Reproduction studies with 1α,25-dihydroxyvitamin D3 (calcitriol) in rats and rabbits

McClain, R.M.; Langhoff, Lasse; Hoar, Richard M.

doi:10.1016/0041-008x(80)90251-3

Cited by 12 publications

(7 citation statements)

References 16 publications

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“…This contrasts with experiments in rabbits which exhibited signs of maternal and fetal toxicity with the same dose (29). In humans, there is only one report of a pregnant woman suffering from vitamin D-resistant rickets who received very high doses of calcitriol (17-36 mg/day).…”

Section: Journal Of Endocrinology (1998) 139mentioning

confidence: 44%

Management of hypoparathyroidism during pregnancy--report of twelve cases

Callies

Arlt

Scholz

et al. 1998

European Journal of Endocrinology

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There is no established therapeutic regimen for treatment of hypoparathyroidism during pregnancy. This is due particularly to uncertainty about the use of vitamin D or its analogues, as in animal experiments teratogenic side-effects have been reported. Nevertheless, vitamin D or its analogues are required to control tetany predisposing to abortion and preterm labour. We herein report the course of two pregnancies in a hypoparathyroid woman treated with calcitriol (1,25(OH) 2 D 3 ). Additionally, we describe the outcome of pregnancy in ten women receiving calcitriol, reported to the Drug Safety Department (DSD), Hoffmann-La Roche AG.A 29-year-old hypoparathyroid woman receiving chronic treatment with calcitriol (0.25 mg/day) and calcium (1.5 g/day) was referred in the 6th week of her first pregnancy. Calcitriol was initially discontinued, but during the 20th week of pregnancy recurrent tetany occurred (serum calcium 1.74 mmol/l). Calcitriol (0.25 mg/day) was added, stabilizing serum calcium around 2.15 mmol/l with 1,25(OH) 2 D 3 concentrations around 60 ng/l (normal range 35-80 ng/l). To maintain normocalcaemia the calcitriol dose was increased to 0.5 mg/day during the 33rd week and to 0.75 mg/day shortly before delivery of a healthy girl in the 37th week. During her second pregnancy calcitriol was given initially at a dose of 0.25 mg/day with further adaptation to 0.5 mg/day during the 20th and to 1.00 mg/day in the 31st week. Serum calcium and 1,25(OH) 2 D 3 were continually within the lower normal range. She gave birth to another healthy girl during the 39th week. In eight of the ten pregnancies reported to the DSD no adverse effects of calcitriol (0.25-3.25 mg/day) were seen and healthy babies were delivered.In two retrospectively reported cases, serious adverse events were described: premature closure of the frontal fontanelle, and stillbirth in the 20th week due to complex fetal malformation respectively. However, in both cases the causative role of calcitriol administration remains highly questionable.We conclude that, during pregnancy, management of maternal hypoparathyroidism with calcitriol and calcium is feasible, if the 1,25(OH) 2 D 3 concentrations are adapted to the physiological needs during pregnancy and serum calcium levels are kept in the lower normal range.

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Section: Journal Of Endocrinology (1998) 139mentioning

confidence: 44%

Management of hypoparathyroidism during pregnancy--report of twelve cases

Callies

Arlt

Scholz

et al. 1998

European Journal of Endocrinology

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“…The cause for an increased number of mummified piglets with additional vitamin D in the feeding ratio remains unclear. However, it is known that an overdose of vitamin D is fetotoxic in mammals [ 9 ], and can lead to abortion at different stages of pregnancy in sows [ 10 ]. Furthermore, the litter size is positively associated with the number of stillborn piglets type I [ 18 , 22 , 25 ] due to limitation of the uterine space.…”

Section: Discussionmentioning

confidence: 99%

“…In pigs, it is described that vitamin D has an effect on fertility during gestation [ 8 ]. On the other hand, it is known that an overdose of vitamin D is fetotoxic in mammals [ 9 ], and can lead to abortion at different stages of pregnancy in sows [ 10 ]. Overall, it is evident that vitamin D influences the reproductive tract and reproductive performance in mammals [ 1 , 2 , 3 , 8 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of 1,25-Dihydroxyvitamin D3-Glycosides on the Farrowing Process and Piglet Vitality in a Free Farrowing System

Jahn

Schüpbach‐Regula

Grahofer

2022

Animals

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Vitamin D improves the reproductive efficiency in animals. This study aimed to examine the effects of 1,25-dihydroxyvitamin D3-gylcosides (1,25 vitD) on the farrowing process in sows and the vitality of their piglets. In total, 100 sows were allocated into two groups at insemination (‘1,25 vitD’ and ‘negative control’). The 1,25-vitD group received 260–300 mg/sow/day 1,25-vitD in their feed during the gestation period. Backfat thickness, fecal score, and the farrowing process was evaluated. The piglets were categorized into live born or stillborn, and vitality was evaluated by assessing the umbilical cord and the meconium score. The number of total-born piglets in sows of ‘1,25 vitD’ was higher and the farrowing duration was shorter than in the negative control group without showing significance in the univariable analysis. In a linear multiple regression model including the variables ‘farrowing duration’, ‘total born piglets’ and ‘1,25 vitD’ differences became evident. We found that 1,25-vitD was associated with a reduced farrowing duration (p = 0.055). Moreover, significantly more mummies (p < 0.01) and short ruptured umbilical cords (p < 0.05) were observed in the 1,25-vitD group. This study showed an effect of 1,25-vitD on the farrowing process. However, more research is needed to better describe the mechanism of 1,25-vitD in detail.

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“…This metabolite is then transferred to the kidney and converted to 24-, 25-, or 1,25-dihydrocholecalciferol by mitochondrial mixed-function oxidases (McClain et al, 1980). After their intestinal absorption, ergocalciferol (vitamin D 2 ) and cholecalciferol (vitamin D 3 ) undergo an identical metabolic C pathway (Fournier et al, 1985).…”

Section: (A) Absorption Distribution and Excretionmentioning

confidence: 99%

“…Calcitriol induced maternal mortality and fetotoxicity in rabbits treated with 0.3 g/kg/day. Two litters at the highest dose and one litter at the middle-dose level contained fetuses with multiple abnormalities (McClain et al, 1980).…”

Section: (C) Effects On Reproductionmentioning

confidence: 99%

Rodenticides

Pelfrène¹

2010

Hayes' Handbook of Pesticide Toxicology

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Reproduction studies with 1α,25-dihydroxyvitamin D3 (calcitriol) in rats and rabbits

Cited by 12 publications

References 16 publications

Management of hypoparathyroidism during pregnancy--report of twelve cases

Management of hypoparathyroidism during pregnancy--report of twelve cases

Effect of 1,25-Dihydroxyvitamin D3-Glycosides on the Farrowing Process and Piglet Vitality in a Free Farrowing System

Rodenticides

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