Reproductive and developmental F1 toxicity following exposure of pubescent F0 male mice to bisphenol A alone and in a combination with X-rays irradiation

Dobrzyńska, Małgorzata M.; Gajowik, Aneta; Jankowska‐Steifer, Ewa; Radzikowska, Joanna; Tyrkiel, E

doi:10.1016/j.tox.2018.10.007

Cited by 16 publications

(14 citation statements)

References 72 publications

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“…The litters from F1 and F2 exposed to 50 µg/kg BW/day, however, presented ratios in which female offspring prevailed over the control group. The percentage of males born in F3 exposed to the highest BPA concentrations (of 50 and 100 µg/kg BW/day), was higher than that of the females in the litters from F3, coinciding with authors such as Dobrzy ńska et al [44], who observed that the proportion of sexes was altered, accompanied by a decrease in sperm quality in generation F1 of mice, whose fathers (not mothers) were exposed for eight weeks, prior to crossing, to 5 and 10 mg/kg BW/day of BPA. They noted a prevalence of males over females, with respect to the control that was more marked at the highest exposure dose.…”

Section: Sex Ratiosupporting

confidence: 86%

Analysis of Indirect Biomarkers of Effect after Exposure to Low Doses of Bisphenol A in a Study of Successive Generations of Mice

Bujalance-Reyes

Molina-López

Ayala-Soldado

et al. 2022

Animals

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Bisphenol A (BPA) is considered as being an emerging pollutant, to which both animal and human populations are continuously and inadvertently exposed. The identification of indirect biomarkers of effect could be a key factor in determining early adverse outcomes from exposure to low doses of BPA. Thus, this study on mice aims to evaluate and identify indirect biomarkers of effect through the analysis of their blood biochemistry, and of certain reproduction parameters after exposure to different BPA concentrations (0.5, 2, 4, 50, and 100 µg/kg BW/day) in drinking water over generations. Our results showed that there were no modifications in the reproductive parameters evaluated, like estrous cycle duration, litter size, or the percentage of the young alive at reaching the weaning stage, at the exposure levels evaluated. However, there were modifications in the biochemical parameters, e.g., alterations in the glucose levels, that increased significantly (p < 0.05) in the breeders at the higher exposure doses (50 and 100 µg/kg BW/day in F1; 50 µg/kg BW/day in F2 and 100 µg/kg BW/day in F3), that would suggest that the BPA could induce hyperglycemia and its complications in adult animals, probably due to some damage in the pancreas cells; albumin, that increased in the breeders exposed to the highest dose in F1 and F3, inferring possible hepatic alterations. Further, total proteins showed a diminution in their values in F1 and F2, except the group exposed to 100 µg/kg BW/day, whereas in F3 the values of this parameter increased with respect to the control group, this aspect likely being related to a possible hepatic and renal alteration. Based on these results, glucose, albumin, and total proteins could initially be considered as early indicators of indirect effect after prolonged exposure to low BPA doses over generations.

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Section: Sex Ratiosupporting

confidence: 86%

Analysis of Indirect Biomarkers of Effect after Exposure to Low Doses of Bisphenol A in a Study of Successive Generations of Mice

Bujalance-Reyes

Molina-López

Ayala-Soldado

et al. 2022

Animals

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“…To compare the impact of both bisphenols, BPA and BPS were given in the same doses. The method of bisphenol administration was typical for this kind of experiment and was based on previous studies 68 , 74 . In order to give correct doses of bisphenols, according to the body weight, the animals were weighed once a week.…”

Section: Methodsmentioning

confidence: 99%

Effects of the long-term influence of bisphenol A and bisphenol S on the population of nitrergic neurons in the enteric nervous system of the mouse stomach

