Reproduction of optical reflection‐intensity‐distribution using multimode laser coherence

This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. Optical coherence tomography has become a standard of care in ophthalmology, providing real-time information on structure and function – diagnosing disease, evaluating progression, and assessing response to therapy, as well as helping to understand disease pathogenesis and create new therapies. Optical coherence tomography also has applications in multiple clinical specialties, fundamental research, and manufacturing. We review the early history of OCT describing how research and development evolves and the important role of multidisciplinary collaboration and expertise. Optical coherence tomography had its origin in femtosecond optics, but used optical communications technologies and required advanced engineering for early OCT prototypes, clinical feasibility studies, entrepreneurship, and corporate development in order to achieve clinical acceptance and clinical impact. Critical advances were made by early career researchers, clinician scientists, engineering experts, and business leaders, which enabled OCT to have a worldwide impact on health care. We introduce the concept of an “ecosystem” consisting of research, government funding, collaboration and competition, clinical studies, innovation, entrepreneurship and industry, and impact – all of which must work synergistically. The process that we recount is long and challenging, but it is our hope that it might inspire early career professionals in science, engineering, and medicine, and that the clinical and research community will find this review of interest.

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“…11 Later studies by other groups demonstrated many applications of low-coherence interferometry in biological tissues. 12 – 15 …”

Section: From Femtosecond Optics To Biomedical Optics – the Origin Ofmentioning

confidence: 99%

The Development, Commercialization, and Impact of Optical Coherence Tomography

Fujimoto

Swanson

2016

Invest. Ophthalmol. Vis. Sci.

372

245

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“…This technique performs correlation or interference between light backscattered by the tissue and light that has travelled though a reference arm. Hitherto, different versions of low-coherence interferometry have been developed for non-invasive measurement in biological tissues [4][5][6][7]. Figure 1 shows a schematic diagram of a simple Michelson interferometer in time domain.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

Real Time Signal Processing and Data Handling with dedicated hardware in handheld OCT Device

Guerra

Valverde

Martin³

et al. 2015

J. Inst.

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AB STRACT: The manuscript presents the topics on real time signal processing with dedicated hardware presented at the INFIERI Summer School 2014. The focus of this work is on real-time signal processing, filtering and massive parallel computing. In general, medical devices have stringed demands on energy consumption as well as on data processing and handling. In fact, the development of novel medical devices has led to significant advances in fields such as instrumentation, algorithm development and image processing.In this manuscript, two aspects of the design are brought into consideration: the transformation of a conventional signal processing algorithm into an equivalent version that is suitable for hardware implementation and the use of on-chip modules originally developed for mass-electronics applications, for high speed data transmission. The development of a novel state-of-the-art handheld OCT probe is used to exemplify theses aspects. In particular, the "design process" behind the implementation of a multichannel quadrature coherent demodulator is disclosed.

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The Development of OCT

Fujimoto

Schmitt

Swanson

et al. 2014

Cardiovascular OCT Imaging

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Optical coherence tomography (OCT) enables cross sectional and volumetric imaging of internal structure and pathology in biological tissues. OCT can perform an "optical biopsy", imaging pathology in situ and in real time without the need for excisional biopsy. OCT imaging has become a standard of care in ophthalmology and is an emerging imaging modality in cardiology, where it provides information that often cannot be obtained by any other means. This chapter reviews the early history of OCT development with an emphasis on basic concepts and the process of technology translation. Early OCT technology and catheter imaging devices as well as advances in imaging speed using swept source/Fourier domain detection are reviewed. The process of clinical translation, beginning with ex vivo imaging and histology, preclinical animal studies and progressing to clinical studies in patients is discussed. The history of commercial intravascular OCT development is also summarized. Keywords

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Reproduction of optical reflection‐intensity‐distribution using multimode laser coherence

Cited by 4 publications

References 8 publications

The Development, Commercialization, and Impact of Optical Coherence Tomography

The Development, Commercialization, and Impact of Optical Coherence Tomography

Real Time Signal Processing and Data Handling with dedicated hardware in handheld OCT Device

The Development of OCT

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