1987
DOI: 10.1093/bja/59.10.1291
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Reproductive and Teratogenic Effects of Nitrous Oxide, Fentanyl and Their Combination in Sprague-Dawley Rats

Abstract: The reproductive and teratogenic effects of 35% and 50% nitrous oxide, fentanyl 500 micrograms kg-1/day and their combinations were studied using a total of 419 timed-pregnant Sprague-Dawley rats. On day 7 of pregnancy, osmotic minipumps which delivered either fentanyl 500 micrograms kg-1/day or normal saline for 2 weeks were implanted subcutaneously in the back of the rats. Animals then were exposed to air, 35% nitrous oxide or 50% nitrous oxide for 24 h on day 9 of pregnancy. On day 21 of pregnancy, Caesarea… Show more

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Cited by 35 publications
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