Abstract:The quaking viable (qk v ) mutation, a spontaneous deletion of a multigenic region encompassing roughly 1 Mb at 5.9 cM on the proximal end of mouse chromosome 17, causes severe trembling in all homozygous animals and infertility in all homozygous males. Physiologically, quaking mice exhibit dysmyelination and postmeiotic spermatogenic arrest. Molecular defects in Qk v mice occur in the affected tissues, indicating the primary causes of these pathologies are cell autonomous. However, because both the reproducti… Show more
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