Makowska

Całka

Gonkowski

2023

Sci Rep

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Bisphenol A (BPA) is an endocrine disruptor commonly used in the production of plastics. Due to its relatively well-known harmful effects on living organisms, BPA is often replaced by its various analogues. One of them is bisphenol S (BPS), widely used in the plastics industry. Until recently, BPS was considered completely safe, but currently, it is known that it is not safe for various internal organs. However, knowledge about the influence of BPS on the nervous system is scarce. Therefore, the aim of this study was to investigate the influence of two doses of BPA and BPS on the enteric nitrergic neurons in the CD1 strain mouse stomach using the double-immunofluorescence technique. The study found that both substances studied increased the number of nitrergic neurons, although changes under the impact of BPS were less visible than those induced by BPA. Therefore, the obtained results, for the first time, clearly indicate that BPS is not safe for the innervation of the gastrointestinal tract.

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“…Cadmium (Cd) is a toxic heavy metal and ubiquitous environmental endocrine disruptor (EDC). Common EDCs, such as bisphenol A (BPA) ( Chen et al, 2015 ; Mao et al, 2015 ; Dobrzyńska et al, 2018 ), Di-2-ethylhexyl phthalate (DEHP) ( Dobrzyńska et al, 2012 ), 2,3,7,8-tetrachlorodibenzop-dioxin (TCDD) ( Manikkam et al, 2012 ; Baker et al, 2014 ; Bruner-Tran et al, 2014 ; Sanabria et al, 2016 ), and atrazine (ATZ) ( Hao et al, 2016 ), not only have adverse effects on the reproductive system of male animals, but also can cause reproductive harm to the offspring, especially the decrease of sperm quality. However, the specific mechanism of how epigenetic changes induced by these EDCs mediate intergenerational or transgenerational inheritance needs further exploration.…”

Section: Discussionmentioning

confidence: 99%

Differential Expression Profiles and Potential Intergenerational Functions of tRNA-Derived Small RNAs in Mice After Cadmium Exposure

Zhou

Zhang

Wang

et al. 2022

Front. Cell Dev. Biol.

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Cadmium (Cd) is a toxic heavy metal and ubiquitous environmental endocrine disruptor. Previous studies on Cd-induced damage to male fertility mainly focus on the structure and function of testis, including cytoskeleton, blood-testis barrier, and steroidogenesis. Nevertheless, to date, no studies have investigated the effects of Cd exposure on sperm epigenetic inheritance and intergenerational inheritance. In our study, we systematically revealed the changes in sperm tRNA-derived small RNAs (tsRNA) profiles and found that 14 tsRNAs (9 up-regulated and 5 down-regulated) were significantly altered after Cd exposure. Bioinformatics of tsRNA-mRNA-pathway interactions revealed that the altered biological functions mainly were related to ion transmembrane transport, lipid metabolism and cell membrane system. In addition, we focused on two stages of early embryo development and selected two organs to study the impact of these changes on cell membrane system, especially mitochondrion and lysosome, two typical membrane-enclosed organelles. Surprisingly, we found that the content of mitochondrion was significantly decreased in 2-cell stage, whereas remarkably increased in the morula stage. The contents of mitochondrion and lysosome were increased in the testes of 6-day-old offspring and livers of adult offspring, whereas remarkably decreased in the testes of adult offspring. This provides a possible basis to further explore the effects of paternal Cd exposure on offspring health.

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Reproductive and developmental F1 toxicity following exposure of pubescent F0 male mice to bisphenol A alone and in a combination with X-rays irradiation

Cited by 16 publications

References 72 publications

Analysis of Indirect Biomarkers of Effect after Exposure to Low Doses of Bisphenol A in a Study of Successive Generations of Mice

Analysis of Indirect Biomarkers of Effect after Exposure to Low Doses of Bisphenol A in a Study of Successive Generations of Mice

Effects of the long-term influence of bisphenol A and bisphenol S on the population of nitrergic neurons in the enteric nervous system of the mouse stomach

Differential Expression Profiles and Potential Intergenerational Functions of tRNA-Derived Small RNAs in Mice After Cadmium Exposure

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