Reproduction and development in are dependent upon catecholamines

Pendleton, Robert G.; Robinson, Nancy; Roychowdhury, Rupanjali; Rasheed, Aseel; Hillman, Ralph

doi:10.1016/s0024-3205(96)00562-0

Cited by 37 publications

(40 citation statements)

References 15 publications

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“…dVMAT mutants show an eggretention phenotype similar to mutants with reduced octopamineric signaling. However, they also show reduced ovary size supporting previous pharmacologic data that suggest a role for dopamine and/or serotonin in ovarian development (Monastirioti et al 1996;Neckameyer 1996;Pendleton et al 1996;Willard et al 2006).…”

Section: Discussionsupporting

confidence: 82%

“…In addition, unlike mutants that reduce octopaminergic signaling (Monastirioti 1999;Lee et al 2003;Cole et al 2005), they show an additional defect in oocyte development that is most easily observed in virgin females. This difference is consistent with previous pharmacologic data suggesting that dopaminergic and possibly serotonergic inputs regulate oocyte development (Neckameyer 1996;Pendleton et al 1996;Willard et al 2006) (see discussion).…”

Section: P1supporting

confidence: 92%

“…Remarkably, we find that homozygous mutants with little or no neuronal amine release not only survive, but show near normal or elevated responses to some environmental stimuli. This phenotype is in striking contrast to the enervating, and in some cases lethal effects of acute DVMAT inhibition with reserpine (Pendleton et al 1996(Pendleton et al , 2000Chang et al 2006), suggesting that the survival and behavior of the dVMAT mutants is the result of multiple adaptive changes in the nervous system.…”

Section: Discussionmentioning

confidence: 87%

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Drosophila Vesicular Monoamine Transporter Mutants Can Adapt to Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin

et al. 2009

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Physiologic and pathogenic changes in amine release induce dramatic behavioral changes, but the underlying cellular mechanisms remain unclear. To investigate these adaptive processes, we have characterized mutations in the Drosophila vesicular monoamine transporter (dVMAT), which is required for the vesicular storage of dopamine, serotonin, and octopamine. dVMAT mutant larvae show reduced locomotion and decreased electrical activity in motoneurons innervating the neuromuscular junction (NMJ) implicating central amines in the regulation of these activities. A parallel increase in evoked glutamate release by the motoneuron is consistent with a homeostatic adaptation at the NMJ. Despite the importance of aminergic signaling for regulating locomotion and other behaviors, adult dVMAT homozygous null mutants survive under conditions of low population density, thus allowing a phenotypic characterization of adult behavior. Homozygous mutant females are sterile and show defects in both egg retention and development; males also show reduced fertility. Homozygotes show an increased attraction to light but are mildly impaired in geotaxis and escape behaviors. In contrast, heterozygous mutants show an exaggerated escape response. Both hetero-and homozygous mutants demonstrate an altered behavioral response to cocaine. dVMAT mutants define potentially adaptive responses to reduced or eliminated aminergic signaling and will be useful to identify the underlying molecular mechanisms.A MINERGIC signaling pathways regulate a variety of complex behaviors in both the fly and mammals. In Drosophila melanogaster, dopamine is thought to regulate arousal (van Swinderen et al.

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Section: Discussionsupporting

confidence: 82%

Section: P1supporting

confidence: 92%

Section: Discussionmentioning

confidence: 87%

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Drosophila Vesicular Monoamine Transporter Mutants Can Adapt to Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin

et al. 2009

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“…This result also suggests that the vesicular release of DA and 5-HT may be dispensable for larval development and adult survival under standard culture conditions, an observation that is surprising given the fundamental role of DA in many physiological processes and the lethal effects of genetic (pale) (Kobayashi et al 1995) or pharmacologic inhibition of tyrosine hydroxylase activity (Neckameyer 1996;Pendleton et al 1996). Similarly, it has been proposed that 5-HT has a critical role in fly development (Colas et al 1999;Sykes and Condron 2005;Willard et al 2006;Schaerlinger et al 2007).…”

Section: Discussionmentioning

confidence: 95%

Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin inDrosophila melanogaster

Chen

Lebestky

et al. 2013

Genetics

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To investigate the regulation of Drosophila melanogaster behavior by biogenic amines, we have exploited the broad requirement of the vesicular monoamine transporter (VMAT) for the vesicular storage and exocytotic release of all monoamine neurotransmitters. We used the Drosophila VMAT (dVMAT) null mutant to globally ablate exocytotic amine release and then restored DVMAT activity in either individual or multiple aminergic systems, using transgenic rescue techniques. We find that larval survival, larval locomotion, and female fertility rely predominantly on octopaminergic circuits with little apparent input from the vesicular release of serotonin or dopamine. In contrast, male courtship and fertility can be rescued by expressing DVMAT in octopaminergic or dopaminergic neurons, suggesting potentially redundant circuits. Rescue of major aspects of adult locomotion and startle behavior required octopamine, but a complementary role was observed for serotonin. Interestingly, adult circadian behavior could not be rescued by expression of DVMAT in a single subtype of aminergic neurons, but required at least two systems, suggesting the possibility of unexpected cooperative interactions. Further experiments using this model will help determine how multiple aminergic systems may contribute to the regulation of other behaviors. Our data also highlight potential differences between behaviors regulated by standard exocytotic release and those regulated by other mechanisms. BOTH invertebrate and mammalian behaviors undergo extensive regulation by monoamine neurotransmitters (reviewed in Joshua et al.

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“…The tyrosine hydroxylase (TH) gene is the rate-limiting step in the dopamine biosynthesis pathway and is responsible for the hydroxylation of tyrosine into 3,4-dihydroxy-L-phenylalanine, which is then converted into dopamine by dopa decarboxylase (49). Pharmacological inhibition of TH, catecholamine uptake, and α-adrenoreceptor antagonists at 1 mM concentration results in failure of viable progeny whereas lower concentration (0.1 mM) significantly delayed the development, indicating the essential function of catecholamines in Drosophila development and viability (50). Drosophila tyrosine hydroxylase is encoded by the pale locus (51), and mutations in the pale gene result in decreased dopamine pools in adult heads, even in the heterozygous state (22).…”

Section: Discussionmentioning

confidence: 99%

Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration

Inamdar

Hossain

Bernstein

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Parkinson disease (PD) is the most common movement disorder and, although the exact causes are unknown, recent epidemiological and experimental studies indicate that several environmental agents may be significant risk factors. To date, these suspected environmental risk factors have been man-made chemicals. In this report, we demonstrate via genetic, biochemical, and immunological studies that the common volatile fungal semiochemical 1-octen-3-ol reduces dopamine levels and causes dopamine neuron degeneration in Drosophila melanogaster. Overexpression of the vesicular monoamine transporter (VMAT) rescued the dopamine toxicity and neurodegeneration, whereas mutations decreasing VMAT and tyrosine hydroxylase exacerbated toxicity. Furthermore, 1-octen-3-ol also inhibited uptake of dopamine in human cell lines expressing the human plasma membrane dopamine transporter (DAT) and human VMAT ortholog, VMAT2. These data demonstrate that 1-octen-3-ol exerts toxicity via disruption of dopamine homeostasis and may represent a naturally occurring environmental agent involved in parkinsonism.building-related illness | mold | mushroom alcohol

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Reproduction and development in are dependent upon catecholamines

Cited by 37 publications

References 15 publications

Drosophila Vesicular Monoamine Transporter Mutants Can Adapt to Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin

Drosophila Vesicular Monoamine Transporter Mutants Can Adapt to Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin

Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin inDrosophila melanogaster

Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration

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