016.07.006

Cited by 188 publications

(182 citation statements)

References 45 publications

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“…Another limitation is that breast cancer has been shown to be an etiologically heterogeneous disease, with studies showing modification of known associations by tumor subtype. 58,59 However, to date, only two studies examined associations of biomarkers of oxidative stress with breast cancer risk by tumor ER status, 30,47 and no studies have evaluated associations by molecular subtypes. Finally, differences in how menopausal status was defined across studies, a known methodological limitation in epidemiological studies considering menopausal status, 60 or lack of stratifying results by menopausal status could have contributed to inconsistencies in findings.…”

Section: Biomarkers Of Oxidative Stress and Risk Of Developing Breastmentioning

confidence: 99%

The Role of Biomarkers of Oxidative Stress in Breast Cancer Risk and Prognosis: A Systematic Review of the Epidemiologic Literature

Lee¹,

Cai

Shu

et al. 2017

Journal of Women's Health

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Background: Oxidative stress may play an important role in both initiation and progression of breast cancer. We conducted the first systematic epidemiologic review to summarize the published literature on oxidative stress biomarkers and breast cancer. Materials and Methods: We implemented systematic search strategies to identify published studies of oxidative stress biomarkers and (1) risk of developing breast cancer and (2) breast cancer prognosis using the PRISMA statement guidelines. Results: We identified eleven case-control studies of oxidative stress biomarkers and breast cancer. Biomarkers utilized varied and menopausal status was a key modifying factor. Across three nested case-control studies with biomarkers measured before diagnosis, one reported increased risk of postmenopausal breast cancer in association with 8-oxodG (DNA damage biomarker), while two (one of F 2 -isoprostanes and one of fluorescent oxidation products) reported inverse associations for premenopausal breast cancer only. We identified eight prognostic studies. Two reported associations for lipid peroxidation and breast cancer prognosis; results for other studies were null. Conclusions: DNA damage may increase risk of breast cancer among postmenopausal women, while lipid peroxidation may be inversely associated with premenopausal breast cancer. Lipid peroxidation may be associated with survival after breast cancer diagnosis; however, results require evaluation in large, prospective cohort studies.

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Section: Biomarkers Of Oxidative Stress and Risk Of Developing Breastmentioning

confidence: 99%

The Role of Biomarkers of Oxidative Stress in Breast Cancer Risk and Prognosis: A Systematic Review of the Epidemiologic Literature

Lee¹,

Cai

Shu

et al. 2017

Journal of Women's Health

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show abstract

“…Due to lack of molecular targets and high heterogeneity, different from those of the HER2‐amplified breast cancers, TNBC could not benefit from the progression of recent targeted therapy. Furthermore, cytotoxic chemotherapy, only partially, reduced the recurrence and death risk, making TNBC a challenge requiring more effective targeted therapies 36, 37. Owing to these reasons, we focused our study on TNBC.…”

Section: Discussionmentioning

confidence: 99%

Friend leukemia virus integration 1 is a predictor of poor prognosis of breast cancer and promotes metastasis and cancer stem cell properties of breast cancer cells

et al. 2018

Cancer Medicine

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Breast cancer is the most common cancer in women worldwide; despite the developments in diagnosis and therapy, recurrence and metastasis remain the main causes of death among patients with breast cancer. This study aimed to identify a promising biomarker for this disease. The study clarified (1) the association between Friend leukemia virus integration 1 (FLI‐1) and various molecular subtypes and (2) the prognostic value of FLI‐1 in breast cancer. To the best of our knowledge, this study is the first to report that FLI‐1 is a predictor of poor prognosis in patients with breast cancer and overexpressed in the triple negative breast cancer (TNBC) subtype. To further verify the effect of FLI‐1 in promoting the metastasis of TNBC, we performed a series of functional experiments in vitro and orthotopic xenograft experiments in the mammary fat pad of nude mice. FLI‐1, as a transcription factor, bound to the promoters of key EMT‐related genes (CDH1 and VIM), and regulated their expressions at the transcriptional level, thus induced epithelial‐mesenchymal transition (EMT). The overexpression of FLI‐1 significantly upregulated the expression of mesenchymal markers. After the modulation of FLI‐1, the changes in mammary stem cell markers (ALDH1A1 and CD133) and the capacity to form mammospheres were consistent with those of the EMT‐related markers. The orthotopic xenograft models further confirmed that the attenuation of stem cell traits after silencing FLI‐1 decreased the ability of tumorigenesis. These results indicate that FLI‐1 is a useful predictor of poor prognosis in patients with breast cancer. Furthermore, the preliminary exploration of metastatic mechanism in the patients with TNBC will provide a potential target to treat breast cancer in the near future.

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“…Age ≥30 years at first full-term pregnancy, another accepted "risk factor" shows a marked decrease, near the half, in the most recent series although the percentages are low in both series compared with published data [41,42]. Considering the number of children born alive as a protective factor [43,44] we see that number of 2 children was and is the most common;this data is consistent with the average number of children obtained in population censuses near the years in which the studies were conducted. The decrease in group 1 child observed in the 2012-2013 series is offset by the increase in the group of 3 or more children seen in the same series.…”

Section: Risk and Protective Factorsmentioning

confidence: 98%

Breast Cancer Thirty Years Later: A Comparative Study between A 1983-1984 AND A 2012-2013 Cohorts of Argentine Women

Kress¹

2017

J Can Epi Treat

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Background: In Argentina the breast cancer is the most common cancer among women with an incidence rate (ARS) of 71, 2 x 100,000. Changes in the patterns of behavior of women in the last 30 years with the adoption or increase of certain behaviors considered as risk factors for breast cancer may influence on the clinical, surgical, pathological and epidemiological patterns of presentation of the breast cancer.

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Reproductive behaviors and risk of developing breast cancer according to tumor subtype: A systematic review and meta-analysis of epidemiological studies

Cited by 188 publications

References 45 publications

The Role of Biomarkers of Oxidative Stress in Breast Cancer Risk and Prognosis: A Systematic Review of the Epidemiologic Literature

The Role of Biomarkers of Oxidative Stress in Breast Cancer Risk and Prognosis: A Systematic Review of the Epidemiologic Literature

Friend leukemia virus integration 1 is a predictor of poor prognosis of breast cancer and promotes metastasis and cancer stem cell properties of breast cancer cells

Breast Cancer Thirty Years Later: A Comparative Study between A 1983-1984 AND A 2012-2013 Cohorts of Argentine Women

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