Reproductive and developmental toxicity studies of manufactured nanomaterials

Ema, Makoto; Kobayashi, Norihiro; Naya, Masato; Hanai, Sosuke; Nakanishi, Junko

doi:10.1016/j.reprotox.2010.06.002

Cited by 225 publications

(135 citation statements)

References 39 publications

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“…Several researchers have expressed concern about the possible adverse effects of nanoparticles on human health because of their ability to pass through biological membranes (132)(133)(134) and "translocate through the circulatory, lymphatic, and nervous systems to many tissues and organs" (132). Potential reproductive and developmental toxicity of manufactured nanomaterials was investigated in several experimental in vivo and in vitro studies reviewed by Ema et al (135). It was found that "high concentrations of TiO 2 nanoparticles affect the viability and proliferation of mouse Leydig cells, that gold nanoparticles reduced the motility of human sperm, that silver, aluminium, and molybdenum trioxide were toxic to mouse spermatogonia stem cells, that silica nanoparticles inhibited the differentiation of mouse embryonic stem cells and midbrain cells, respectively, and that cadmium selenium-core quantum dots inhibited pre-and postimplantation development of mouse embryos".…”

Section: Reproductive Effects Of Exposure To Metals As Nanoparticlesmentioning

confidence: 99%

Reproductive Toxicity of Metals in Men

Pizent¹,

Tariba²,

Živković³

2012

Archives of Industrial Hygiene and Toxicology

106

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A combination of genetic, environmental and lifestyle factors contributes to adverse effects on the reproductive health in men. Metals are pervasive in food, water, air, tobacco smoke, and alcoholic beverages. Experimental studies suggest that many metals have adverse effects on the male reproductive function. However, information about reproductive effects of human exposure to metals is scarce and/or inconsistent. This review summarises the information from epidemiological studies of the effects of metal exposure on reproductive function in men. Factors capable of affecting these relationships were identifi ed and discussed. A particular attention is given to the studies considering infl uence of concomitant exposure to various metals. These studies have generally confi rmed that even moderate-to low-level exposure to lead affects certain reproductive parameters, and that exposure to cadmium affects the prostate function and serum testosterone levels. Adverse effects of mercury, manganese, chromium and arsenic on semen quality and altered serum hormone are less well documented. There is no clear evidence that boron exposure may impair reproductive health in men. Only a few studies have investigated reproductive effects of concomitant exposure to several metals and controlled for potential confounders. Future studies should consider the contribution of combined exposure to various metals and/or other factors that may infl uence individual susceptibility to reproductive health impairment in men. KEY WORDS: human semen quality, metals, metalloids, metal interactions, sex hormonesPizent A, et al.

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Section: Reproductive Effects Of Exposure To Metals As Nanoparticlesmentioning

confidence: 99%

Reproductive Toxicity of Metals in Men

Pizent¹,

Tariba²,

Živković³

2012

Archives of Industrial Hygiene and Toxicology

106

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“…In fact, TNPs were shown to be transferred from pregnant mice to their pups [70][71][72][73]. When pregnant mice were treated with TNPs via subcutaneous injection, the genital and cranial nerve systems of the male offspring were affected [70].…”

Section: Developmental Toxicitymentioning

confidence: 99%

“…This finding can be explained by changes in the expression of genes associated with CNS development and function [72]. Maternal intranasal instillation with respirable TNPs increased allergic susceptibility [73] and caused pathologic and functional disorders and reduced daily sperm production in offspring [70].…”

Section: Developmental Toxicitymentioning

confidence: 99%

The potential health risk of titania nanoparticles

Zhang

Bai

Zhang

et al. 2012

Journal of Hazardous Materials

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“…After fusion of the gametes, a series of reprogramming events is activated, which includes DNA methylation, protamine exchange, histone marks, embryonic genome activation and degradation of maternal and paternal transcripts and proteins (Bermejo- Alvarez et al 2008, Kues et al 2008a. A well-orchestrated succession of these events is required to allow normal development, potentially making gametes and early embryos vulnerable to NPs, which may accumulate in the reproductive tract or which are intentionally added to spermatozoa in vitro (Bonde 2010, Ema et al 2010, Schrand et al 2010.…”

Section: Sperm Toxicity Of Aunpsmentioning

confidence: 99%

Sex selection of sperm in farm animals: status report and developmental prospects

Rath¹,

Barcikowski²,

Graaf³

et al. 2013

Reproduction

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Pre-selection of spermatozoa based on the relative DNA difference between X-and Y-chromosome bearing populations by flow cytometry is an established method that has been introduced into commercial cattle production. Although several important improvements have increased the sort efficiency, the fertilising ability of sexed spermatozoa based on offspring per insemination is still behind farmers' expectations. The main stress factors, especially on mitochondria, that reduce the lifespan of spermatozoa are described, and new technical as well as biological solutions to maintain the natural sperm integrity and to increase the sorting efficiency are discussed. Among these methods are the identification of Y-chromosome bearing spermatozoa by bi-functionalised gold nanoparticles and triplex hybridisation in vivo as well as new laser-controlled deflection system that replaces the deflection of spermatozoa in the electrostatic field. Additionally, as well as a new nonsurgical transfer system of spermatozoa into the oviduct of cows has been developed and allows a significant reduction of spermatozoa per transfer. Altogether, the improvements made in the recent years will allow a broader use of sex-sorted spermatozoa even in those species that require more cells than cows and sheep.Reproduction (2013) 145 R15-R30

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Reproductive and developmental toxicity studies of manufactured nanomaterials

Cited by 225 publications

References 39 publications

Reproductive Toxicity of Metals in Men

Reproductive Toxicity of Metals in Men

The potential health risk of titania nanoparticles

Sex selection of sperm in farm animals: status report and developmental prospects

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