Reproductive and developmental toxicity studies of toluene. I. Teratogenicity study of inhalation exposure in pregnant rats.

Ono, Atsushi; Sekita, Kiyoshi; Ohno, Keiko; Hirose, Akihiko; Ogawa, Yukio; Saito, Minoru; Naito, Katsushi; Kaneko, Toyozo; Furuya, Tsuyoshi; Matsumoto, Kiyoshi; Tanaka, Satoru; Kurokawa, Yuji

doi:10.2131/jts.20.109

Cited by 29 publications

(15 citation statements)

References 12 publications

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“…With these exposure patterns to males or females, there were no significant effects on fertility or reproductive performance, but fetal growth was significantly affected [Roberts et al 2003]. A similar pattern of exposure used by Ono et al [1996] also had no effect on fertility, but these studies do not model patterns of exposure typical of solvent abuse.…”

Section: Impact Of Toluene On Fertility and Reproductive Functionmentioning

confidence: 91%

Reproductive Toxicology and Teratology of Abused Toluene

Hannigan

Bowen

2010

Systems Biology in Reproductive Medicine

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Reproductive Toxicology and Teratology of Abused TolueneToluene is an organic solvent that is widely used by industry and is ubiquitous in our environment. As a result, exposure to solvents like toluene in workrelated settings (i.e., relatively constant, low-level exposures) or through inhalant abuse (i.e., relatively intermittent, high-level exposures) is increasing for many women of reproductive age. Evidence suggests that the risk for pregnancy problems, as well as developmental delays and neurobehavioral difficulties, is higher for the children of women who have been exposed to high concentrations of organic solvents during pregnancy than for those who have not. These risks appear to be higher in cases of abuse exposure to solvents such as toluene, particularly in comparison to the risk for teratogenic outcomes with occupational solvent exposure. Despite this, the reproductive toxicology and teratology following abuse of toluene and other inhalants remains under-investigated. This brief review describes the current state of our understanding of the reproductive and teratogenic risk of gestational toluene abuse. The data to date suggest that the high levels of toluene exposure typical with inhalant abuse are more detrimental to fetal development than typical occupational exposure, and preclinical paradigms can be beneficial for investigating the processes and risks of prenatal solvent exposure. While substantial research has been done on the reproductive effects of occupational exposures to organic solvents, more research is needed on the outcomes and mechanisms of exposures typical of inhalant abuse.

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Section: Impact Of Toluene On Fertility and Reproductive Functionmentioning

confidence: 91%

Reproductive Toxicology and Teratology of Abused Toluene

Hannigan

Bowen

2010

Systems Biology in Reproductive Medicine

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“…Subacute exposure of male rats to a high level (2000 ppm) of toluene vapor can elicit mild toxic changes in the kidneys, thymus, and reproductive organs of males. The results demonstrated that toxic effects on the fertility and reproduction were not only in females but also in males exposed to toluene vapor 10) . In male rats thinner, particularly the components ethyl acetate and xylene, was reported to interfere with the functions of the testes and accessory reproductive organ; but toluene has no effect on these functions 11) .…”

Section: Effect Of Benzene Toluene and Xylene On Fertilitymentioning

confidence: 93%

Effect of Benzene, Toluene, Xylene on the Semen Quality and the Function of Accessory Gonad of Exposed Workers.

et al. 2001

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The effects on semen and the function of accessory gonad of workers after short and long term exposure to benzene, toluene, and xylene were examined. The semen and blood of 24 married workers exposed to benzene, toluene, and xylene were collected. Routine sperm characteristic, acrosin activity, and Lactate dehydrogenase C4 (LDH-C4) relative activity were detected. The results showed that benzene, toluene, and xylene were found in the blood and semen of some ex-workers at workplaces where the air concentration of benzene, toluene, and xylene exceeded the maximum allowable concentration (MAC). No such solvents were detected in the blood and semen of workers of the control group. The sperm vitality and sperm motility decreased in the exposed workers. The mean acrosin activity, γ γ γ γ γ-GT activity and LDH-C4 relative activity in the exposed workers were lower, and fructose concentration was higher than those in the control. There were negative correlations between sperm vitality, sperm activity, acrosin activity, or LDH-C4 relative activity and working history. These results suggest that the mixture of these solvents could affect the sperm and the function of accessory gonad. This might be one reason of the abnormal pregnancy outcome among the wives of workers exposed to benzene, toluene, and xylene.

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“…The reproductive and developmental toxicity of toluene in animals and man is well characterized (Donald et al 1991;Ono et al 1996). Studies have shown that in rats toluene just like ethanol, has toxic effects on the brain development as well as disturbances in the cognitive functions (Hass et al 1999).…”

mentioning

confidence: 99%