Reproductive and Developmental Toxicity of Metals: Female Reproductive System

Mattison, Donald R.; Gates, Allen H.; Léonard, A.; Wide, Mariann; Hemminki, Karri; Peereboom-Stegeman, J.H.J. Copius

doi:10.1007/978-1-4615-9346-1_3

Cited by 12 publications

(3 citation statements)

References 130 publications

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“…Several studies on the reproductive toxicity of lead and methylmercury have been conducted [Gerber et al, 1980;Lee, 1983;Leonard et al, 1983a;Mattison et al, 1983;Wide, 1983;Odenbro, 1984]. Potential embryological and reproductive toxicity of organic mercury has caused great concern [Leonard et al, 1983b].…”

Section: Discussionmentioning

confidence: 99%

Effects of metallic mercury on the perimenstrual symptoms and menstrual outcomes of exposed workers

Yang¹,

Chen²,

Jiang³

2002

American J Industrial Med

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Section: Discussionmentioning

confidence: 99%

Effects of metallic mercury on the perimenstrual symptoms and menstrual outcomes of exposed workers

Yang¹,

Chen²,

Jiang³

2002

American J Industrial Med

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“…These effects may also be due to the accumulation of metal in the placenta as well as in the fetus or to hormonal disorders (Mattison et al 1983;Trivedi et al 1989) The present investigation also revealed severe alterations in various hematological and biochemical parameters after the beryllium exposure. A significant fall was observed in hemoglobin percentage.…”

Section: Discussionmentioning

confidence: 86%

Protective effect of Tiron (4,5-dihydroxybenzene-1,3-disulfonic acid disodium salt) against beryllium-induced maternal and fetal toxicity in rats

Sharma

Shah

Shukla

2002

Archives of Toxicology

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The efficacy of Tiron (4,5-dihydroxybenzene 1,3-disulfonic acid disodium salt) was examined in the treatment of beryllium-induced maternal and developmental toxicity in rats. Single administration of beryllium nitrate at a dose of 50 mg/kg (i.m.) on day 13 of gestation caused reductions in fetal and placental weights, the number of implantation sites and number of corpora lutea, as well as causing post-implantation loss, stunted growth, increase in the number of resorptions, and also a disturbed sex ratio. Maternal toxicity was demonstrated by reduction in body weight gain. Administration of beryllium also showed significant alteration in the hematological and biochemical indices of the mother as well as the fetus. Marked decreases were recorded in hemoglobin percentage, blood sugar levels, serum protein contents and serum alkaline phosphatase activity. By contrast, significant elevation was found in the activity of transaminases (aspartate aminotransferase and alanine aminotransferase). Tissue protein contents, glycogen contents, activities of alkaline phosphatase, adenosine triphosphatase and succinic dehydrogenase of kidney, lungs and uterus, and maternal and fetal liver all showed significantly decreased values after beryllium exposure, and remarkable elevation was observed in acid phosphatase, glucose-6-phosphatase and hepatic lipid peroxidation. These parameters were restored considerably with administration of 471 mg/kg i.m. Tiron from days 14 to 18 of gestation. Atomic absorption spectrophotometry also revealed a high concentration of beryllium in different organs of pregnant rats. Interestingly, a small amount of metal ion was also detected in the fetus and reduced accumulation of beryllium was noticed after Tiron treatment.

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“…Nickel salts caused damage to the testicular germinal epithelium, inhibited spermatogenesis and decreased testosterone production (Lee 1983;Laskey and Phelps 1991;Forgács et al 1998Forgács et al , 2001. In females, nickel compounds increase the frequency of fetal resorptions, as well as stillborn and abnormal fetuses in mice and rats Jonsen 1980, 1981;Sunderman et al 1978;Saillenfait, 1991;Mattison et al 1983). According to Forgács' previous studies NiSO 4 at 10 mg/kg subcutaneously disturbed, and at 40 mg/kg inhibited the ovarian cycle in SPRD rats .…”

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confidence: 91%

Effect of Nickel (Ni²⁺) on Primary Human Ovarian Granulosa Cells In Vitro

Révész

Forgács

Lázár

et al. 2004

Toxicology Mechanisms and Methods

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Human ovarian granulosa cells obtained from women undergoing in vitro fertilization were exposed to 15.6, 31.25, 62.5, 125, 250, 500, 1000 muM Ni(2+) for 48 h. To determine the site of action of Ni(2+), the granulosa cells were stimulated to produce progesterone (P) by using maximally stimulating amounts of human chorionic gonadotropin (0.1 IU/ml hCG) or dibutyryl cyclic adenosine monophosphate (1 mM db-cAMP). The luteinizing hormone (LH) analog hCG was chosen because resultant P production requires an intact membrane receptor and db-cAMP was used to test for post LH receptor defects caused by Ni(2+). Progesterone content of the culture medium was determined by radioimmunoassay (RIA), and viability of the cells was measured by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) reduction test. Concentration-dependent depression in both hGC and db-cAMP stimulated P production was seen at 15.625 muM or higher concentration of Ni(2+), which is not cytotoxic on human ovarian granulosa cells. The viability of cells was unaffected up to 31.25 muM and decreased significantly at 62.5 muM. Our results show a dose-related depression in stimulated P production of granulosa cells at a dose that does not induce significant cytotoxic action. These data indicate that the effect of Ni(2+) on P production is not due to cytotoxicity, and the cellular site(s) of inhibitory action appears to be subsequent to the membrane receptor and production of cAMP.

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Reproductive and Developmental Toxicity of Metals: Female Reproductive System

Cited by 12 publications

References 130 publications

Effects of metallic mercury on the perimenstrual symptoms and menstrual outcomes of exposed workers

Effects of metallic mercury on the perimenstrual symptoms and menstrual outcomes of exposed workers

Protective effect of Tiron (4,5-dihydroxybenzene-1,3-disulfonic acid disodium salt) against beryllium-induced maternal and fetal toxicity in rats

Effect of Nickel (Ni²⁺) on Primary Human Ovarian Granulosa Cells In Vitro

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Reproductive and Developmental Toxicity of Metals: Female Reproductive System

Cited by 12 publications

References 130 publications

Effects of metallic mercury on the perimenstrual symptoms and menstrual outcomes of exposed workers

Effects of metallic mercury on the perimenstrual symptoms and menstrual outcomes of exposed workers

Protective effect of Tiron (4,5-dihydroxybenzene-1,3-disulfonic acid disodium salt) against beryllium-induced maternal and fetal toxicity in rats

Effect of Nickel (Ni2+) on Primary Human Ovarian Granulosa Cells In Vitro

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Effect of Nickel (Ni²⁺) on Primary Human Ovarian Granulosa Cells In Vitro